Pharmacokinetics of doramectin in lactating dairy sheep and suckling lambs

Kinetics of Abamectin Disposition in Blood Plasma and Milk of Lactating Dairy Sheep and Suckling Lambs

“…The highest ABM concentrations detected in blood plasma and milk samples were 42.0 and 37.5 µg L −1 , respectively, found in the same animal on the first day post-treatment. Mean ABM c max in blood plasma was approximately 3-fold higher compared to ivermectin and 2-fold higher compared to doramectin as observed in our previous studies performed under the same conditions, including animal species and breed, physiological conditions, nutrition, mode of drug administration, sampling schedule, residue, and pharmacokinetic analysis. Henceforth, t max ABM concentrations gradually declined with time and fell below LOD for both ewes’ matrices from day 17 onward.…”

“…In ewes, mean excretion time for ABM concentration to fall below LOD was 22.5 and 23 days for blood plasma and milk, respectively. The presented results confirm the long withholding time of ABM in the organism, which was similar to ivermectin , but was considerably shorter than doramectin . The difference in withholding time is related to lipophilicity, as the octanol/water partition coefficient of doramectin is the highest of the three avermectins studied.…”

Review of methodology for the determination of macrocyclic lactone residues in biological matrices

“…It was estimated that 2.4% of the total dose of doramectin was excreted in milk. Cerkvenik-Flajs et al investigated the pharmacokinetics of doramectin residues in ewes' milk (sc 200 g/kg bw), finding that residue levels fell below the limit of detection of the method at 37 days post-treatment [73]. The maximum concentration of doramectin found in ewes' milk was 31 g/kg.…”

“…In some cases, cows have been known to calve as much as 30 days early. New sensitive methodologies are available that can detect ML residues in milk up to 37 days post-treatment, increasing the potential to detect ML abuse in lactating species [73].…”

Trace analysis of endectocides in milk by high performance liquid chromatography with fluorescence detection

“…In Slovenia, residues of endectocides have been followed during state monitoring of veterinary drug residues in food of animal origin since 1994, when analysis of IVM as the first such substance was introduced [19,20]. Since then, endectocide analysis has developed according to progressive addition of specific substances for research and monitoring purposes [21][22][23][24].…”