Pharmaceutical applications of photothermal beam deflection

Hanh, Bui Duc; Faubel, W.; Heissler, S.; Wartewig, S.; Neubert, Reinhard H.H.

doi:10.1134/s1054660x06050094

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Probing was implemented with a continuous wave (cw) HeNe laser (Uniphase, CA), wavelength 632.8 nm, power 5 mW, and radius 60 lm. 3,[20][21][22] The probe beam offset x 0 could be varied from 100 lm up to 250 lm, and according to previous investigations 3, [20][21][22] the surface-to-probe distance (Fig. 1, inset) was set to x 0 ¼ 100 lm.…”

Section: Methodsmentioning

confidence: 99%

Photothermal Deflection Determination of Iron(II) with Ferrozine with Sorption Preconcentration on Silufol Plates

Khrycheva

Nedosekin²,

Проскурнин³

et al. 2008

Appl Spectrosc

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Photothermal deflection spectroscopy was applied to the selective detection of iron(II) chelate with ferrozine by its sorption preconcentration on Silufol plates. The linearity range was 1 x 10(-11) - 6 x 10(-8) mol cm(-2) of chelate at the plate surface, which corresponded to 1 x 10(-9) -4 x 10(-6) M of chelate in solution. The limits of detection and quantification are 8 x 10(-12) and 2.5 x 10(-11) mol cm(-2) at the plate from 15 microL of test solution (0.5 nM and 1.5 nM in solution, respectively), and the absolute detection limit is 8 fmol in the whole spot applied to a plate. Characteristics and features of photothermal deflection detection are discussed.

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Section: Methodsmentioning

confidence: 99%

Photothermal Deflection Determination of Iron(II) with Ferrozine with Sorption Preconcentration on Silufol Plates

Khrycheva

Nedosekin²,

Проскурнин³

et al. 2008

Appl Spectrosc

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“…700 m) were performed at three frequencies (17,24 and 31 Hz). This domain ranged over the boundary between the reservoir and the sample holder surface and is given in the x-and y-axes of the diagrams ( fig.…”

Section: Experimental Partmentioning

confidence: 99%

“…In order to keep the hoof membrane in a stable hydrated state the whole composition was arranged in a conditioned chamber that provided a constant relative humidity of approximately 100%. The PDS measurements were carried out with the photothermal device (Monobloc Phototherm Dr. Petry, Saarbrücken, Germany), which has previously been described [17,26] . A diode-pumped frequency-doubled Nd:YAG laser (wavelength: 532 nm; B&W TEK, Newark, Del., USA) was utilized as excitation source and a HeNe laser (633 nm) hereby served as a probe laser.…”

Section: Experimental Partmentioning

confidence: 99%

“…In the past few years, inexpensive and nondestructive variants of PDS have been successfully developed. Elsewhere it is reported on the potential use of the noninvasive PDS in pharmaceutical research exemplifying the investigation of lateral drug diffusion in an artificial membrane [17] . Furthermore, the in vivo determination of cosmetic ingredients in human skin is described [18] .…”

Section: Introductionmentioning

confidence: 99%

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Optical Methods for Measurements of Skin Penetration

Gotter¹,

Faubel²,

Neubert³

2008

Skin Pharmacol Physiol

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Fourier transform infrared photoacoustic (PAS), photothermal deflection (PDS) and Raman spectroscopy belong to the modern innovative noninvasive analytical tools that are beginning to be recognized as highly potential techniques for the noninvasive study of biological tissues and human skin under in vivo conditions. They can be applied to obtain information regarding the molecular composition of the skin down to several hundred micrometers below the skin surface. All three methods allow depth-resolved investigations. While PAS and PDS use a frequency modulation of the excitation beam to reach deeper regions in the sample, the principle of confocal Raman microspectroscopy (CRM) is a movement of the specimen in the focal plane. In consideration of depth measurements PAS and PDS complete the applicable spectrum of CRM, since Raman microscopy requires particular transparent materials.

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