Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field

Edwards, Michael G.; Topp, Edward; Metcalfe, Chris D.; Li, H.; Gottschall, N.; Bolton, P.; Curnoe, W. E.; Payne, Michael A.; Beck, Andrew; Kleywegt, Sonya; Lapen, David R.

doi:10.1016/j.scitotenv.2009.02.028

Cited by 104 publications

(55 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The portion of radioactivity comigrated with nortriptyline and amitriptyline-N-oxide in clay soil was very low (<1%), which was close to the detection limit (the purity of 3 H-amitriptyline is $99%). It must be noted that the loss of one methyl group from amitriptyline-[N-methyl- 3 H] yields a nortriptyline-[N-methyl- 3 H] product with half the specific activity of the parent. Thus, on a molar basis, the nortriptyline yields are double those represented by the accumulated radioactivity, namely 11.2, 1.6, and 5.2% in the loam, clay loam, and sandy loam, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Amitriptyline-[N-methyl- 3 H] hydrochloride (radioactive purity >99%, specific activity, 60 mCi mmol À1 ) was purchased from American Radiolabeled Chemicals. Amitriptyline hydrochloride (purity >98%), nortriptyline hydrochloride (purity >98%), and (AE )-E-10-hydroxylated amitriptyline were purchased from Sigma-Aldrich, Canada (Fig.…”

Section: Materials and Chemicalsmentioning

confidence: 99%

“…A scintillation vial containing 10 ml of water was placed in each jar to maintain soil moisture and prevent desiccation of the soil. Soils were supplemented with 3 H-labeled and unlabeled amitriptyline by adding stock solutions in ethanol to 1-g portions of pulverized air-dried soil, allowing the solvent to evaporate, and then thoroughly mixing this into 49 g (moist wet) of soil to give a total of 50 g. Soils received 1 mg amitriptyline g À1 and 30 k dpm g À1 moist soil, and soil moisture were normalized to 15% in all treatments. Triplicate microcosms were prepared for each treatment, and these microcosms were incubated in darkness at 308C, unless otherwise indicated.…”

Section: Laboratory Incubationsmentioning

confidence: 99%

“…The potential environmental and public health impact of these chemicals is of scientific and regulatory concern [1][2][3][4][5][6]. Major sources for environmental exposure to these chemicals can include the effluent of sewage treatment plants, land application of municipal biosolids (sewage sludge), municipal landfill leachate, and irrigation with reclaimed wastewater [7].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils

Li¹,

Sumarah²,

Topp³

2013

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract-Amitriptyline and nortriptyline are widely used tricyclic antidepressant drugs. They have been detected in wastewater, surface runoff, and effluents from sewage treatment plants. As such, they could potentially reach agriculture land through the application of municipal biosolids or reclaimed water. In the absence of data on their fate in the environment, the persistence and dissipation pathways of radiolabeled amitriptyline were determined in three agriculture soils varying widely in texture and chemical properties (loam soil, clay loam soil, and sandy loam soil). Tritiated amitriptyline was added to laboratory microcosms containing soils, and the metabolism of the extractable 3 H was monitored during incubation at 308C. The total solvent extractable radioactivity decreased in all three soils with times to dissipate 50% of material (DT50) ranging from 34.1 AE 3.2 (loam soil) to 85.3 AE 3.2 d (sandy soil). Nortriptyline (N-desmethyl amitriptyline) and amitriptyline-N-oxide were identified as major transformation products in all three soils by high performance liquid chromatography with photodiode array detector and time-of-flight mass spectrometry (HPLC-TOF-MS/UV). The addition of liquid municipal biosolids to the loam soil had no effect on the dissipation of amitriptyline. The persistence of nortriptyline was evaluated in the loam soil. The DT50 of nortriptyline was 40.5 AE 3.2 d estimated with HPLC-TOF-MS/UV. Approximately 10% of added nortriptyline was converted to hydroxylated products after 50 d of incubation. In summary, amitriptyline persisted in agricultural soils with major dissipation mechanisms, including forming nonextractable residues and producing various transformation products including the psychoactive drug nortriptyline. Environ. Toxicol. Chem. 2013;32:509-516. # 2012 SETAC

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Materials and Chemicalsmentioning

confidence: 99%

Section: Laboratory Incubationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils

Li¹,

Sumarah²,

Topp³

2013

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…For the 216 Class A compounds, the two extraction methods used were described by Edwards et al (2009) as the 217 neutral drug method and the acidic drug method. However, the neutral drugs method with acetone 218 7 and water (3:7) as the ASE extraction solvent (Table S1) gave the highest recoveries in the sludge 219 matrix for this study.…”

mentioning

confidence: 99%

Fate and mass balance of contaminants of emerging concern during wastewater treatment determined using the fractionated approach

Baalbaki

Sultana

Maere

et al. 2016

Science of The Total Environment

View full text Add to dashboard Cite

Contaminants of emerging concern (CECs) are often poorly removed from wastewater using conventional treatment technologies and there is limited understanding of their fate during treatment. Inappropriate sampling strategies lead to inaccuracies in estimating removals of CECs. In this study, we used the “fractionated approach” that accounts for the residence time distribution (RTD) in treatment units to investigate the fate of 26 target CECs in a municipal wastewater treatment plant (WWTP) that includes primary, secondary and tertiary treatment steps[...] Analysis of the selected metabolites demonstrated that negative removals obtained could be explained by transformations between the parent compound and their metabolites. This study contributes to the growing literature by applying the fractionated approach to calculate removal of different types of CECs across each wastewater treatment step. An additional level of understanding of the fate of CECs was provided by mass balance calculations in primary and secondary treatments

show abstract

On the Frontier: Analytical Chemistry and the Occurrence of Illicit Drugs into Surface Waters in the United States

Jones-Lepp

Alvarez

Loganathan

2011

Illicit Drugs in the Environment

View full text Add to dashboard Cite

Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field

Cited by 104 publications

References 65 publications

Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils

Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils

Fate and mass balance of contaminants of emerging concern during wastewater treatment determined using the fractionated approach

On the Frontier: Analytical Chemistry and the Occurrence of Illicit Drugs into Surface Waters in the United States

Contact Info

Product

Resources

About