Pharmacological activities of the organic extracts and fatty acid composition of the petroleum ether extract from Haplophyllum tuberculatum leaves

Hamdi, Abdelaziz; Majouli, Kaouther; Abdelhamid, Amal; Marzouk, Belsem; Belghith, Hèla; Chraief, Imed; Bouraoui, Abderrahman; Marzouk, Zohra; Heyden, Yvan Vander

doi:10.1016/j.jep.2018.01.012

Cited by 18 publications

(24 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Palmitic was found to be the major saturated fatty acids in the current investigated plant. It was reported that extract was rich in palmitic acid showed gastroprotective activity against HCl/ethanol-induced gastriculcer in rats (Hamdi et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Fahmi¹,

Abdur-Rahman²,

Naser³

et al. 2019

Heliyon

View full text Add to dashboard Cite

Pulicaria undulata subsp. undulata (Family; Asteraceae) is a medicinal plant used to treat inflammation. The objective of this study is to explore the protective effect of the ethanol extract of P. undulata subsp. undulata aerial parts against ethanol induced gastric ulcer in rats. The chemical composition of plant extract, the unsaponifiable matter and the fatty acid methyl esters were analyzed. The biological evaluation was carried out through measuring ulcer indices, oxidative stress markers, certain marker enzymes, inflammatory index and the histopathological assessment of the stomach in rats. The total unsaponifiable matter (94.29%) and the fatty acid methyl ester (82.96%) content were identified. Gastric ulcer recorded significant increase in gastric volume and lesion counts (p < 0.0001). Drastic changes in all biochemical parameters under investigation were observed. Protection with plant extract reversed the action of ethanol by variable degrees of improvement in comparison with the reference drug. The presence of carbohydrates and proteins that acted as a mucilage lining the stomach inner wall give its protective action. In conclusion, P. undulata subsp. undulata succeeded to have anti-ulcerative protective effect. The measured biomarkers served as a good mirror to predict gastric ulcer and the presence of carbohydrates, protein and fibers present in the plant extract acted as a mucilage lining the inner intestinal wall and protect against ethanol induced gastric ulcer. Future study will be carried out to identify the biologically active compounds responsible for plant protection against the gastric ulcer.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Fahmi¹,

Abdur-Rahman²,

Naser³

et al. 2019

Heliyon

View full text Add to dashboard Cite

show abstract

“…Likewise, palmitic acid was previously reported in family Lamiaceae [16], but detected for the first time in this genus. It had various biological activities as anti-inflammatory and analgesic [19]. Furthermore, it showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal HDF cells.…”

Section: Gc/ms Analysis Of Fatty Acid Methyl Estersmentioning

confidence: 99%

Phytochemical investigation of saponifiable matter & volatile oils and antibacterial activity of Moluccella laevis L., family Lamiaceae (Labiatae)

Hamed

Ahmed

Attia

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

View full text Add to dashboard Cite

The current study was aimed to evaluate some parts of Moluccella laevis viz., phytochemical and antibacterial. Regarding to GC/MS of the saponifiable matters of petroleum ether fraction of total ethanolic extract of the aerial parts (TEE), the main recognized unsaturated fatty acids were methyl linolenate (25.58%) and methyl linoleate (15.87%). Whereas, the major saturated fatty acids were, palmitic (25.4%) followed by stearic acid (10.48). A comparative analysis of the volatile constituents of M. laevis flowers and leaves was performed by Head Space GC/MS. The volatile mixtures of both plant parts displayed comparable amounts of hydrocarbons and oxygenated compounds, with a noticeable greater contribution of the latter in the leaves.Besides, -pinene (40.84%), chrysanthenyl acetate (17.89%) and isobornyl acetate (10.64%), were identified as the major volatile components in the flowers. While, isobornyl acetate (35.09%) was characterized as the major constituent followed by, 2-methyl-4-butanolide (22.12%), 1-heptene oxide (7.47%) and benzoic acid, methyl ester (4.05%) of the volatile oil composition of the leaves. Moreover, this study included the antibacterial activity of TEE and its different fractions against Gram positive and negative bacteria. TEE exhibited MIC values of 326 476, and 541 µg/mL against E. coli, K. pneumonia and P. aeruginosa, respectively, while the aqueous fraction showed

show abstract

“…Haplophyllum tuberculatum is a perennial herb distributed throughout North Africa and the Middle East. In Sudan, the plant is locally known as Haza, and the aerial parts have been used traditionally to treat malaria, asthma, kidney diseases, gynecological and bowel disorders [10,11]. Anti-inflammatory, antioxidant, antibacterial, and antifungal activities have been reported [10][11][12], and alkaloids, flavonoids, coumarins and lignans have been identified [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…In Sudan, the plant is locally known as Haza, and the aerial parts have been used traditionally to treat malaria, asthma, kidney diseases, gynecological and bowel disorders [10,11]. Anti-inflammatory, antioxidant, antibacterial, and antifungal activities have been reported [10][11][12], and alkaloids, flavonoids, coumarins and lignans have been identified [13][14][15]. The methanolic extract of the aerial part and roots of H. tuberculatum possessed activity against P. falciparum [16], and Justicidin A was found active [17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lignans, Amides, and Saponins from Haplophyllum tuberculatum and Their Antiprotozoal Activity

et al. 2020

View full text Add to dashboard Cite

A screening of Sudanese medicinal plants for antiprotozoal activities revealed that the chloroform and water fractions of the ethanolic root extract of Haplophyllum tuberculatum exhibited appreciable bioactivity against Leishmania donovani. The antileishmanial activity was tracked by HPLC-based activity profiling, and eight compounds were isolated from the chloroform fraction. These included lignans tetrahydrofuroguaiacin B (1), nectandrin B (2), furoguaiaoxidin (7), and 3,3′-dimethoxy-4,4′-dihydroxylignan-9-ol (10), and four cinnamoylphenethyl amides, namely dihydro-feruloyltyramine (5), (E)-N-feruloyltyramine (6), N,N′-diferuloylputrescine (8), and 7′-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11–13. Compounds 1, 2, and 5–13 are reported for the first time from Haplophyllum species and the family Rutaceae. The antiprotozoal activity of the compounds plus two stereoisomeric tetrahydrofuran lignans—fragransin B2 (3) and fragransin B1 (4)—was determined against Leishmania donovani amastigotes, Plasmodium falciparum, and Trypanosoma brucei rhodesiense bloodstream forms, along with their cytotoxicity to rat myoblast L6 cells. Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 µM) and the highest selectivity index (25.5).

show abstract

Pharmacological activities of the organic extracts and fatty acid composition of the petroleum ether extract from Haplophyllum tuberculatum leaves

Cited by 18 publications

References 47 publications

Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Phytochemical investigation of saponifiable matter & volatile oils and antibacterial activity of Moluccella laevis L., family Lamiaceae (Labiatae)

Lignans, Amides, and Saponins from Haplophyllum tuberculatum and Their Antiprotozoal Activity

Contact Info

Product

Resources

About