Pharmacological basis for the use of Fumaria indica in constipation and diarrhea

Pharmacological basis for the medicinal use ofHolarrhena antidysentericain gut motility disorders

“…Ca ++ antagonists have been shown to be beneficial in gut disorders resulting from hyperactivity such as abdominal cramps and diarrhea (Pasricha, 2006), hence the observed CCB effect justifies the medicinal use of Holarrhena antidysenterica in such conditions. Interestingly, such combinations of gut stimulatory and relaxant activities have been found commonly in plants used for two contrasting states of gut, i.e., constipation and diarrhea (Ghayur & Gilani, 2005b;Gilani et al, 2005a).…”

A review on ethnobotany, phytochemistry and pharmacology of Fumaria indica (Fumitory)

“…In vitro, the crude extract of F. indica and its fractions showed spasmogenic and spasmolytic effects due to the presence of cholinergic and calcium channel blockade constituents, which may explain the respective traditional use of the F. indica in constipation and diarrhea [30] .…”

Pharmacological evaluation and validation for the folkloric use of <i>Oligochaeta ramose</i> in constipation and diarrhea

“…It has been previously observed that spasmogenic (contractile) effect of the plants is usually mediated through cholinergic mechanism (acetylcholine like) (Gilani et al, 2000;Gilani et al, 2005), so for the conformation of this mechanism, spontaneous contracting isolated jejunum preparations were pretreated with 0.1 µM of atropine (anti-muscarinic agent) and waited for 25 min (tissue equilibration) before the administration of the plant extract (Arunlakhshana and Schild, 1959). Spasmogenic effect of the crude extract was completely abolished in atropinized tissue (Figure 1), while stimulatory effect of histamine remained unchanged, suggesting that the stimulatory effect is mediated through an acetylcholine like mechanism.…”

“…Calcium channel blocking effect of the test substances were confirmed by the previously reported method (Gilani et al, 2005). The isolated rabbit jejunum preparations were allowed to stabilize in normal Tyrode's solution, which were subsequently replaced with Ca 2+ -free Tyrode's solution to which EDTA (0.1 mM) was added for 30 min, in order to remove calcium from the tissues.…”