Pharmacokinetics of the Hypnotic Benzodiazepine, Temazepam

Bittencourt, P. R. M.; Richens, A.; Toseland, P. A.; Wicks, J.F.C.; Latham, A. N.

doi:10.1111/j.1365-2125.1979.tb00453.x

Cited by 31 publications

(7 citation statements)

References 6 publications

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“…When given orally in doses of 10 to 40 mg at night, peak plasma concentrations are reached after less than 60 min, and after 9 h the plasma concentration has fallen to 20% of the peak value (Fuccella et al, 1977;Bittencourt et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

Human orthostatic reflexes after taking temazepam at night.

Patrick

Dikshit

Macdonald

et al. 1987

Brit J Clinical Pharma

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Section: Introductionmentioning

confidence: 99%

Human orthostatic reflexes after taking temazepam at night.

Patrick

Dikshit

Macdonald

et al. 1987

Brit J Clinical Pharma

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“…Temazepam is known in adults to have a short half-life and to reach a maximum serum concentration 20 rain following oral administration [1,4]. It is frequently used by adults as an oral hypnotic which rapidly induces sleep at a dose of 10 mg [1,2].…”

Section: Discussionmentioning

confidence: 99%

Problems encountered using temazepam syrup for sedation in infants

1988

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Six infants with a history of wheezing were given temazepam syrup as sedation, to allow lung function tests to be performed. Despite doses ranging from 2.5 mg/kg-4.5 mg/kg only one infant remained a sleep for 1 h, the time taken for full lung function to be assessed. All other infants awoke within 15 min before test could be completed. Three infants developed hiccoughs and three were very irritable after awaking from sedation.

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“…The present study investigated the effects of 6 nights' treatment with nitrazepam (10 mg) and temazepam (20 mg) on human performance. Temazepam, a benzodiazepine with an elimination halflife of 8-15 h (Bittencourt et al, 1979;Jochemsen & Breimer, 1982), has been demonstrated to be effective as an hypnotic (Nicholson & Stone, 1976;Hindmarch, 1976) and to be free of morning-after residual effects in doses up to 30 mg (Harry & Latham, 1980). Nitrazepam, a benzodiazepine with a long elimination half-life (18-31 h;Reider & Wendt, 1973), has been shown to produce residual effects the morning after an evening dose of 5-10 mg (Ogara etal., 1980), but has been reported to be effective as an hypnotic for a period of up to 24 weeks (Oswald et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance.

Tedeschi¹,

Griffiths²,

Smith³

et al. 1985

Brit J Clinical Pharma

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1 The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion, choice reaction time and on subjective feelings were studied in a double blind cross-over study in eight volunteers. 2 Testing was performed on nights 1 and 6 of treatment. 3 Nitrazepam, a benzodiazepine with a long elimination half-life produced a residual performance impairment on night 1 that had disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination half-life produced no significant performance impairment on night 1, but by night 6 a significant impairment of saccadic eye movements (P < 0.05), was seen 1 h after drug intake. 4 We conclude that tolerance developed to the sedative action of nitrazepam over the 6 night period of the study. No evidence of tolerance was seen with temazepam.

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Pharmacokinetics of the Hypnotic Benzodiazepine, Temazepam

Cited by 31 publications

References 6 publications

Human orthostatic reflexes after taking temazepam at night.

Human orthostatic reflexes after taking temazepam at night.

Problems encountered using temazepam syrup for sedation in infants

The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance.

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