Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with
            <i>Actinobacillus pleuropneumoniae</i>

Liu, Jianzhong; Fung, Ki-Fai; Zhang-liu, Chen; Zeng, Zhenling; Jie, Zhang

doi:10.1128/aac.47.2.820-823.2003

Cited by 93 publications

(123 citation statements)

References 11 publications

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“…The calculated value of AUC for the 20 mg/kg dose of florfenicol (60.9 hr·µg/ml) is almost comparable to previous report in pigs (68.61 hr·µg/ml) [7], but is lower than another study (84.3 h·µg/ml) [5]. Other parameters as C max , T max , T 1/2 abs , T 1/2eli are significantly lower than previous reports by Liu et al (2003) and Jiang et al (2006) [5,7]. The differences in these parameters may be due to the use of different commercial preparations.…”

supporting

confidence: 76%

“…The lower peak concentration and AUC seen at higher concentration may concern residues at the injection site, though we are at the early stage to support with data the idea that residues should be considered more in combination therapy than in single therapy. The calculated value of AUC for the 20 mg/kg dose of florfenicol (60.9 hr·µg/ml) is almost comparable to previous report in pigs (68.61 hr·µg/ml) [7], but is lower than another study (84.3 h·µg/ml) [5]. Other parameters as C max , T max , T 1/2 abs , T 1/2eli are significantly lower than previous reports by Liu et al (2003) and Jiang et al (2006) [5,7].…”

supporting

confidence: 59%

“…No significant difference in all pharmacokinetic parameters was observed between the two dose levels of tylosin. The experimental data in this study was best fitted to a one compartment model in accordance with previous reports in different animals [7,13,15], though other authors preferred a non compartmental model for the same route of administration [5,9]. The elimination half life of tylosin 10 mg/kg in this study (3.01 ± 2.77 hr) is higher than the reported figures in cattle and buffaloes (2.24 and 2.4 hr, respectively) [12], but significantly lower than observations in pig [9], in the latter the mean elimination half life (T 1/2eli ) of five pigs was calculated to be greater than 24 hr.…”

mentioning

confidence: 83%

“…It has equal efficacy comparable to that of chloramphenicol, lower toxicity and less development of resistance [2]. In vivo and in vitro antibacterial activities of florfenicol against bovine and porcine respiratory pathogens have been described [7,11]. Recently, florfenicol tends to be increasingly used for treating porcine pneumonias, the main target bacteria in pigs being P.multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica and Streptococcus Suis [5,11].…”

mentioning

confidence: 99%

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Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Kim

Gebru

Chang

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Clinical pharmacokinetic profiles were investigated following intramuscular (i.m.) administration to pigs with a commercial tylosin-florfenicol combination product at a dose of 2.5 mg/kg tylosin and 5 mg/kg florfenicol or 10 mg/kg tylosin and 20 mg/kg florfenicol. The quantitation limit (QL) of florfenicol was 0.1 µg/ml, the inter-day and intra-day precision (CV%) were both beow 10%. The quantitation limit (QL) of tylosin was 0.05 µg/mL. The pharmacokinetic characteristics after i.m. doses were fitted by a one compartment open model. A fourfold decrease in the normal dose of each drug (20 mg/kg to 5 mg/kg for florfenicol, and 10 mg/kg to 2.5 mg/kg for tylosin) resulted in a corresponding two fold decrease in each drug of the maximum plasma concentration (C max ) and the area under curve (AUC) values.

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supporting

confidence: 76%

supporting

confidence: 59%

mentioning

confidence: 83%

mentioning

confidence: 99%

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Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Kim

Gebru

Chang

et al. 2008

The Journal of Veterinary Medical Science

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“…A combination of florfenicol and tylosin (2 : 1) (w/w) is currently marketed in Asia, especially in Korea, for bacterial diseases of dogs. The pharmacokinetic parameters of florfenicol (Ali et al 2003;Liu et al 2003;Park et al 2008;Koc et al 2009) and tylosin (Weisel et al 1977;Prats et al 2002;Ji et al 2013) have been thoroughly studied in different animal species including dogs. These studies have shown that florfenicol has high bioavailability and good distribution into tissues.…”

mentioning

confidence: 99%

Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs

Mechesso¹,

Lee²,

Park³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs. Minimum inhibitory concentrations were determined using the broth dilution method, whereas the checkerboard assay was used to evaluate the antibacterial effects of the combination of florfenicol and tylosin. The pharmacokinetic parameters of the two antibiotics were determined following administration of the mixture in beagle dogs. Serum concentrations of both drugs were analysed using high-performance liquid chromatography. Pharmacokinetics parameters such as area under the concentration-time curve, absolute bioavailability and systemic clearance were determined using noncompartmental analysis. The results showed that tylosin and florfenicol exerted varying degrees of antibacterial activity against the tested isolates. The combination of florfenicol and tylosin produced a synergistic and additive antibacterial effect. Analysis of the serum samples revealed a rapid and almost complete absorption of florfenicol and tylosin with mean bioavailabilities of 92.7% and 106.1%, respectively. The times needed to reach maximum concentration for florfenicol and tylosin were 1.5 and 3 h, respectively. Moreover, intramuscular injection of the mixture to beagle dogs resulted in serum concentrations that were higher than the corresponding minimum inhibitory concentrations in beagle dogs. This is the first study to report optimisation of florfenicol and tylosin doses following administration of a combination of the two drugs to beagle dogs.

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Determination of florfenicol residues in broiler meat and liver samples using RP‐HPLC with UV–visible detection

et al. 2015

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Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae

Cited by 93 publications

References 11 publications

Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs

Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs

Determination of florfenicol residues in broiler meat and liver samples using RP‐HPLC with UV–visible detection

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