Kinetics of bromadiolone, anticoagulant rodenticide, in the norway rat (Rattus norvegicus)

Nahas, K.

doi:10.1016/0031-6989(87)90011-7

Cited by 22 publications

(5 citation statements)

References 8 publications

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“…This plasma circulation is low, but also very transient, whereas the presence of the molecule persists for several weeks or even months in the liver. Thus, previous studies show that after a single or repeated administration, bromadiolone becomes undetectable in plasma about 7 days after administration [38,53] . In our study, it becomes undetectable in plasma between 14 and 30 days after initial administration.…”

Section: While Detection Of Ars In Plasma Has Been Suggested As a Pos...mentioning

confidence: 84%

“…Faecal residues consist of either direct eliminated non absorbed compound by the gastrointestinal tract or excreted unchanged unbound compounds. Biliary excretion and enterohepatic circulation also contribute to the continued elimination in faeces over a long period [36,53,57] . If the faecal matrix appears to be more relevant for monitoring the exposure of domestic and wild animals, is it possible to extrapolate the information from the analysis of this matrix to liver contamination?…”

Section: While Detection Of Ars In Plasma Has Been Suggested As a Pos...mentioning

confidence: 99%

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Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

Rached

Mahjoub

Fafournoux

et al. 2023

Environmental Toxicology and Pharmacology

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Section: While Detection Of Ars In Plasma Has Been Suggested As a Pos...mentioning

confidence: 84%

Section: While Detection Of Ars In Plasma Has Been Suggested As a Pos...mentioning

confidence: 99%

Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

Rached

Mahjoub

Fafournoux

et al. 2023

Environmental Toxicology and Pharmacology

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“…These specific pathways for each stereoisomer could be the source of their different half-lives (95). If a part of some FGAR can be eliminated through urine (96,97); the majority of AR are mainly or exclusively eliminated through feces (86,87,98,99).…”

Section: General Pharmacokinetic Properties Of Anticoagulant Rodenticmentioning

confidence: 99%

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

et al. 2020

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The widespread use of pesticides to control agricultural pests is a hot topic on the public scene of environmental health. Selective pest control for minimum environmental impact is a major goal of the environmental toxicology field, notably to avoid unintended poisoning in different organisms. Anticoagulant rodenticides cause abnormal blood coagulation process; they have been widely used to control rodents, allowing inadvertent primary and secondary exposure in domestic animals and non-target predatory wildlife species through direct ingestion of rodenticide-containing bait or by consumption of poisoned prey. To report toxic effect, the most common approach is the measurement of liver or plasma residues of anticoagulant rodenticides in dead or intoxicated animals showing clinical symptoms. However, one major challenge is that literature currently lacks a hepatic or plasma concentration threshold value for the differentiation of exposure from toxicity. Regarding the variation in pharmacology properties of anticoagulant rodenticides inter- and intra-species, the dose-response relationship must be defined for each species to prejudge the relative risk of poisoning. Beyond that, biomarkers are a key solution widely used for ecological risk assessment of contaminants. Since anticoagulant rodenticides (AR) have toxic effects at the biochemical level, biomarkers can serve as indicators of toxic exposure. In this sense, toxicological knowledge of anticoagulant rodenticides within organisms is an important tool for defining sensitive, specific, and suitable biomarkers. In this review, we provide an overview of the toxicodynamic and toxicokinetic parameters of anticoagulant rodenticides in different animal species. We examine different types of biomarkers used to characterize and differentiate the exposure and toxic effects of anticoagulant rodenticide, showing the strengths and weaknesses of the assays. Finally, we describe possible new biomarkers and highlight their capabilities.

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“…After oral administration to rats, bromadiolone was eliminated relatively quickly from blood, resulting in high concentrations in liver tissues (Kamil 1987). Elimination of radiolabelled bromadiolone from rat liver is reported to be biphasic, consisting of a rapid initial phase lasting from 2 to 8 days after dosing and a slower terminal phase (Anonymous 2010).…”

Section: Bromadiolonementioning

confidence: 99%

Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms

Horak¹,

Fisher

Hopkins

2017

Emerging Topics in Ecotoxicology

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Kinetics of bromadiolone, anticoagulant rodenticide, in the norway rat (Rattus norvegicus)

Cited by 22 publications

References 8 publications

Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

Biomarkers Potency to Monitor Non-target Fauna Poisoning by Anticoagulant Rodenticides

Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms

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