Pharmacognostic and pharmacological evaluation ofEulaliopsis binataplant extracts by measuringin vitro/in vivosafety profile and anti-microbial potential

Sharma, Arun K; Sharma, Arun Kumar; Rajput, Satyendra K.; Pal, Mahesh; Dhiman, Neerupma

doi:10.1039/c8tx00017d

Cited by 8 publications

(3 citation statements)

References 24 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suspension of prepared nanoparticles was prepared and tested against standard (STD) solution of amoxicillin 10 µg/ml and evaluated against CNPs suspension 10, 120, and 30 µg/ml. Zone of inhibition was noted and compared against STD at the 12th hr of incubation 37 ℃ in Luria broth medium [21].…”

Section: Study Of Antibacterial Propertymentioning

confidence: 99%

Therapeutic Evaluation of Chemically Synthesized Copper Nanoparticles to Promote Full-Thickness Excisional Wound Healing

Kumar

Pandit²,

Nagaich

2020

Int J App Pharm

View full text Add to dashboard Cite

Objective: The purpose of this research was, synthesis of copper nanoparticles using environment friendly cementation method and evaluate their wound healing property on full-thickness excisional wound. Methods: Present study reports the synthesis of CNPs by single-step cementation method. Evaluation of CNPs was endorsed by morphological and chemical properties. Furthermore, CNPs was evaluated for its antibacterial potential and invitro hemocompatibility. Additionally, pharmacological evaluation of CNPs was assessed against excisional wound. Results: Characterization of final product indicate, particle size of CNPs were ranging from 100-150 nm. CNPs showed significant antibacterial activity (A= 2.1±0.1 mm, B =2.1±0.1 mm, C = 1.9±0.2 mm, at 10µg/ml), along with superior hemocompatibility (RBC cell survival 97±1 %). Further CNPs formulation shows increased level of anti-inflammatory cytokinin’s (IL-10, 42.7%) as compared to standard (STD), vehicle control, and normal control groups, attributed to accelerated wound healing (p<0.05 vs STD). Conclusion: The consequences the present investigation endorse the accelerated wound healing potential of CNPs with its anti-inflammatory potential.

show abstract

Section: Study Of Antibacterial Propertymentioning

confidence: 99%

Therapeutic Evaluation of Chemically Synthesized Copper Nanoparticles to Promote Full-Thickness Excisional Wound Healing

Kumar

Pandit²,

Nagaich

2020

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…The synthesized Schiff bases were screened for antibacterial activity. 20 . Bacterial strains were cultivated and maintained by using Luria Bertani agar media (Himedia laboratory, India).…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis, Characterization, and Antibacterial Activity of Schiff Bases Derived From Thiosemicarbazide, 2-Acetyl Thiophene and Thiophene-2 Aldehyde

Mohan¹,

Kumar²,

Kumari³

2018

Int Res J Pharm

Self Cite

View full text Add to dashboard Cite

Two Schiff bases 2-acetylthiophene thiosemicarbazone (L1) and thiophene-2-aldehyde thiosemicarbazone (L2) were prepared in excellent yield via the condensation of 2-acetyl thiophene/ thiophene-2-aldehyde and thiosemicarbazide. The lead (II) and nickel (II) metal complexes of the Schiff base ligands ([Pb(L1)2]Cl2 and [Ni(L1)2]Cl2 were also prepared. The ligands and complexes were tested against gram-negative [E. Coli (MTCC No: 452)] and gram-positive bacterial strains Bacillus sp [(MTCC No: 297)] by using Kirby-Bauer's method. The compound ([Pb(L1)2]Cl2 was found out to be more active against both bacterial strain (E. coli & Bacillus sp) having zone of inhibition12.45 ± 1.2 and 11.27 ± 1.1 mm respectively.

show abstract

“…Among these components, polysaccharides are the main fraction in terms of dry matter and important reported therapeutic properties, such as antitumoral, anti-inflammatory, and immunosuppressive activities (17). Regarding antibacterial activity of Aloe vera gel, it has been mainly attributed to phenolic compounds, such as anthraquinones (19)(20)(21). However, some studies have also proposed that such antibacterial activity may result from a synergistic interaction of several of its compounds (6,17,18).…”

Section: Introductionmentioning

confidence: 99%

Efficacy Prediction of Four Pharmaceutical Formulations for Intramammary Administration Containing Aloe vera (L.) Burm. f. Combined With Ceftiofur or Cloxacillin in Lactating Cows as an Alternative Therapy to Treat Mastitis Caused by Staphylococcus aureus

et al. 2021

View full text Add to dashboard Cite

Synergy or additive effect between Aloe vera (L.) Burm.f. and beta-lactam (β-lactam) antibiotics has been reported against Staphylococcus aureus, one of the most important etiological agents of cow mastitis. The goal of the present study was to predict the efficacy of intramammary formulations containing the Aloe vera gel extract in the combination with cloxacillin or ceftiofur at low concentrations in lactating cows as an alternative therapy. Each quarter of 20 healthy Holstein Friesian lactating cows were treated with a single dose of one of the following formulations, corresponding to one of these treatment groups: A1, A2, A3, and A4. A1 and A2 contained cloxacillin at 0.25 and 0.5 mg/ml, whereas A3 and A4 contained ceftiofur 0.25 and 0.5 mg/ml, respectively. In addition, all formulations contained 600 mg/ml of an alcoholic extract of Aloe vera. Milk samples were taken at predefined time points. Antibiotics and aloin (active compound of Aloe vera) concentrations were assessed by liquid chromatography mass spectrometry system (LC-MS/MS). Pharmacokinetic profiles were obtained, and the efficacy index, the fraction of dosing interval in which the antimicrobial concentration remains above the minimum inhibitory concentrations (MICs) (T > MIC) for each formulation, was calculated considering MIC values against Staphylococcus aureus ATCC 29213 as obtained for the combination Aloe vera + antibiotic and aloin concentration in the extract. Mammary gland safety assessment was performed for each combination. Values of the main efficacy index for this study, T > MIC (h) for Aloe vera were 23.29, 10.50, 27.50, and 13.89, whereas for cloxacillin or ceftiofur were 19.20, 10.9, 19.74, and 15.63, for A1, A2, A3, and A4, respectively. Only A1 and A3 reached aloin and antibiotic recommended values as predictors of clinical efficacy for cloxacillin, ceftiofur, and aloin (50, 70, and 60%, respectively), assuming a dose interval of 24 h. The efficacy index values obtained suggest that A1 and A3 might be an effective therapy to treat bovine mastitis caused by S. aureus after a single dose. Nevertheless, further trials in S. aureus mastitis clinical cases are mandatory to confirm the efficacy of Aloe vera formulations.

show abstract

Pharmacognostic and pharmacological evaluation ofEulaliopsis binataplant extracts by measuringin vitro/in vivosafety profile and anti-microbial potential

Cited by 8 publications

References 24 publications

Therapeutic Evaluation of Chemically Synthesized Copper Nanoparticles to Promote Full-Thickness Excisional Wound Healing

Therapeutic Evaluation of Chemically Synthesized Copper Nanoparticles to Promote Full-Thickness Excisional Wound Healing

Synthesis, Characterization, and Antibacterial Activity of Schiff Bases Derived From Thiosemicarbazide, 2-Acetyl Thiophene and Thiophene-2 Aldehyde

Efficacy Prediction of Four Pharmaceutical Formulations for Intramammary Administration Containing Aloe vera (L.) Burm. f. Combined With Ceftiofur or Cloxacillin in Lactating Cows as an Alternative Therapy to Treat Mastitis Caused by Staphylococcus aureus

Contact Info

Product

Resources

About