Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Gong, Guowei; Zheng, Yuzhong; Yang, Yang; Sui, Yixuan; Wen, Zhen

doi:10.1155/2021/9952578

Cited by 23 publications

(18 citation statements)

References 85 publications

(117 reference statements)

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“…They are commonly found in plant species, and possess good bioactivities which have been applied in nutraceutical, medicinal, and cosmetic products [ 5 ]. Many different subclasses of flavonoids have been described from A. membranaceus including flavone, flavonol, flavanone, flavanonol, chalcone, aurone, isoflavone, and pterocarpan [ 6 ]. Phenolics, including flavonoids, have been judged as the marker for quality evaluation and standardization of A. membranaceus and its processed products [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

UHPLC–MS/MS Analysis on Flavonoids Composition in Astragalus membranaceus and Their Antioxidant Activity

et al. 2021

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Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity. To characterize the principal chemicals influenced by origin and provide more information about their antioxidant profile, the extracts of A. membranaceus roots from four origins were analysed by UHPLC-MS/MS. Thirty-four flavonoids, including thirteen methoxylated flavonoids, fifteen flavonoid glycosides and six flavonols, were identified. By principal component analysis, eighteen identified compounds were considered to be principal compounds. They could be used to differentiate A. membranaceus from Shanxi, Inner Mongolia, Heilongjiang and Gansu. The antioxidant activity was analysed by ORAC assay, DPPH radical scavenging activity assay and cell antioxidant activity assay. ‘Inner Mongolia’ extract showed the highest antioxidant activity. These results were helpful to understand how origin influenced the quality of A. membranaceus.

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Section: Introductionmentioning

confidence: 99%

UHPLC–MS/MS Analysis on Flavonoids Composition in Astragalus membranaceus and Their Antioxidant Activity

et al. 2021

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“…Isorhamnetin can repair the ocular surface injury in mice and downregulate the expression of inflammatory cytokines IL-1 β , IL-8, and TNF- α [ 25 ]. Calycosin isoflavones can inhibit the NF- κ B signaling pathway and play anti-inflammatory, antioxidative, and immunomodulatory roles [ 26 , 27 ]. The efficacy of QSSMS may be related to the synergic effects of active substances.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Verify the Mechanism of Qinshi Simiao San in Treating Chronic Prostatitis in the Rat Model

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Using network pharmacology and molecular docking, this study aimed to explore the active pharmaceutical ingredients (APIs) and molecular mechanism of Qinshi Simiao San (QSSMS) in the treatment of chronic prostatitis (CP) and verify our findings in the rat model. Methods. The APIs of QSSMS and the common targets of QSSMS and CP were screened from the TCMSP database. The STRING database and Cytoscape software were used to construct the network graph. The enriched GO and KEGG pathways were displayed by David software and R software. Molecular docking was performed to visualize key components and target genes. In addition, the rats model of CP was established to verify the molecular mechanism of QSSMS. Results. Network pharmacology showed that the APIs of QSSMS mainly included quercetin, kaempferol, formononetin, isorhamnetin, and calycosin. QSSMS alleviated CP mainly through the negative regulation of the apoptotic process, oxidation-reduction process, inflammatory response, and immune response. Molecular docking showed that the APIs could bind to the corresponding targets. QSSMS repaired the pathological damage of prostate tissue, upregulated the expression of oxidative stress scavenging enzymes CAT and SOD, and downregulated the peroxidative product MDA, inflammatory factors IL-1β, IL-6, TNF-α, COX-2, PGE2, and NGF, and immune factors IgG and SIgA. Conclusion. The APIs in QSSMS may inhibit inflammation in the rat CP model by regulating immune and oxidative stress.

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“…Verbasin has been verified to have antioxidant activity. Verbasin can inhibit the production of ROS by enhancing the activity of antioxidant enzymes, namely glutathione peroxidase, catalase and superoxide dismutase (SOD) [ 62 ].…”

Section: Biological Activities Of Armentioning

confidence: 99%

Advances in Chemical Composition, Extraction Techniques, Analytical Methods, and Biological Activity of Astragali Radix

et al. 2022

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Astragali Radix (AR) is one of the well-known traditional Chinese medicines with a long history of medical use and a wide range of clinical applications. AR contains a variety of chemical constituents which can be classified into the following categories: polysaccharides, saponins, flavonoids, amino acids, and trace elements. There are several techniques to extract these constituents, of which microwave-assisted, enzymatic, aqueous, ultrasonic and reflux extraction are the most used. Several methods such as spectroscopy, capillary electrophoresis and various chromatographic methods have been developed to identify and analyze AR. Meanwhile, this paper also summarizes the biological activities of AR, such as anti-inflammatory, antioxidant, antitumor and antiviral activities. It is expected to provide theoretical support for the better development and utilization of AR.

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Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Cited by 23 publications

References 85 publications

UHPLC–MS/MS Analysis on Flavonoids Composition in Astragalus membranaceus and Their Antioxidant Activity

UHPLC–MS/MS Analysis on Flavonoids Composition in Astragalus membranaceus and Their Antioxidant Activity

Network Pharmacology and Molecular Docking Verify the Mechanism of Qinshi Simiao San in Treating Chronic Prostatitis in the Rat Model

Advances in Chemical Composition, Extraction Techniques, Analytical Methods, and Biological Activity of Astragali Radix

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