Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms

Ramazani, Elham; Akaberi, Maryam; Emami, Seyed Ahmad; Tayarani‐Najaran, Zahra

doi:10.1016/j.lfs.2022.120728

Cited by 36 publications

(17 citation statements)

References 75 publications

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“…ABS, a sesquiterpene alcohol, is a natural hydrophobic bioactive compound with various effects, including antioxidant and antibacterial activities [28][29][30]32,33]. However, its application in the bio-industry, such as in functional foods, pharmaceuticals, and cosmetics, is difficult owing to its low solubility and stability in the aqueous phase [28][29][30][31]37].…”

Section: Characterization Of Abs@npsmentioning

confidence: 99%

“…In this study, we focused on α-bisabolol (ABS), a natural bioactive compound with antioxidant and antibacterial properties. ABS is a naturally occurring sesquiterpene alcohol that is widely present in plant sources, such as Matricaria chamomilla, and several studies have indicated that it has useful pharmacological and cosmetic activities, including antiinflammatory, anti-irritant, anti-tumor, antioxidant, antibacterial, and anti-allergic properties [28][29][30][31][32][33]. However, owing to the insolubility of ABS in water, its bioavailability is low, and it is difficult to develop a bioproduct based on ABS due to its lipophilicity [28,[34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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Facile Fabrication of α-Bisabolol Nanoparticles with Improved Antioxidant and Antibacterial Effects

Kim

Yu²,

Kim³

et al. 2023

Antioxidants

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Bioactive compounds are widely used in the bio-industry because of their antioxidant and antibacterial activities. Because of excessive oxidative stress, which causes various diseases in humans, and because preservatives used in bioproducts cause allergies and contact dermatitis, it is important to use natural bioactive compounds in bioproducts to minimize oxidative stress. α-bisabolol (ABS) is a natural compound with both antioxidant and antibacterial properties. However, its water-insolubility makes its utilization in bioproducts difficult. In this study, ABS-loaded polyglyceryl-4 caprate nanoparticles (ABS@NPs) with improved aqueous stability and ABS loading were fabricated using an encapsulation method. The long-term stability of the ABS@NPs was analyzed with dynamic light scattering and methylene blue-staining to determine the optimized ABS concentration in ABS@NPs (10 wt%). The ABS@NPs exhibited excellent antioxidant activity, according to the 2,2-diphenyl-1-picrylhydrazyl assay and in vitro reactive oxygen species generation in NIH-3T3 fibroblast cells, and an outstanding antibacterial effect, as determined using the Staphylococcus aureus colony-counting method. Furthermore, we evaluated the biocompatibility of the ABS@NPs in vitro. This study suggests that ABS@NPs with improved antioxidant and antibacterial properties can be used to treat diseases related to various oxidative stresses and can be applied in many fields, such as pharmaceuticals, cosmetics, and foods.

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Section: Characterization Of Abs@npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of α-Bisabolol Nanoparticles with Improved Antioxidant and Antibacterial Effects

Kim

Yu²,

Kim³

et al. 2023

Antioxidants

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“…We can apply rice bran to food, animal feed, and fertilizer but discard most of the bran. Recently, we have paid much attention to rice bran because of the various pharmacological properties of its ingredients [19][20][21]. We separate into gum, wax, dark oil, and scum at different boiling temperatures, and further extraction yields many chemicals with biological activities.…”

Section: Functional Ingredients In Rice 21 Functional Ingredients In ...mentioning

confidence: 99%

“…γ-oryzanol is a potent functional ingredient in the nonsaponifiable fraction of rice bran. γ-oryzanol is bound in 4 chemical forms to ferulic acid and thus belongs to the family of ferulated sterols [20,21]. The solubility of γ-oryzanol is only 0.06% in water and 0.2% in 20% ethanol.…”

Section: Functional Ingredients In Rice 21 Functional Ingredients In ...mentioning

confidence: 99%

The Potential Health Benefits of Brown Rice

Watanabe¹

2023

Sustainable Rice Production - Challenges, Strategies and Opportunities

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In many countries, rice contributes to better health by supplying dietary energy, proteins, fat, and various micronutrients. Many different rice species are cultivated in Japan and other rice-producing countries, in which we expect some varieties to prevent many diseases. In particular, the health effects of brown rice are apparent. In particular, rice bran ingredients accumulated evidence about their physiological and pharmacological activity. The Japanese diet has become a world heritage and famous worldwide, but knowledge about the benefits of rice eating is limited. Here, we would like to focus on the benefits of eating brown rice and recently developed low-protein fermented brown rice (LPFG) to improve the gut-kidney axis’s negative spiral in kidney disease patients. Other potential benefits of brown rice are the suppression of dementia and celiac disease. The category of “medical rice” represents the health effects of rice eating.

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“…α-(−)-bisabolol (hereafter denoted as bisabolol [ 65 ]) is an organic molecule (a sesquiterpene alcohol) and a natural component of chamomile oil ( Matricaria spp.) ( Figure 1 ) [ 65 , 66 , 67 ]. It has been shown that bisabolol is the predominant constituent of Matricaria chamomilla [ 68 ].…”

Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

2022

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Hydroxyapatite, Ca5(PO4)3(OH), is a biomimetic active ingredient, which is used in commercial oral care products such as toothpastes and mouthwashes worldwide. Clinical studies (in vivo) as well as in situ and in vitro studies have shown the preventive effects of hydroxyapatite in various field of oral care. In some products, hydroxyapatite is combined with other active ingredients, to achieve an additional antibacterial effect or to promote gum health. This review analyzes the efficacy of six selected natural and nature-inspired ingredients that are commonly used together with hydroxyapatite. These additional actives are either antibacterial (lactoferrin, xylitol, and zinc) or promote gum health (allantoin, bisabolol, and hyaluronic acid). A systematic literature search was performed, and all studies found on each ingredient were analyzed. In summary, all analyzed ingredients mentioned in this review are well described in scientific studies on their beneficial effect for oral health and can be used to expand the preventive effect of hydroxyapatite in oral care products.

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Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms

Cited by 36 publications

References 75 publications

Facile Fabrication of α-Bisabolol Nanoparticles with Improved Antioxidant and Antibacterial Effects

Facile Fabrication of α-Bisabolol Nanoparticles with Improved Antioxidant and Antibacterial Effects

The Potential Health Benefits of Brown Rice

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

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