Pharmaceutically Used Plasticizers

Snejdrova, Eva; Dittrich, Milan

doi:10.5772/39190

Cited by 41 publications

(35 citation statements)

References 52 publications

(46 reference statements)

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“…With the aim of making the FDA approval process quicker, plasticizers that were already deemed safe were chosen for the CAP-Pluronic films. Both triethyl citrate and tributyl citrate are common plasticizers used in pharmaceutical and biomedical devices ([20, 27–29]. The United States Pharmacoepia deems both TEC and TBC appropriate to be used in pharmaceutical dosage forms [29].…”

Section: Discussionmentioning

confidence: 99%

“…Both triethyl citrate and tributyl citrate are common plasticizers used in pharmaceutical and biomedical devices ([20, 27–29]. The United States Pharmacoepia deems both TEC and TBC appropriate to be used in pharmaceutical dosage forms [29]. They are used in gelatin capsules, enteric coatings on pills, and transdermal drug delivery patches [27, 28, 30].…”

Section: Discussionmentioning

confidence: 99%

“…Plasticizers with a lower molecular weight cause more flexibility in the material they are incorporated into because they have a higher mobility and allow polymer chains to more easily slide across one another [30]. With more lubricating plasticizer added to the films, a greater number of molecules were present between the polymer chains, which thereby increased the molecular separation and decreased the packing order of CAP and Pluronic F-127 [29]. Because of this, for the same weight percent of plasticizer added, the TEC had more of an impact on the mechanical properties of the CAP-Pluronic F-127 films.…”

Section: Discussionmentioning

confidence: 99%

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The effect of plasticizers on the erosion and mechanical properties of polymeric films

et al. 2013

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Cellulose acetate phthalate (CAP) and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate (TEC) or tributyl citrate (TBC) was combined with CAP and Pluronic F-127 at 0, 10, or 20 wt%. Mechanical analysis was performed on the films as they were prepared and following a 2 hour incubation in phosphate-buffered saline. Tensile tests showed that higher plasticizer content increased the % elongation but decreased the elastic modulus (E) and ultimate tensile strength (UTS). The effect TEC had on the % elongation was twice as much than that of TBC. After incubation, % elongation, E, and UTS all increased because plasticizer leached out of the films. MicroCT and SEM were performed on the samples both before and after incubation to determine how erosion and leaching of plasticizer affected the interior and exterior structure of the films. Porosity increased as plasticizer content increased, however, plasticizer content did not have a significant effect on the rate of erosion. The mechanical properties of CAP-Pluronic films can be adjusted by the type and amount of plasticizer added to the system and therefore can be tailored for different drug delivery applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of plasticizers on the erosion and mechanical properties of polymeric films

et al. 2013

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“…A substance that mixed to a polymer reduces its Tg is generally called plasticizer while an antiplasticizer is a substance that provokes Tg increase [13,14]. Pharmaceutically relevant polymers may need addition of plasticizers to facilitate the manufacturing process or to obtain the desired characteristics [15,16]. However, in some cases, the plasticizing effect may be undesired [17,18].…”

Section: Introductionmentioning

confidence: 98%

β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing

Albertini

Iraci

Schoubben

et al. 2015

Journal of Drug Delivery Science and Technology

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“…Burst release occur if plasticizer leached out of the polymer results in pore formation. Subsequent release stage of drug is based on diffusion through the dense polymer phase [28][29] …”

Section: Drug Release Enhanced By Plasticizersmentioning

confidence: 99%

A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

Dave

Mishra

2017

Curr. Res. Pharm. Sci.

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Bioadhesive drug delivery system has gained sufficient attention of researchers not only due to their enormous advantages but also feasibility of formulation and patient compliance. In this review an effort was made to describe aspects of bioadhesive films, their preparation methods, polymer used in the formulation of this type of drug delivery system, different mechanism of how plasticizer work in drug delivery films and different evaluation parameters of this type of formulation so that this can be further studied and formulated with wide spectrum drug by checking suitability of the formulation with the active pharmaceutical ingredient.

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Pharmaceutically Used Plasticizers

Cited by 41 publications

References 52 publications

The effect of plasticizers on the erosion and mechanical properties of polymeric films

The effect of plasticizers on the erosion and mechanical properties of polymeric films

β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing

A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

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