A review on ethnobotany, phytochemistry and pharmacology of Fumaria indica (Fumitory)

Gupta, Prakash C.; Sharma, Nisha; Rao, Ch. V.

doi:10.1016/s2221-1691(12)60117-8

Cited by 37 publications

(18 citation statements)

References 20 publications

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“…The alkaloids in plant species are commonly poisonous (Cortinovis & Caloni, 2015), but isoquinoline alkaloids, a large family of phytochemicals, which has also been identified in Plants (Table 4), possesses remarkable biological activities (Khan & Kumar, 2015). The presence of F. officinalis in Plants enriched the mixture by the isoquinoline alkaloids fumaricine (762.25 µg/g DM) and fumariline (835.89 µg/g DM), both bioactive components that contribute to a wide range of important pharmacological activities as anti‐inflammatory, neuropharmacological or antibacterial components (Gupta, Sharma, & Rao, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Petrič

Mravčáková

Kucková

et al. 2020

Animal Physiology Nutrition

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The objective of this study was to determine the effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) and dietary substrates containing a mix of the plants on the end products of in vitro ruminal and intestinal fermentation, rumen protozoan population and ruminal antioxidant capacity of sheep. The experiment consisted of fermentations with the four plants used individually as the sole substrate and fermentation of a mix of medicinal plants (Plants): meadow hay:barley grain (MH:B), 700/300 w/w and Plants:MH:B, 100/600/300 w/w/w. The experiment was conducted using the in vitro gas production technique (IVGPT) with 35 ml of buffered inocula and approximately 250 mg (DM basis) of substrate incubated for 24 hr at 39°C in anaerobic conditions. Quantitative analyses of the bioactive compounds by ultra‐high‐resolution mass spectrometry in Plants identified three main groups: flavonoids (22 mg/g DM), phenolic acids (15 mg/g DM) and alkaloids (3 mg/g DM). The total antioxidant capacity (TAC) of the plant extracts and rumen fluid was analysed using a ferric reducing antioxidant power assay. The values of total and individual short‐chain fatty acids, acetate:propionate ratio, pH and total gas production were significantly affected by the single plant substrates and inocula (p < .001). Apart from these parameters, the values of ammonia N, methane production and total gas produced were decreased in Plants:MH:B in comparison with MH:B (p < .001). A positive correlation was recorded between total polyphenols content and TAC of plant extracts (R2 = .778, p < .001). The counts of the total ciliate protozoan population in rumen fluid after 24 hr of fermentation were not significantly different (p > .05). Results suggest that the dietary substrate containing the medicinal plant mix possessed strong ruminal antioxidant capacity, had the potential to reduce methane emission and ammonia concentration and caused desirable changes in the gastrointestinal ecosystem.

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Section: Discussionmentioning

confidence: 99%

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Petrič

Mravčáková

Kucková

et al. 2020

Animal Physiology Nutrition

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“…The plant is now commonly known as "Pitpapda" in India, and as "Shahtra papra" in Pakistan [11,12]. Its diverse currently known medicinal uses are often in agreement with, or justified by, its broad spectrum of therapeutically interesting pharmacological activity profile unraveled mainly during the 20th century [11,13]. However, many questions concerning the details of its botanical identity, chemical constituents, bioactivities, and more appropriate medicinal values still remain to be more properly answered in terms of modern sciences.…”

Section: Historical Backgroundmentioning

confidence: 99%

Holistic Psychopharmacology of Fumaria indica (Fumitory)

Shakya¹,

Chatterjee²,

Kumar³

2012

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Fumaria indica is a medicinal plant of the fumitory family wildly growing throughout India. Classical texts of Ayurveda, i.e. the oldest traditionally known health care and medical system originating in Indian subcontinent, mentions diverse medicinal uses of the plant. During more recent decades broad spectrums of therapeutically interesting pharmacological properties of its extracts and secondary metabolites have also been reported. Recent observations made during efforts to define its pharmacological activity profile according to the Ayurvedic concepts of mind body medicine have revealed exceptionally broad spectrums of psychopharmacological activity profiles of diverse types of hydro alcoholic extracts of the plant. These effects of the extracts become apparent after their repeated daily doses only. Taken together with prior preclinical knowledge on the plant, these observations strongly suggest that Fumaria indica could be an easily available source for discovering and developing phyto-pharmaceuticals or drugs potentially useful for treatments of mental health problems commonly associated with numerous physical disorders and chronic diseases. Since several psychoactive and other phytochemical of Fumaria indica are also encountered in other plants commonly used in Chinese and other traditionally known medical systems, observations made and the holistic strategy used for defining its psychopharmacological activity profile could be of interest of others involved in efforts necessary for proper understanding of therapeutic potentials of many plants containing Fumaria alkaloids and other bioactive phytochemicals present in Fumaria indica.

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“…Fumaria indica has been reported to possess various pharmacological and therapeutic activities, including but not limited to, antioxidant, hepatoprotective, anti-lipid peroxidative, and nephroprotective (Gupta, Sharma, & Rao, 2012). Costus speciosus was reported as a diuretic and anti-inflammatory agent, besides being a sound treatment for urinary diseases.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological studies on the efficacy of a thymoquinone‐containing novel polyherbal formulation against cisplatin‐induced hepatorenal toxicity in rats

Abuzinadah

Ahmad

2019

J Food Biochem

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The aim of this study was to investigate the protective effect of a novel polyherbal formulation against cisplatin-induced hepatorenal toxicity in six groups of rats. Group I: Normal control; Group II: cisplatin (5 mg/kg i.p.); Group III: cisplatin (5 mg/kg i.p.) + cystone (750 mg/kg p.o.); Group IV: cisplatin + Costus speciosus, Fumaria indica, Cichorium intybus, and thymoquinone (CFCT) (25 mg/kg p.o.); Group V: cisplatin + CFCT-50; Group VI: cisplatin + CFCT-100. The rats were treated for 4 weeks. Serum and tissue biochemical parameters were assessed. The results showed that aspartate aminotransferase (131.8 IU/L), alanine aminotransferase (66.75 IU/L), alkaline phosphatase (168.67 IU/L), cholesterol (135.15 IU/L), serum urea (56.76 mg/dl), blood urea nitrogen (47.52 mg/dl), and creatinine (3.11 mg/dl) were significantly elevated (p < .001), while total protein (79.02 g/L) was reduced (p < .001) in the cisplatin group. These results were complemented by the outcomes of antioxidant parameters.Finally, CFCT formulation significantly ameliorated cisplatin toxicity. Practical applicationsIn this study, it is revealed that the administration of novel polyherbal formulation (Costus speciosus, Fumaria indica, Cichorium intybus, and thymoquinone [CFCT]) containing Costus speciosus, Fumaria indica, Cichorium intybus, and thymoquinone ameliorated cisplatin-induced hepatorenal injury in rats. The ameliorative effects against cisplatin toxicity could be via contributing to the antioxidant defense system, by scavenging free radicals and reducing oxidative stress and inflammatory responses. This study aimed at being beneficial to cancer's patients, as they are compelled to take cisplatin, and ultimately suffer from the consequences of irreversible nephrotoxic damage. Furthermore, CFCT formulation could be considered as a dietary supplement for the reduction of cisplatin-induced hepatorenal toxicity in cancer patients on cisplatin treatment. However, further clinical study is necessary.

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A review on ethnobotany, phytochemistry and pharmacology of Fumaria indica (Fumitory)

Cited by 37 publications

References 20 publications

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Holistic Psychopharmacology of <i>Fumaria indica</i> (Fumitory)

Pharmacological studies on the efficacy of a thymoquinone‐containing novel polyherbal formulation against cisplatin‐induced hepatorenal toxicity in rats

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A review on ethnobotany, phytochemistry and pharmacology of Fumaria indica (Fumitory)

Cited by 37 publications

References 20 publications

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Holistic Psychopharmacology of &lt;i&gt;Fumaria indica&lt;/i&gt; (Fumitory)

Pharmacological studies on the efficacy of a thymoquinone‐containing novel polyherbal formulation against cisplatin‐induced hepatorenal toxicity in rats

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Holistic Psychopharmacology of <i>Fumaria indica</i> (Fumitory)