Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review

Zhu, Hongkang; Liu, Chang; Qian, He

doi:10.3390/plants11152004

Cited by 7 publications

(3 citation statements)

References 90 publications

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“…At high altitudes, more significant anti-fatigue-related pharmacological effects were shown in medicinal plants through natural selection and habitat coevolution ( Zhu et al, 2022 ). For the plants Horedum vulgare, Triticum aestivum and Pisum sativum , with increasing altitude, the respiration of these plants would be enhanced, which might be advantageous to the higher metabolic activities of these plants ( Kumar et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Fatty acid metabolites of Dendrobium nobile were positively correlated with representative endophytic fungi at altitude

Zhao¹,

Qi²,

Tan³

et al. 2023

Front. Microbiol.

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IntroductionAltitude, as a comprehensive ecological factor, regulates the growth and development of plants and microbial distribution. Dendrobium nobile (D. nobile) planted in habitats at different elevations in Chishui city, also shows metabolic differences and endophytes diversity. What is the triangular relationship between altitude, endophytes, and metabolites?MethodsIn this study, the diversity and species of endophytic fungi were tested by ITS sequencing and metabolic differences in plants were tested by UPLC–ESI–MS/MS. Elevation regulated the colonization of plant endophytic fungal species and fatty acid metabolites in D. nobile.ResultsThe results indicate that and high altitude was better for the accumulation of fatty acid metabolites. Therefore, the high-altitude characteristic endophytic floras were screened, and the correlation with fatty acid metabolites of plants was built. The colonization of T. rubrigenum, P. Incertae sedis unclassified, Phoma. cf. nebulosa JZG 2008 and Basidiomycota unclassified showed a significantly positive correlation with fatty acid metabolites, especially 18-carbon-chain fatty acids, such as (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid, 3,7,11,15-tetramethyl-12-oxohexadeca-2,4-dienoic acid and Octadec-9-en-12-ynoic acid. What is more fascinating is these fatty acids are the essential substrates of plant hormones.DiscussionConsequently, it was speculated that the D. nobile- colonizing endophytic fungi stimulated or upregulated the synthesis of fatty acid metabolites and even some plant hormones, thus affecting the metabolism and development of D. nobile.

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Section: Discussionmentioning

confidence: 99%

Fatty acid metabolites of Dendrobium nobile were positively correlated with representative endophytic fungi at altitude

Zhao¹,

Qi²,

Tan³

et al. 2023

Front. Microbiol.

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“…Because its growth environment is harsh, it has strong vitality and special adaptability. Modern pharmacological studies have revealed that RRL has a variety of biological activities, such as antioxidant [2], antifatigue [3], anti-inflammatory [4,5], antidepressant [6] and antitumor [7] effects.…”

Section: Botanical Origin and Molecular Structure Of Rosavinmentioning

confidence: 99%

Rosavin: Research Advances in Extraction and Synthesis, Pharmacological Activities and Therapeutic Effects on Diseases of the Characteristic Active Ingredients of Rhodiola rosea L.

Wang,

Feng,

Zheng

et al. 2023

Molecules

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Rhodiola rosea L. (RRL) is a popular plant in traditional medicine, and Rosavin, a characteristic ingredient of RRL, is considered one of the most important active ingredients in it. In recent years, with deepening research on its pharmacological actions, the clinical application value and demand for Rosavin have been steadily increasing. Various routes for the extraction and all-chemical or biological synthesis of Rosavin have been gradually developed for the large-scale production and broad application of Rosavin. Pharmacological studies have demonstrated that Rosavin has a variety of biological activities, including antioxidant, lipid-lowering, analgesic, antiradiation, antitumor and immunomodulation effects. Rosavin showed significant therapeutic effects on a range of chronic diseases, including neurological, digestive, respiratory and bone-related disorders during in vitro and vivo experiments, demonstrating the great potential of Rosavin as a therapeutic drug for diseases. This paper gives a comprehensive and insightful overview of Rosavin, focusing on its extraction and synthesis, pharmacological activities, progress in disease-treatment research and formulation studies, providing a reference for the production and preparation, further clinical research and applications of Rosavin in the future.

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“…Most Rhodiola species grow on slopes or rock outcrops of limestones and granites in the cold regions of the Northern Hemisphere (Fu and Ohba, 2001). Rhodiola plants have evolved several specific morphological traits to facilitate its radiation in high-altitude regions (Zhu et al, 2022), characterized by high cold, hypoxia, strong UV radiation, and strong winds with sand. For example, some species exhibit dimorphism, elongated rhizomes, marcescent old flower stems, or scaly cauline leaves (Ren et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Comparative chloroplast genomes: insights into the identification and phylogeny of rapid radiation genus Rhodiola

Liu,

Zang,

Tian

et al. 2024

Front. Plant Sci.

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Rhodiola L. is a genus exhibiting rapid radiation and represents a typical case for studying plastid gene adaptation in species that spread from high altitudes to low altitudes. In this study, 23 samples of 18 Rhodiola species were collected from the Qinghai-Tibetan Plateau and five scattered alpine areas, and the plastid genomes (plastomes) of these species were sequenced, annotated, and compared between high-altitude and widely distributed groups. The plastomes of Rhodiola were found to be highly conserved in terms of gene size, content, and order but highly variable in several lineage-specific features, such as codon usage bias, IR boundary shifting, and distinct repeat sequence structures binding to SSRs. Codon usage in the genes of photosystem II exhibited an obvious preference, reflecting significant environmental adaptation pressures. In this study, three repeat regions compounded with trinucleotide and mononucleotide repeats were found for the first time in R. forrestii, R. himalensis, and R. yunnanensis. High-variability regions such as ndhF, ycf1, trnH-psbA, and rpoC1-rpoB were screened, laying the foundation for the precise identification of these species. The phylogenetic analysis revealed the occurrence of cyto-nuclear discordance, likely originating from the frequent interspecific hybridization events observed within Rhodiola species during rapid radiation. Dioecious and hermaphrodite species can be broadly categorized into two subclades, probably they have different environmental adaptation strategies in response to climate change. In addition, the phylogenetic tree supported the monophyly of R. forrestii and R. yunnanensis, which compose R. Sect. Pseudorhodiola. In conclusion, plastome data enrich the genetic information available for the Rhodiola genus and may provide insight into species migration events during climate change.

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Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review

Cited by 7 publications

References 90 publications

Fatty acid metabolites of Dendrobium nobile were positively correlated with representative endophytic fungi at altitude

Fatty acid metabolites of Dendrobium nobile were positively correlated with representative endophytic fungi at altitude

Rosavin: Research Advances in Extraction and Synthesis, Pharmacological Activities and Therapeutic Effects on Diseases of the Characteristic Active Ingredients of Rhodiola rosea L.

Comparative chloroplast genomes: insights into the identification and phylogeny of rapid radiation genus Rhodiola

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