Pharmacokinetics of 2-phenyl-1,3-indandione in the rat after i.v. and oral administration

Abstract

The pharmacokinetics of the anticoagulant drug, 2-phenyl-1,3-indandione, after i.v and oral administration in the rat might be best described as a non-linear open two-compartment model with elimination fromthe peripheral compartment. The volume of the central compartment comprises the extracellular fluid.