Pharmacokinetic Basis for Oral Perioperative Prophylaxis with Ofloxacin in General Surgery

Abstract

Tissue and serum concentrations and the antibacterial spectrum of orally administered ofloxacin suggest effective protection against perioperative infection. Pharmacokinetic data confirm that oral ofloxacin may be used effectively as single-dose perioperative antibiotic prophylaxis. Since there are no clinical data comparing oral and intravenous singLe-dose prophylaxis, a prospective randomized clinical trial should be performed.

Efficacy of oral ofloxacin for single-dose perioperative prophylaxis in general surgery – a controlled randomized clinical study

“…This shows that the regimen of preoperative bowel preparation, fasting, and premedication does not reduce intestinal resorption and bioavailability of ofloxacin [21].…”

“…Quinolones are characterized by a high intestinal resorption and high bioavailability after enteral administration. Bioavailability is not altered by peroperative fasting bowel preparation and anesthesiologic premedication [21]. Quinolones are effective against gram-negative enteral and gram-positive epidermal flora, thus meeting the requirements for oral antibiotic prophylaxis.…”

A Rapid Assay of Mezlocillin Sodium by Flow-Injection Chemiluminescence Detection

“…It treats many kinds of infections including those of the skin, blood, central nervous system, respiratory tract, sinuses and urinary tract. It also treats certain infections in women (gynecological infections) [1][2][3][4][5][6][7] . High-performance liquid chromatographic (HPLC) methods have been developed for the determination of mezlocillin.…”

Perioperative Antibiotic Prophylaxis - Still Room for Improvement

“…If we invest some time and effort in this task, the rewards will be tangible for individual patients, the hospital and public health. Only after we succeed in this basic task, will we have the luxury to refine prophylaxis by studying options for further cost savings or improvement of convenience through the use of new modalities such as oral administration of antibiotics [4]. …”