Pharmacokinetics of doxycycline in tilapia (<i><scp>O</scp>reochromis aureus</i> × <i><scp>O</scp>reochromis niloticus</i>) after intravenous and oral administration

Yang, Fan; Li, Z. L.; Qi, Shihua; Zeng, Zhenling

doi:10.1111/jvp.12095

Cited by 29 publications

(32 citation statements)

References 41 publications

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“…In the present study, all fish were fasted overnight and fed feed 12 hr after oral administration, which might contribute to the higher bioavailability in crucian carps. Lower oral bioavailability was also reported for doxycycline in tilapia (23.41%; (Yang et al, 2014)). However, all of them were lower than that estimated here.…”

Section: Discussionmentioning

confidence: 83%

“…However, all of them were lower than that estimated here. Lower oral bioavailability was also reported for doxycycline in tilapia (23.41%; (Yang et al, 2014)).…”

Section: Discussionmentioning

confidence: 83%

“…The previous reports for other tetracyclines in fish species have indicated the tremendous variability among different tetracyclines (Li et al, 2015;Yang, Li, Shan, & Zeng, 2014;Zhang & Li, 2007). The previous reports for other tetracyclines in fish species have indicated the tremendous variability among different tetracyclines (Li et al, 2015;Yang, Li, Shan, & Zeng, 2014;Zhang & Li, 2007).…”

Section: Introductionmentioning

confidence: 97%

“…However, so far there have been no pharmacokinetics reports in any fish species. The previous reports for other tetracyclines in fish species have indicated the tremendous variability among different tetracyclines (Li et al, 2015;Yang, Li, Shan, & Zeng, 2014;Zhang & Li, 2007). Therefore, it is necessary to conduct the pharmacokinetics study of minocycline in fish species and to further examine the possibility of its application in carp production and its optimal dosage regimens.…”

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confidence: 99%

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Pharmacokinetics of minocycline in crucian carp (Carassius auratus ) after intravenous and oral administration

Yang

et al. 2018

Aquac Res

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The pharmacokinetic of minocycline was studied after a single intravenous as well as oral dose (5 mg/kg body weight) in crucian carp (Carassius auratus) reared in freshwater at 10°C. Plasma samples were randomly collected from six fish at each sampling time. Plasma concentrations were determined by high-performance liquid chromatography and further subjected to noncompartmental analysis. Initial concentration of minocycline just after intravenous administration was calculated as 7.320 lg/ml, while the other parameters after intravenous injection were determined as flows: apparent elimination rate constant (k z ) of 0.064 per hr, apparent elimination half-life (t 1=2kz ) of 10.82 hr, total body clearance (Cl) of 142.72 ml/hr/kg, volume of distribution (Vz) of 2,227.38 ml/kg and volume of distribution at steadystate (Vss) of 1,937.08 ml/kg. While after oral administration, the k z , t 1=2kz , mean absorption time (MAT), absorption half-life (t 1/2ka ) and bioavailability were determined as 0.059 per hr, 11.74, 5.55, 3.84 hr, and 81.98%, respectively, and the peak concentration was observed as 1.474 AE 0.362 lg/ml at 8 hr. It was shown that minocycline was slowly but relatively completely absorbed, extensively distributed, and slowly eliminated in crucian carp. Based on the ratios of AUC 0-24 hr /MIC90, a minocycline dosage of 5 mg/kg body weight administered intravenously or orally would be only effective to successfully treat crucian carp infected by bacterium with MIC values ≤0.25 lg/ml. K E Y W O R D S bioavailability, crucian carp, minocycline, oral administration, pharmacokinetic wileyonlinelibrary.com/journal/are Aquaculture Research. 2018;49:2782-2787.

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Section: Discussionmentioning

confidence: 83%

“…However, all of them were lower than that estimated here. Lower oral bioavailability was also reported for doxycycline in tilapia (23.41%; (Yang et al, 2014)).…”

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 97%

mentioning

confidence: 99%

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Pharmacokinetics of minocycline in crucian carp (Carassius auratus ) after intravenous and oral administration

Yang

et al. 2018

Aquac Res

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“…It has good pharmacokinetics properties, including high assimilation rate and wide distribution to different body tissues after oral treatment (Aronson 1980;Riond and Riviere 1988). DOX kinetic properties have been studied in channel catfish and Nile tilapia (Ai et al 2011;Ding et al 2009;Yang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic properties of single doxycycline dose orally administered in the African catfish (Clarias gariepinus)

Ibrahim¹,

Eleiwa²,

Galal³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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Pharmacokinetics Doxycycline dose HPLC African catfish (Clarias gariepinus) aquaculture has experienced widespread production and has lately gained considerable interest in Egypt. Doxycycline (DOX) is used to control certain common fish's bacterial diseases, such as Septicemia, Fin rot, Columnaris, and Tail Rot. Therefore, our experiment was conducted to assess the pharmacokinetic properties of single doxycycline dose (20 mg/kg BW) orally administered in the African catfish. DOX plasma levels were measured using HPLC with a limit of detection nearly 0.035 µg/ ml, and then were undergoing compartmental analysis; a onecompartment model was detected. The doubled-peak phenomenon was identified after oral administration and the 1 st peak concentration (C max1) and the 2 nd peak concentration (C max2) in plasma were 2.29±0.46 and 1.68±0.33µg/mL at 1 st and 8 th h respectively, the absorption half-life (t 1/2ka) was 0.045 h, the elimination half-life (t 1/2ke) was 5.81 h, systemic total body clearance (Cl) was 0.72 mL/h/kg, volume of distribution of the central compartment (V d /F) was 5.74±1.11 L. These findings suggested that DOX was to some extent rapidly absorbed, widely distributed, and slowly excreted; moreover, it could be subjected to enterohepatic recycling.

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Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

Altan,

Corum,

Durna Corum

et al. 2024

Veterinary Medicine & Sci

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ObjectiveDoxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss).MethodsPlasma samples were collected at specific time points and subsequently analysed by HPLC‐ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration.ResultsAfter IV administration, the elimination half‐life (t1/2ʎz), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady‐state and total body clearance of DO were 34.81 h, 723.82 h µg/mL, 1.24 L/kg and 0.03 L/kg/h, respectively. The t1/2λz of the DO was found to be 37.39 and 39.78 h after IM, and OR administration, respectively. The bioavailability was calculated 57.02% and 32.29%, respectively, after IM and OR administration. The MIC90 of DO against A. hydrophila and A. sobria was 4 µg/mL. The PK/PD integration showed that DO (20 mg/kg dose) for A. hydrophila and A. sobria with MIC90 ≤4 µg/mL achieved target AUC/MIC value after IM administration.ConclusionsThese results suggest that when rainbow trout was treated with 20 mg/kg IV and IM administered DO, therapeutically effective concentrations were reached in the control of infections caused by A. hydrophila and A. sobria.

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Pharmacokinetics of doxycycline in tilapia (Oreochromis aureus × Oreochromis niloticus) after intravenous and oral administration

Cited by 29 publications

References 41 publications

Pharmacokinetics of minocycline in crucian carp (Carassius auratus ) after intravenous and oral administration

Pharmacokinetics of minocycline in crucian carp (Carassius auratus ) after intravenous and oral administration

Pharmacokinetic properties of single doxycycline dose orally administered in the African catfish (Clarias gariepinus)

Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

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