Pharmacological Effects of Elenoside, an Arylnaphthalene Lignan.

Navarro, Eduardo; Alonso, S.J.; Alonso, Pedro Juan; Trujillo, Juan Manuel; Jorge, Elena Goicoechea de; Pérez, Cirilo

doi:10.1248/bpb.24.254

Cited by 19 publications

(15 citation statements)

References 39 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No lethality was observed for five days following administration of this compound (Alonso et al, 1997). As a consequence, this compound behaves as a sedative with broad-spectrum cytotoxicity (Navarro et al, 2001b), also showing cytotoxic effects toward leukemia cell lines (Navarro et al, 2001a).…”

Section: Biological Activity Of Compounds Isolated From Species Of Jumentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

115

View full text Add to dashboard Cite

Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

show abstract

Section: Biological Activity Of Compounds Isolated From Species Of Jumentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

115

View full text Add to dashboard Cite

show abstract

“…This lignan has a central depressant effect in animals [8][9][10] and cytotoxic activity when studied in a human tumor cell line panel of the US National Cancer Institute (NCI).…”

Section: /Kmentioning

confidence: 99%

“…This lignan has a central depressant effect in animals [8][9][10] and cytotoxic activity when studied in a human tumor cell line panel of the US National Cancer Institute (NCI). 9,10) Cytotoxic compounds produced alterations in the intestinal tract. In this work the effect of elenoside on isolated rat ileum is studied.…”

mentioning

confidence: 99%

Elenoside, a New Cytotoxic Drug, with Cardiac and Extracardiac Activity.

Navarro

Alonso

Trujillo

et al. 2002

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

A great number of arylnaphthalene lignans have been isolated from different species of Justicia, many of them exhibiting diverse biological activities, of which the most noteworthy are their antitumoral, antiviral, insecticidal, anti-inflammatory and anti-hypertensive properties.1) Also, the lignans on the central nervous system (CNS) are capable of acting both as depressants and antidepressants.2) On the other hand, some lignans are shown to be present in human and certain animal urine or semen and blood plasma.3,4) These mammalian lignans show an inhibitory effect on Ca 2ϩ channels, or digitalis-like action. Thus, 2,3 dibenzilbutane-1,4-diol is noted to inhibit K ϩ depolarization-induced and receptor-mediated contractions, so as to block Ca 2ϩ entry into the smooth muscle of rabbit aorta, and it blocks the insensitive Ca 2ϩ channels to organic Ca 2ϩ blockers, as well as the sensitive channels in rabbit femoral artery. Also, some lignans (enterolactone, prestegane B and 3-O- /Kϩ ATPase activity in red cells and produce inotropic and chronotropic effects, similar to cardiac glycosides. In the present paper, its effects on the isolated cardiac auricle of rabbits and the urinary excretion of rats (an other effect of cardiac glycosides) are studied.In a previous paper 7) we reported the isolation from Justicia hyssopifolia L. of an arylnaphathalene lignan and its aglycone, now called elenoside and elenin, respectively, the first as a b-D-glucoside. This lignan has a central depressant effect in animals [8][9][10] and cytotoxic activity when studied in a human tumor cell line panel of the US National Cancer Institute (NCI).9,10) Cytotoxic compounds produced alterations in the intestinal tract. In this work the effect of elenoside on isolated rat ileum is studied. MATERIAL AND METHODSReagents Elenoside: Phytochemical study of elenoside was realized. Air-dried and ground leaves were extracted in a Soxhlet with EtOH, with heating and under reflux, to afford an extract that was concentrated under reduced pressure. Column chromatography using solvents of increasing polarity (n-hexane, EtOAc, EtOH) gave different groups of fractions. Elenoside was recovered as needles from the most polar fractions of the ethanolic extract and identified by NMR and MS methods and by comparison with reported data. This lignan was determined to have the molecular formula: C 25 H 22 O 11 , with a molecular weight of MWϭ498.7) The elenoside was suspended in a mixture of propylene glycol-ethanol-plant oil-Tween 80 (40 : 10 : 50 : 2).Ouabain: Ouabain octahydrate (Janssen Chimica, Belgium) had the molecular formula C 29 H 44 O 12 · 8H 2 O and a molecular weight of MWϭ728.79.Animals Male albino rabbits (1000-1300 g) and male Sprague-Dawley rats (Letica, Barcelona, Spain; 250-300 g) were used. The animals were housed under normal laboratory conditions at 22°C on a standard light-dark schedule (12 : 12; lights on: 0800 to 2000) and were given free access to standard laboratory diet and water. The animals were assigned to randomized groups of 10 eac...

show abstract

“…Elenoside (NSC 644013-W/1) displayed cytotoxic activity when studied by the human tumour cell line panel of the US National Cancer Institute (NCI) [10]. Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs and could be an alternative to cisapride in the treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain [11].…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Neuropharmacological Effects of Elenine

Navarro

Alonso

Navarro

2011

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived from Justicia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

show abstract

Pharmacological Effects of Elenoside, an Arylnaphthalene Lignan.

Cited by 19 publications

References 39 publications

Chemical constituents and biological activities of species of Justicia: a review

Chemical constituents and biological activities of species of Justicia: a review

Elenoside, a New Cytotoxic Drug, with Cardiac and Extracardiac Activity.

Toxicity and Neuropharmacological Effects of Elenine

Contact Info

Product

Resources

About