Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

Park, Heejun; Kim, Jeong-Soo; Kim, Sebin; Ha, Eun‐Sol; Kim, Min‐Soo; Hwang, Sung Joo

doi:10.3390/pharmaceutics13111928

Cited by 20 publications

(12 citation statements)

References 114 publications

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“…Supercritical fluid technology is a new type of nanocarrier preparation technology. A supercritical fluid is a special state of fluid formed when the material is above its critical temperature and critical pressure ( 70 ). Carbon dioxide, nitrogen, methane, water, and other common gases and liquids can be used as supercritical fluids, and in the industrial application of supercritical fluid technology, the most used is supercritical carbon dioxide (SC-CO 2 ).…”

Section: Construction Of Nano Slow-release Systemmentioning

confidence: 99%

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

et al. 2023

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At present, nano-carrier materials with antibacterial activity are of great significance. Due to the widespread resistance of many pathogenic microorganisms, it has seriously threatened human health. The natural antimicrobial substances extracted from fruits and vegetables can significantly improve their stability combined with nano-carrier materials. The resistance of pathogenic microorganisms will be substantially reduced, greatly enhancing the effect of active antimicrobial substances. Nanotechnology has excellent research prospects in the food industry, antibacterial preservation, food additives, food packaging, and other fields. This paper introduces nano-carrier materials and preparation techniques for loading and encapsulating active antibacterial substances in detail by constructing a nano-release system for active antibacterial substances. The antibacterial effect can be achieved by protecting them from adverse external conditions and destroying the membrane of pathogenic microorganisms. The mechanism of the slow release of the bacteriostatic active substance is also described. The mechanism of carrier loading and release is mainly through non-covalent forces between the bacteriostatic active substance and the carrier material, such as hydrogen bonding, π-π stacking, van der Waals forces, electrostatic interactions, etc., as well as the loading and adsorption of the bacteriostatic active substance by the chemical assembly. Finally, its wide application in food and medicine is introduced. It is hoped to provide a theoretical basis and technical support for the efficient utilization and product development of bacteriostatic active substances.

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Section: Construction Of Nano Slow-release Systemmentioning

confidence: 99%

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

et al. 2023

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“…In fact, process SFEE is mentioned as an important method for the production of micro/nanoparticles using SCF and has been proposed as an excellent way for the extraction of the organic solvent phase of emulsions. [124][125][126]. -Particle from gas-saturated solutions (PGSS) stands out among other supercritical strategies since it for the foremost part does not require organic solvents.…”

Section: Name Equation Of State Parametersmentioning

confidence: 99%

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Sodeifian

Usefi

2022

ChemBioEng Reviews

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Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC‐CO2 is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi‐empirical, and intelligence models to establish suitable correlations. SC‐CO2 is one of the most important materials used in SCFs to study solubility. Another application of SC‐CO2 is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC‐CO2. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC‐CO2 in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

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“…), nutraceuticals, pharmaceuticals from natural products and removal of pesticides from plant material [61,63]. It should be emphasized that life cycle assessments and technoeconomic calculations should be carried out when developing SFE processes, especially on an industrial scale [64].…”

Section: Application On Recovery Of Bioactive Compoundsmentioning

confidence: 99%

Lipid Extracts Obtained by Supercritical Fluid Extraction and Their Application in Meat Products

et al. 2022

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Supercritical fluid extraction (SFE) has been recognized as the green and clean technique without any negative impact on the environment. Although this technique has shown high selectivity towards lipophilic bioactive compounds, very few case studies on the application of these extracts in final products and different food matrices were observed. Considering the recent developments in food science and the increasing application of supercritical extracts in meat products in the last decade (2012–2022), the aim of this manuscript was to provide a systematic review of the lipid extracts and bioactives successfully obtained by supercritical fluid extraction and their application in meat products as antioxidant and/or antimicrobial agents. Lipophilic bioactives from natural resources were explained in the first step, which was followed by the fundamentals of supercritical fluid extraction and application on recovery of these bioactives. Finally, the application of natural extracts and bioactives obtained by this technique as functional additives in meat and meat products were thoroughly discussed in order to review the state-of-the-art techniques and set the challenges for further studies.

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Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation

Cited by 20 publications

References 114 publications

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Lipid Extracts Obtained by Supercritical Fluid Extraction and Their Application in Meat Products

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