“…And absolute bioavailability ( F ) was determined as the ratio of AUC PO to AUC IV . After IV administration, the initial concentration ( C 0 ) was determined by extrapolation; the distribution volume ( V Z ) was calculated as Dose/AUC 0-∞ /λz, where Dose was the drug dose administered intravenously; systemic clearance ( Cl ) was equal to the ratio of the dose administered intravenously to the AUC 0-∞ ; and the steady state distribution volume ( V SS ) was computed as V SS = MRT × Cl ( Yang et al, 2020 ).…”