Pharmacological Benefits of Triphala: A Perspective for Allergic Rhinitis

Abstract

Allergic rhinitis (AR) is considered a major nasal condition impacting a large number of people around the world, and it is now becoming a global health problem. Because the underlying mechanisms of AR are complex, the development of single-drug treatment might not be enough to treat a wide spectrum of the disease. Although the standard guidelines classify and provide suitable diagnosis and treatment, the vast majority of people with AR are still without any means of controlling it. Moreover, the benefits of AR drugs are sometimes accompanied by undesirable side effects. Thus, it is becoming a significant challenge to find effective therapies with limited undesirable side effects for a majority of patients suffering from uncontrolled AR. Aller-7/NR-A2, a polyherbal formulation, has revealed promising results in patients by reducing nasal symptoms and eosinophil counts without serious adverse effects. Interestingly, three out of seven of the herbals in the Aller-7/NR-A2 formulation are also found in an Ayurvedic polyherbal formulation known as “Triphala,” which is a potential candidate for the treatment of AR. However, there are no current studies that have examined the effects of Triphala on the disease. This review aims to describe the complexity of AR pathophysiology, currently available treatments, and the effects of Triphala on AR in order to help develop it as a promising alternative treatment in the future.

Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through computational investigations

“…Triphala (Ayurvedic herbal formulation) is made up of dried fruits from three different herbal plants in equal parts ( Jantrapirom et al, 2021 , Tarasiuk et al, 2018 ). Following a thorough review of the literature on the three plants T. chebula , T. bellirica , and P. emblica , 19 bioactive molecules were chosen for molecular docking against the M pro of SARS-CoV-2.…”

Antioxidant rich medicinal plants as a potential candidate to treat gastric ulcer

“…Triphala ash is applied in powder form on syphilitic ulcers to remove the ulcer exudates. Fine powder is mixed with dry T. chebula catechu and myrobalans, and then rubbed into a thick paste with blending oil or ghee to make ointment for wounds with chronic wounds and ulcers (Jantrapirom et al, 2021). T. chebula methanolic solution was given orally to patients with gastric ulcers at dose rates of 250 and 500 mg per kilogramme body weight, and it cured and reduced the ulcer's symptoms (Raju et al, 2009).…”

Insights into the potential benefits of triphala polyphenols toward the promotion of resilience against stress-induced depression and cognitive impairment

“…Among the many phytochemicals found in triphala are phenolic acids, ascorbic acid, flavonoids, alkaloids, and carbohydrates ( Jantrapirom et al, 2021 ). In general, polyphenols are the main components of triphala.…”