A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

Dave, Viny; Mishra, Ashwani Kumar

doi:10.24092/crps.2017.070301

Cited by 2 publications

(8 citation statements)

References 5 publications

(6 reference statements)

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“…From any class of pharmacology drugs, any drug can be used for buccal administration but it should be compatible with buccal mucosa [27,28]. API should not show irritation as they can lead to mucosal layer damage in the buccal cavity.…”

Section: Apimentioning

confidence: 99%

“…Plasticizers are used to reduce the fragility of mucoadhesive buccal films as well as for better flexibility and strength of the film. Plasticizers can be incorporated in the film from concentration 0-20% w/w of the dry polymer weight [14,27]. The selection of plasticizers depends on properties of drugs and mucoadhesive polymer used [13].…”

Section: Plasticizersmentioning

confidence: 99%

“…The selection of plasticizers depends on properties of drugs and mucoadhesive polymer used [13]. The action of plasticizer is to avoid the polymer-polymer interaction as it goes in between every individual polymer strand [27,54]. This helps to overcome the problem of polymer deformation.…”

Section: Plasticizersmentioning

confidence: 99%

“…This helps to overcome the problem of polymer deformation. Plasticizer also affects the release of the drug from the film [27]. Examples of plasticizers used in the buccal film include glycerol, low molecular weight polyethylene glycol, phthalate derivatives such as dimethyl and diethyl phthalate, and citrate derivatives such as tributyl, triethyl, acetyl citrate, triacetin, and castor oil [27,55].…”

Section: Plasticizersmentioning

confidence: 99%

“…Mostly acids are used as saliva stimulators in the formulation as they trigger the immediate production of excess saliva in the buccal cavity [20]. Examples of saliva stimulants are citric acid, maleic acid, lactic acid, Vitamin C (ascorbic acid), and tartaric acid [12,25,27]. They can be used in buccal film alone or in combination from concentration 2% to 6% w/w dry weight of the film [12,25].…”

Section: Saliva Stimulating Agent (Saliva Stimulator)mentioning

confidence: 99%

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Mucoadhesive Buccal Films: A Novel Approach for the Delivery of Anti-Hypertensive Drugs

Yelave¹,

Bhagwat²

2021

Asian J Pharm Clin Res

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The buccal drug delivery system is a prominent route of administration for drug delivery through the buccal mucosa. It is rich in blood supply with more surface area for rapid absorption as well as provides direct entry of drugs from the site of application into the systemic circulation through the jugular vein. Buccal drug delivery systems consist of various approaches such as lozenges, wafers, gels, microparticles, patches or films from which mucoadhesive buccal film is an attractive dosage form in terms of flexibility and high systemic bioavailability. Since most of the antihypertensive drugs show first-pass metabolism which leads to less oral bioavailability generally up to 20–50%. Thus, incorporation of antihypertensive drugs in mucoadhesive buccal films using mucoadhesive polymers can provide higher systemic bioavailability. The films can be formulated using various techniques such as solvent casting method and hot extrusion melt method. These films can be evaluated based on various characteristics to determine their efficacy and performance such as tensile strength, mucoadhesion residence time, and kinetic release data analysis. They have various advantages over conventional solid oral dosage forms, hence are preferable for the preparation of antihypertensive drug-loaded buccal films. Mucoadhesive buccal films of antihypertensive drugs can also provide controlled drug delivery with enhanced bioavailability.

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Section: Apimentioning

confidence: 99%

Section: Plasticizersmentioning

confidence: 99%

Section: Plasticizersmentioning

confidence: 99%

Section: Plasticizersmentioning

confidence: 99%

Section: Saliva Stimulating Agent (Saliva Stimulator)mentioning

confidence: 99%

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Mucoadhesive Buccal Films: A Novel Approach for the Delivery of Anti-Hypertensive Drugs

Yelave¹,

Bhagwat²

2021

Asian J Pharm Clin Res

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Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

Haju¹,

Yadav²,

BAIG³

et al. 2021

Asian J Pharm Clin Res

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Buccal drug delivery especially refers to the delivery of drugs through the buccal mucosal membrane lining of the oral cavity. For geriatric and pediatric patients who undergo difficulties in swallowing conventional oral solid dosage forms, the buccal film is a better alternative. The buccal film is appropriate for the drugs which experience high first-pass metabolism and is used for enhancing bioavailability with reducing dosing frequency to mouth plasma peak levels, which thus limit side-effects and make it cost-effective. It enhances the efficacy of API in the oral cavity after the contact with less saliva as contrasted to tablets, without chewing and no need for water for administration. This review briefly describes the advantages and limitations of buccal film, an anatomical structure of oral mucosa, highlighting the mechanisms of drug permeation, formulation technologies, methodology in evaluating buccal film, and recent advances of the buccal film as a tool for drug delivery for various treatments.

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A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System

Cited by 2 publications

References 5 publications

Mucoadhesive Buccal Films: A Novel Approach for the Delivery of Anti-Hypertensive Drugs

Mucoadhesive Buccal Films: A Novel Approach for the Delivery of Anti-Hypertensive Drugs

Buccal Film: A Novel Approach for Oral Mucosal Drug Delivery System

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