Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Fahmi, Abdelgawad A.; Abdur-Rahman, Mariam; Naser, Asmaa F Aboul; Hamed, Manal A.; Abd‐Alla, Howaida I.; Shalaby, Nagwa M. M.; Nasr, Mohamed I

doi:10.1016/j.heliyon.2019.e01359

Cited by 21 publications

(13 citation statements)

References 47 publications

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“…Although it has been used in traditional medicine for a long time, it has become a topic of interest for medicinal research since the 1980s [ 16 ]. Previous studies have shown that P. crispa derivatives exert antioxidative [ 17 ], anti-inflammatory [ 18 ], and chemopreventive activities [ 19 ]. A phytochemical screening of P. crispa extract attributed these effects to the presence of coumarins, tannins, and flavonoids [ 18 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, extracts from the Pulicaria species have been shown to inhibit neutrophil infiltration and alleviate oxidative stress. It was also postulated that it suppresses the generation of nitric oxide [ 27 ] and modulates the expression of intracellular adhesion molecule-1 (ICAM-1), tumor necrosis factor- (TNF-) α [ 18 ], and prostaglandin E2 [ 18 ]. Therefore, further study of their effects on the immune system, especially at the molecular level, will be particularly insightful.…”

Section: Introductionmentioning

confidence: 99%

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In VitroStudies on the Immunomodulatory Effects ofPulicaria crispaExtract on Human THP-1 Monocytes

Albrahim

Alnasser

Al-Anazi

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Pulicaria crispa (P. crispa) is a plant from the Compositae family that exhibits antioxidant, anti-inflammatory, antibacterial, and cytotoxic activities. Objective. The current study aimed at investigating the immunomodulatory effects of P. crispa extract in lipopolysaccharide- (LPS-) stimulated human monocytic THP-1 cells. Methods. To induce macrophage differentiation, THP-1 cell lines were treated with phorbol-12-myristate 13-acetate, followed by exposure to LPS with or without 50 or 100 μg/ml of P. crispa extract. The following tests were employed to test the immunomodulatory effects of the extract: MTT assay, ELISA, Western blotting analysis, cell migration and phagocytosis assays, and Annexin V staining method. Results. Exposure to 100 μg/ml P. crispa extract significantly reduced THP-1 cell proliferation, migration, and phagocytosis (in LPS-stimulated cells, but not in unstimulated cells). Moreover, the extract alone significantly reduced the rate of THP-1 cell apoptosis, while it increased the rate of late apoptosis. Molecular investigations showed that treatment with P. crispa extract significantly upregulated the expression of ERK1, p-MAPK, P-P38, and Bcl2, while it significantly reduced the expression of ERK5, Bax, NF-κB, P-NF-κB, CCL1, CCL2, CCL5, CCL22, CXCL1, and CXCL10. Conclusion. Pulicaria crispa extract exhibited anti-inflammatory, antiproliferative, antimigratory, and antiphagocytic effects in LPS-stimulated THP-1 cells. Future studies should investigate these mechanisms in animal models with chronic inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In VitroStudies on the Immunomodulatory Effects ofPulicaria crispaExtract on Human THP-1 Monocytes

Albrahim

Alnasser

Al-Anazi

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…The presence of phenolic compounds, including flavonoids, seemingly plays a prominent role in the plant’s protection against oxidative stress in its saline habitat and, consequently, a strong antioxidant behavior is observed in the plant’s extract. These compounds are also reported to be beneficial as part of the extract in treating inflammatory disorders [ 35 ]. The LC-MS analysis also revealed the similarities in the presence of phytochemical constituents, to a certain extent, between the P. undulata , and other Pulicaria species (i.e., P. crispa and P. incisa ), which have shown presence of similar phenolics, and flavonoid contents (i.e., quercetin, kaempferol, and caffeic acid) [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…For example, the presence of flavonoids and phenolic acids, sterols, and fatty acids are reported from several Pulicaria and other halophytic species [ 5 , 28 , 29 , 30 ]. Antioxidant and other physiological and hemostasis-related parameters—specifically in the context of soil, trace elements in the soil, generated salinity stress, habitat adaptation, and production and higher accumulation of phytoconstituents—have been found [ 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Profile, Antioxidant, Antimicrobial, and Anticancer Activities of the Water-Ethanol Extract of Pulicaria undulata Growing in the Oasis of Central Saudi Arabian Desert

Mohammed

Al-Omar

Khan

et al. 2021

Plants

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Pulicaria undulata (L.) C. A. Mey has multiple uses as part of traditional medicament, and several biological activities of the plant have been corroborated in the scientific literature. The current work evaluates the phytochemical constituents and biological properties of the water-ethanol extract of the P. undulata growing in Qassim, the central arid regions of Saudi Arabia. Qualitative UPLC-ESIQ-TOF analysis identified 27 compounds belonging to the phenolics, flavonoids, triterpenes, coumarins, and fatty acids chemical class. The quantitative analysis exhibited 33.3 mg/g GAE (Gallic Acid Equivalents), and 10.8 mg/g QE (Quercetin Equivalent) of the phenolics and flavonoids in the plant’s concentrated (to dryness) water-ethanol extract. The trace elements analysis of the plant’s dry powder established the presence of copper (20.13 µg/kg), and zinc (68.2 µg/kg) in the higher levels of occurrences. In terms of the antioxidant potential of the plant’s extract, the ferric-reducing, and free-radicals scavenging activities were recorded at 47.11 mg/g, and 19.13 mg/g equivalents of the concentrated to dryness water-ethanol extract of the plant. The water-ethanol extract of P. undulata also exhibited antimicrobial activity against the tested Gram-positive bacteria, while no activity was observed against the tested Gram-negative bacteria, or the fungi. The MIC (minimum inhibitory concentration) values were in the range of 49 to 1563 µg/mL, whereas the MBC (minimum bactericidal concentration) values ranged from 49 to 3125 µg/mL, against the tested Gram-positive bacteria. The P. undulata water-ethanol extract also exhibited potent cytotoxic effects with the IC50 value at 519.2 µg/mL against the MCF-7 breast cancer cell-lines, followed by the anticancer activity of erythroleukemic cell-lines, K562 at 1212 µg/mL, and pancreatic cell-lines, PANC-1, at 1535 µg/mL, as compared to the normal fibroblast cells (4048 µg/mL). The Annexin-V assay demonstrated that, as the P. undulata extract’s dose increased from IC50 to twice of the IC50, the percentage of necrosis was found to be increased in the late apoptosis of the cancer cells. These data confirmed the P. undulata extract’s ability to inhibit several human cancer cell lines’ growth in comparison to other local halophytes. The antimicrobial activity of the plant was also confirmed.

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“…et al,21 . Identification of active ingredient of PJ methanolic extract and its fractions was carried out by Al-Naqeb et al,12 , they have reported the presence of catechin-like compounds, mainly in the methanolic extract and its dichloromethane fraction and both have…”

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confidence: 96%

Anti-Obesity Effects of Pulicaria Jaubertii E. Gamal-Eldin in High Fat Diet-Induced Rats

2020

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Background: Pulicaria jaubertii E. Gamal-Eldin is a traditional medicine and flavoring used in Yemen where a large number of people depend on herbal plants to treat their ailments. This study was conducted to determine and compare the effects of Pulicaria jaubertii leaves and flowers aqueous extract (PJAE) and Pulicaria jaubertii leaves and flowers in powder form mixed with diet (PJPD) on obesity induced rats by high-fat diet (HFD). Methods: Obesity was experimentally induced in male Sprague Dawley rats by feeding them a high-fat diet for 6 weeks. The rats were divided into 3 groups, the HFD control group, whereas the rats fed HFD only and the PJAE group where the rats fed HFD + PJAE and PJPD where the rats fed HFD + PJPD. PJAE was administrated by gavage at 1g/kg body weight and the activity of PJPD was determined as oral administration at 10% of the diet. Food intake and gain weight were taken once a week and blood samples were obtained at the end of the experiment for lipid profile analysis, glucose level and toxicity parameter including liver and kidney functions parameters. Results: The results indicated a significant decrease in the percentage of weight gain and in the PJPD group at the fifth and sixth weeks of treatment compared to the HFD control rats. Also, there was a significant decrease in the level of blood triglycerides in the PJPD compared to the HFD group. Where no significant change was observed in the percentage of weight gain and triglyceride level in the PJAE group compared to the HFD control rats. Also, there was no significant changes in all the tested parameters including, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, liver enzymes and creatinine and urea levels. Conclusion: The results obtained from this study showed that the leaves and flowers of Pulicaria jaubertii mixed with HFD had an anti-obesity effect in rats fed with HFD, and the anti-obesity effects of PJ could be attributed to the phytochemicals present. Therefore, the current study scientifically confirms the traditional use of PJ as a potential candidate for body weight loss. Peer Review History: Received: 7 September 2020; Revised: 11 October; Accepted: 25 October, Available online: 15 November 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. Gulam Mohammed Husain, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, gmhusain@gmail.com Comments of reviewer(s): Similar Articles: ASSESSMENT OF THE RISK OF TYPE 2 DIABETES AMONG HEALTHY WITHOUT DIABETES IN SUDAN USING THE FINDRISC TOOL

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Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

Cited by 21 publications

References 47 publications

In VitroStudies on the Immunomodulatory Effects ofPulicaria crispaExtract on Human THP-1 Monocytes

In VitroStudies on the Immunomodulatory Effects ofPulicaria crispaExtract on Human THP-1 Monocytes

Chemical Profile, Antioxidant, Antimicrobial, and Anticancer Activities of the Water-Ethanol Extract of Pulicaria undulata Growing in the Oasis of Central Saudi Arabian Desert

Anti-Obesity Effects of Pulicaria Jaubertii E. Gamal-Eldin in High Fat Diet-Induced Rats

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