Pharmaceutical cocrystallization techniques. Advances and challenges

New Preparation Method Using Microwave, Kinetics, In Vitro Dissolution‐Diffusion, and Anti‐Inflammatory Study of Diclofenac‐ Proline Co–Crystal

“…Mechanochemical processes such as grinding, with or without solvents, is laborious in terms of maintaining the continuity due to particle size, surface property changes, and the electrostatic effect during the process . Other methods such as slow evaporation have disadvantages, including difficulty maintaining the co‐solubility of the parent materials in solution due to their inherent different polarities and dielectric constants, while the hot extrusion/melting method has a high risk of chemical instability due to heat exposure . Our previous study reported a novel co‐crystal from acid form of diclofenac (DA), with L‐proline (LP) as the co‐former.…”

Multicomponent crystals of anti-tuberculosis drugs: a mini-review

“…2). Of these y-nine (59), twenty-seven (27) display synthon type II. Synthon types III, IV, V and VI are observed in ten (10), eleven (11), six (6) and twenty-four (24) structures respectively (Fig.…”

“…Solvent-free methods, on the other hand, include neat grinding, liquid assisted grinding, polymer assisted grinding, hot melt extrusion and matrix-assisted cocrystallization. 27 A more thorough discussion of these as well as other related techniques; their advantages and disadvantages can be found in the review by Rodrigues and co-workers. 27 Studies have shown that the solvent polarity plays a very important role in the self-assembly process during co-crystal formation in both solvent-based techniques as well as solventless techniques.…”

“…27 A more thorough discussion of these as well as other related techniques; their advantages and disadvantages can be found in the review by Rodrigues and co-workers. 27 Studies have shown that the solvent polarity plays a very important role in the self-assembly process during co-crystal formation in both solvent-based techniques as well as solventless techniques. 28,29 Co-crystals can be characterised using crystallographic techniques (single crystal X-ray diffraction and powder X-ray diffraction), spectroscopy (solid state nuclear magnetic resonance and NMR crystallography and, vibrational spectroscopy) and thermal analysis (differential scanning calorimetry, thermogravimetric analysis, hot stage microscopy).…”

Insight into Concept and Progress on Pharmaceutical Co-Crystals: An overview

“…12,13 Many of co-crystal strategies like solvent change techniques, 14 Solution co-crystallization, 15 thermal methods, 16 ultrasound assisted, 17 grinding methods 18 have been emerged. Previously, many of the case studies and reviews conducted in co-crystals reported, superiority of co-crystallization technology in comparison to other strategies, 19 improvements in manufacturing of drug dosage forms, 20 enhancements in drug properties by bottom-up approach, 21 pharmaceutical co-crystallization techniques, 22 translational development challenges, 23 impact of co-crystals on drug pharmacokinetics, 24 Co-crystallization of neutraceuticals, 25 Vibrational spectroscopic investigations on co-crystallization. 26 Improvement of physicochemical properties of co-crystallization have been well explored.…”