Bioadhesive drug delivery system has gained sufficient attention of researchers not only due to their enormous advantages but also feasibility of formulation and patient compliance. In this review an effort was made to describe aspects of bioadhesive films, their preparation methods, polymer used in the formulation of this type of drug delivery system, different mechanism of how plasticizer work in drug delivery films and different evaluation parameters of this type of formulation so that this can be further studied and formulated with wide spectrum drug by checking suitability of the formulation with the active pharmaceutical ingredient.
Buccal films show rapid dissolution along with it also used to avoid first pass metabolism of the drug entrapped in the buccal film formulation because they get absorbed through buccal mucosa .The aim of present investigation was to explore the use of honey a plasticizers, compared with PEG400 as plasticizer. Film of Fentanyl Citrate a narcotic opoid analgesic for cancer breakthrough pain is formulated by solvent casting method using HPMC E 15 as a film forming agent, Honey and PEG400 as plasticizers and Sodium Starch Glycolate as superdisintigrant. All the formulations were evaluated on the basis of Tensile strength, %Elongation, in-vitro drug release and folding endurance. Through optimization F3 and F6 proved to be best formulation through which formulation with PEG400 proved better than with honey. But honey as plasticizers gives satisfactory result and can be used further for formulating film with natural plasticizer.
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