Pharmacokinetics of lincomycin following intravenousadministration in febrile goats

Sharma, Meemansha; Dumka, V. K.

doi:10.18805/ijar.v0iof.6834

Cited by 3 publications

(4 citation statements)

References 15 publications

(29 reference statements)

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“…Elimination half-life (3.98 AE 0.18 h), Cmax (9.24 AE 1.2 μg/ml), MRT (4.13 AE 0.16 h), Vdss (1.22 AE 0.06 L/kg) and Clb (0.24 AE 0.01 l/h/kg) of enrofloxacin (5 mg/kg) have been reported [6]. The Vd (3.35 AE 0.45 L/kg), Clb (0.28 AE 0.03 l/h/kg) and T 1 / 2 β (9.99 AE 2.83 h) suggest long persistence of lincomycin in goat as it can be repeated every 24 h with MIC (0.6 μg/ml) for treatment of febrile bacterial infections in goats [33]. But intramuscular lincomycin can be administered every 12 h [34].…”

Section: Comparative Pharmacokinetics Of Antimicrobials In Domestic Gmentioning

confidence: 98%

“…The Vd (3.35 AE 0.45 L/kg), Clb (0.28 AE 0.03 l/h/kg) and T 1 / 2 β (9.99 AE 2.83 h) suggest long persistence of lincomycin in goat as it can be repeated every 24 h with MIC (0.6 μg/ml) for treatment of febrile bacterial infections in goats [33]. But intramuscular lincomycin can be administered every 12 h [34].…”

Section: Comparative Pharmacokinetics Of Antimicrobials In Domestic Gmentioning

confidence: 99%

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Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats

Saganuwan¹

2020

Goats (Capra) - From Ancient to Modern

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Pharmacokinetics, the process that involves drug absorption, distribution, metabolism and excretion (ADME) of antimicrobials, determines pharmacodynamic response, that is, what drugs do to the body. Therefore, of all the pharmacokinetic parameters, elimination half-life (T 1 / 2 β), volume of distribution (Vd), maximum plasma concentration (Cmax) and maximum time reached (Tmax) are the most important parameters. Hence, the parameters are unique in determining pharmacokinetic and pharmacodynamic response of antimicrobials. However, it is elimination half-life and minimum inhibitory concentration (MIC) that determine the dosing interval of antimicrobials. The dose range of 2.5 mg/kg for gentamicin passing through 4 mg/kg (ciprofloxacin), 4.2 mg/kg (ampicillin L/A), 5 mg/kg (kanamycin, enrofloxacin, gatifloxacin and norfloxacin), 7 mg/kg (mequindox), 10 mg/kg (amikacin, enrofloxacin, lincomycin, pefloxacin, cefpirome, erythromycin and isoniazid), 20 mg/kg (oxytetracycline) and 30 mg/kg (metronidazole) have elimination half-life of 1.2-67.2 h, Cmax of 0.12-54.4 μg/ml, Tmax of 0.2-24 h, bioavailability of 16-99.8% and plasma protein binding of 0->80% when administered intramuscularly, intravenously and orally. Human equivalent dose formula could be used to extrapolate human-goat therapeutic doses of antimicrobials. However, some antimicrobials such as sulfadimidine, tulathromycin, oxytetracycline and azithromycin may have high residues in the milk, kidneys, liver, intestines, brain and skeletal muscles and may portend high risk of antimicrobial resistance, hypersensitivity reaction, epidermal necrolysis, Stevens-Johnson syndrome and other adverse drug reactions.

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Section: Comparative Pharmacokinetics Of Antimicrobials In Domestic Gmentioning

confidence: 98%

Section: Comparative Pharmacokinetics Of Antimicrobials In Domestic Gmentioning

confidence: 99%

Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats

Saganuwan¹

2020

Goats (Capra) - From Ancient to Modern

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“…According to our previous studies (Li et al, 2013;Yang et al, 2015), pharmacokinetics parameters were determined for each individual bird using a non-compartmental method. Following both injections, the area under the concentrationtime curve (AUC 0- ) and the first moment curve (AUMC 0- ) were calculated using the linear trapezoidal rule with extrapolation to time infinity (Sharma and Dumka, 2018); mean residence time (MRT) was then calculated as the ratio of AUMC 0- to AUC 0- (Yang et al, 2013). After intravenous injection, volume of distribution (V Z ) was determined using equation V Z = (Dose/AUC 0- )/z, where Dose is the amount of drug intravenously administered (Yang et al, 2018b); total body clearance (Cl) was calculated as the radio of intravenous Dose to AUC 0- and the volume of distribution at steady-state (V SS ) was calculated as V SS = MRT × Cl (Yang et al, 2020a).…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics of Ceftiofur Sodium in Black-bone Silky Fowl after One Single Intravenous and Intramuscular Injection

Yang

Wang

Song

et al. 2020

IJAR

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Background: Ceftiofur is a third-generation cephalosporin antibiotic developed exclusively for veterinary applications. Although not approved in China, ceftiofur is being used extensively in an extra-label manner to treat poultry infections. Black-bone silky fowl is a unique chicken breed which is different from the common chicken breeds in both morphology and other physiology. These differences may result in varied pharmacokinetic profiles. Therefore, the present study aimed to investigate the pharmacokinetics of ceftiofur (measured by ceftiofur and its active metabolites concentrations) in black-bone silky fowl following a single intravenous or intramuscular injection of ceftiofur sodium.Methods: Ceftiofur sodium was intravenously and intramuscularly given to six healthy black-bone silky fowl at the dose of 10 mg/kg body weight. A derivatization method was used to quantify the concentrations of ceftiofur and its active metabolites (expressed as desfuroylceftiofur acetamide) in plasma samples. A non-compartmental method was used to calculate the pharmacokinetics parameters. Results: The terminal half-life (t1/2lz) was calculated as 3.19±0.28 and 3.36±0.17 h following intravenous and intramuscular injections, respectively. After intravenous treatment, the total body clearance (Cl) and volume of distribution at steady state (VSS) were determined as 73.79±5.83 ml/h/kg and 318.65±30.06 ml/kg, respectively. After intramuscular injection, the peak concentration (Cmax; 22.55±0.89 ìg/ml) was observed at 1.67±0.26 h and the absorption half-life (t1/2ka) and absolute bioavailability (F) were calculated as 0.40±0.13 h and 93.03%±7.07%, respectively. The current results demonstrated the rapid and complete absorption, however, poor distribution and rapid elimination of ceftiofur and its active metabolites in black-bone silky fowl.

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“…Kim et al [5] showed that the residue of lincomycin in laying hen eggs was low, ranging from low to high doses that were orally or intravenously administered. Studies on the pharmacokinetics and concentration of lincomycin in poultry tissues have been conducted [6][7][8], suggesting that the use of lincomycin for poultry therapy is being reconsidered. After a prolonged period of disuse, lincomycin has re-emerged as a therapy for poultry in Indonesia, as reported in a study of the lincomycin-spectinomycin formulation [9].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

Wijayanti,

Muzaki,

Wibisono

et al. 2024

Vet World

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Background and Aim: Lincomycin is an antibiotic used in broiler farming and is commonly combined with other substances to achieve synergistic and complementary effects on the antibacterial spectrum and mechanism. We developed a specific high-performance liquid chromatography (HPLC) method to measure lincomycin levels in broiler tissues. This study aimed to determine the lincomycin level in tissues and compare it with the minimum inhibitory concentration (MIC) and maximum residue limit (MRL) of certain pathogenic bacteria. Materials and Methods: Three groups of broiler chickens were involved in the study (n = 20 in each group): A control group without lincomycin treatment and two groups (each further divided into two sub-groups) that received oral lincomycin at a dose of 1 g/10 kg of body weight daily for 7 and 14 consecutive days. Tissue samples were collected from each group 1 day and 1 week after lincomycin administration (ALA). This study validated the development of a technique for analyzing drug level degradation in tissues using HPLC. Descriptive and statistical analyses were performed for drug levels to assess their therapeutic value and safety based on lincomycin MIC of certain pathogenic bacteria and MRL. Results: The method validation resulted in linear regression and coefficient of determination for tissues with r2 > 0.99, with a recovery rate of 90%–110%, precision as the coefficient of variation 15%, and specificity with no peak overlap for lincomycin. The limits of detection for the liver and kidney were 0.01 μg/g, 0.05 μg/g, and 0.1 μg/g for the breast muscle and all tissues. Administration of lincomycin for 7 and 14 days resulted in therapeutic value concentrations. Lincomycin levels in the liver and kidney of ALA exceeded the MRL, whereas breast muscles were below the MRL for a week of ALA treatment. Conclusion: Administration of lincomycin for 7 and 14 consecutive days resulted in therapeutic value; however, after a week, most tissues showed high drug concentrations that exceeded the MRL. It is necessary to carefully consider the prolonged therapeutic dose of lincomycin in broilers. Antibiotic therapy must be guided in such a way as to protect the product from harmful residues. Keywords: : broiler tissues, lincomycin level, maximum residue limit, minimum inhibitory concentration.

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Pharmacokinetics of lincomycin following intravenousadministration in febrile goats

Cited by 3 publications

References 15 publications

Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats

Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats

Pharmacokinetics of Ceftiofur Sodium in Black-bone Silky Fowl after One Single Intravenous and Intramuscular Injection

Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

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