Pharmacological and Toxicological Study ofMaytenus ilicifoliaLeaf Extract. Part I - Preclinical Studies

Abstract

One of the Brazilians medicinal plants most cited in ethnopharmacological surveys for the treatment of ulcers and gastric diseases was evaluated for its efficacy and toxicity. Maytenus ilicifolia leaf extract (MIE) was acutely and chronically (180 days) administered to rats, mice, and dogs. Acute tests were antiulcer effect and toxicological trials (observational pharmacological screening, LD50, motor coordination, sleeping time and motor activity). Chronic tests were the following: weight gain/loss and behavioral parameters in rats and mice; estrus cycle, effects on fertility, and teratogenic studies in rats and mutagenic features in mice, in addition to the Ames and micronucleus test. The following parameters were assessed in dogs: weight gain/loss, general physical conditions, water/food consumption, and anatomopathological examination of the organs subsequent to the 180-day treatment. The results showed a clear antiulcer activity for MIE from 70 mg/kg and an absence of toxicological effects in the three animal species, even if given in high doses or over a long period. The present results confirm the antiulcer property and absence of toxicological effects in three animal species of MIE, which is in line with its current popular medicinal use. Copyright © 2017 John Wiley & Sons, Ltd.

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

“…Among its pharmacological activities, anti-ulcerogenic activity stands out, which can be compared to the action of ranitidine and cimetidine. 45 Tabach et al demonstrated in important preclinical 46 and clinical 47 studies the toxicological safety and therapeutic efficacy in humans following the use of standardized M. ilicifolia extract. H 2 receptor antagonists like ranitidine, cimetidine, reversibly, and competitively inhibit histamine binding while proton pump inhibitors like omeprazole and pantoprazole by inhibiting gastric acid secretion.…”

Propriedades Fitoquímicas e Perspectivas do Melhoramento Genético de Maytenus ilicifolia Mart. ex Reissek: Revisão de Literatura

“…Em ambos os estudos, segundo os autores, foram constatadas propriedades curativas cicatrizantes das úlceras gástricas e antimicrobianas para o controle da Helicobacter pylori. Estudos mais recentes corroboram a ação da espinheira santa na redução de problemas gástricos (PÉRICO et al, 2018;TABACH et al, 2017). Pessuto et al (2009) identificaram em folhas de M. ilicifolia a presença de procianidina B 1 (epicatequina-(4β→8)-catequina) e procianidina B 2 (epicatequina-(4β→8)epicatequina).…”

Cultivo de Plantas Frutíferas

“…Os pacientes foram acompanhados em relação ao perfil bioquímico, funções psicomotoras e reações adversas. Os resultados demostram que mesmo em altas dosagens o extrato é bem tolerado, com poucas mudanças no perfil bioquímico, hematológico, função psicomotora e sem reações adversas significantes(TABACH et al, 2017)…”