Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens

Anadón, Arturo; Martínez-Larrañaga, María-Rosa; Iturbe, J; Díaz, María Jesús Villamide; Frejo, María Teresa; Martínez, Marta

doi:10.1053/rvsc.2001.0494

Cited by 70 publications

(75 citation statements)

References 32 publications

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“…The systemic bioavailability of marbofloxacin in normal broiler chickens was (73.57 ± 1.90%). it was nearly similar to that of enrofloxacin (68.11%) in Muscovy ducks (Intorre et al, 1997), ciprofloxacin (69.12± 6.95%) in broiler chickens (Anadon et al, 2001) and levofloxacin (70.09 ± 9.8%) in broiler chickens (Kalaiselvi et al, 2006). On the other hand, it was higher than values recorded for marbofloxacin (56.82%) in broiler chickens (Anadon et al, 2002).…”

Section: Discussionsupporting

confidence: 71%

Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E.coli infected broiler chicken

Elkomy¹,

Attia²,

Latif³

et al. 2016

IJPT

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The pharmacokinetics of marbofloxacin was studied following a single intravenous, oral administration in normal broiler chickens and repeated oral administrations in normal and experimentally E.coli infected broiler chickens. The pharmacokinetic parameters following a single intravenous injection of 2 mg/kg b.wt., revealed that marbofloxacin obeyed a two compartments open model, distribution half-life (t 0.5(α) ) was 0.25±0.02 h, volume of distribution (V dss ) was 0.76±0.08 L/kg, elimination half-life (t 0 . 5(β) ) was 5.43±0.87 h and total body clearance (CL tot ) was 0.09±0.002 l/kg/h. Following a single oral administration, marbofloxacin was rapidly and efficiently absorbed through gastrointestinal tract of chickens as the absorption half-life (t 0.5 (ab) : 0.62±0.02 h). Maximum serum concentration (C max ) was 1.15±0.01 μg/ml, reached its maximum time (t max ) at 2.53±0.04 h, elimination half-life (t 0.5 (el) ) was 7.36±0.20 h indicating the tendency of chickens to eliminate marbofloxacin in slow rate. Oral bioavailability was 73.57± 1.90 % indicating good absorption of marbofloxacin after oral administration. Serum concentrations of marbofloxacin following repeated oral administration of 2 mg/kg b.wt. once daily for five consecutive days, peaked 2 hours after each oral dose with lower significant values recorded in experimentally infected broiler chickens than in normal ones. Tissues residues of marbofloxacin in slaughtered normal chickens was highly in those tissues lung, liver, and kidneys in chickens and the chicken must not be slaughtered before 3 days of stopping of drug administration. It was concluded that the in-vitro protein binding was 12.33±0.82%.

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Section: Discussionsupporting

confidence: 71%

Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E.coli infected broiler chicken

Elkomy¹,

Attia²,

Latif³

et al. 2016

IJPT

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“…For most enrofloxacin-susceptible isolates, it is possible to achieve concentrations of enrofloxacin greater than their MPCs at the infection site. However, MPC values of mutant strains exceed the C max of enrofloxacin (1.88-2.44 µg/ml) in chickens [1,10,12]. APEC strains possessing at least 1 mutation in QRDRs account for 57.4% of APEC strains [16].…”

Section: Discussionmentioning

confidence: 98%

Relationships between Mutant Prevention Concentrations and Mutation Frequencies against Enrofloxacin for Avian Pathogenic <i>Escherichia coli</i> Isolates

Ozawa

Asai

2013

The Journal of Veterinary Medical Science

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ABSTRACT. Clinical efficacies of mutant prevention concentration (MPC) and mutant selection window (MSW) hypotheses have been evaluated for human clinical isolates. We tested the MSW hypothesis by evaluating the relationships between MPCs and mutation frequencies against enrofloxacin for avian pathogenic Escherichia coli (APEC) isolates. Mutation frequencies of strains with MPC:MIC ratios of 8 to 16 were significantly higher than those of strains with an MPC:MIC ratio of 4. Mutation frequencies and MPCs of serogroup O2 strains were lower than those of the other strains; these results may correlate with the absence of fluoroquinolone-resistant O2 strains. Our results support the MSW hypothesis that the range of the MSW is involved in selection of resistant mutants.

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“…In order to search fluoroquinolone residues in edible chicken tissues, Anadón et al (2001) treated broilers with oral doses of 8 mg ciprofloxacin/kg daily for three days, and then analyzed the liver, kidneys, muscles, and skin+fat. The authors concluded that a withdrawal period of 10 days was sufficient to bring the levels of ciprofloxacin and its metabolites below the MRLDVs established by the EU for enrofloxacin.…”

Section: Studies On Fluoroquinolone Residues In Poultry Productsmentioning

confidence: 99%

Fluoroquinolones in industrial poultry production, bacterial resistance and food residues:a review

Gouvêa

Santos

Aquino

et al. 2015

Rev. Bras. Cienc. Avic.

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Pharmacokinetics and residues of ciprofloxacin and its metabolites in broiler chickens

Cited by 70 publications

References 32 publications

Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E.coli infected broiler chicken

Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E.coli infected broiler chicken

Relationships between Mutant Prevention Concentrations and Mutation Frequencies against Enrofloxacin for Avian Pathogenic <i>Escherichia coli</i> Isolates

Fluoroquinolones in industrial poultry production, bacterial resistance and food residues:a review

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