Phaeohyphomycosis of the nasal sinuses caused by a new species of Exserohilum

Padhye, A. A.; Ajello, Libero; Wieden, Marion A.; Steinbronn, Karen

doi:10.1128/jcm.24.2.245-249.1986

Cited by 45 publications

(15 citation statements)

References 15 publications

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“…Straight, oblong to ellipsoidal; rounded at both ends; trun-Typically four or five septa, 6.8 by 23.3 (4-9 cate, dark hilum; septa light; walls often finely roughsome with three to six septa by [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] ened Bipolaris spicifera Straight, oblong to cylindrical; rounded at both ends;…”

Section: Bipolaris Hawaiiensismentioning

confidence: 99%

Emerging agents of phaeohyphomycosis: pathogenic species of Bipolaris and Exserohilum

McGinnis¹,

Rinaldi²,

Winn³

1986

J Clin Microbiol

175

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Study of numerous living isolates of Bipolaris, Drechslera, Exserohilum, and Helminthosporium spp., as well as a mycological assessment of published case reports of phaeohyphomycosis attributed to these fungi, showed that Bipolaris australiensis, B. hawaiiensis, B. spicifera, Exserohilum longirostratum, E. mcginnisii, and E. rostratum are well-documented pathogens. Conidial shape, septation, and size, hilar characteristics, the origin of the germ tube from the basal cell and, to a lesser extent, from other conidial cells, and the sequence and location of the conidial septa are useful criteria for distinguishing these taxa.

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Section: Bipolaris Hawaiiensismentioning

confidence: 99%

Emerging agents of phaeohyphomycosis: pathogenic species of Bipolaris and Exserohilum

McGinnis¹,

Rinaldi²,

Winn³

1986

J Clin Microbiol

175

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“…A subcutaneous abscess caused by Exserohilum rostratum was diagnosed in 55 year old healthy woman with a subcutaneous abscess and systemic symptoms of nausea, dizziness and chills following minor trauma to her leg [9]. Another case of phaeohyphomycosis of the nasal sinuses caused by a new species of Exserohilum was reported in a 27 year old man with a 6 year history of allergies developed nasal polyps that occluded his nose [4]. The pathogen is usually an environmental contaminant.…”

Section: Discussionmentioning

confidence: 99%

“…The three closely related genera Bipolaris, Drechsleria and Exserohilum are distinguished on the basis of such characters as conidial shape and size, hilar morphology, origin of the germ tubes from the basal or other conidial cells, and the location and sequence of the conidial septa. The only Exserohilum species known as etiologic agents of phaeohyphomycosis in humans and animals are E.rostratum, E.longirostratum and E.meginnisii [4,5]. An aggressive angioinvasive nature and the ability to grow at 400C indicate their potential to be neurotropic pathogens [1].…”

Section: Introductionmentioning

confidence: 99%

A case of subcutaneous phaeohyphomycosis caused by Exserohilum species in an immunocompromised patient

K¹,

Usharani²,

Bondili³

et al. 2013

Our Dermatol Online

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Phaeohyphomycoses are rare fungal infections, caused by dematiaceous fungi, manifested as cutaneous and subcutaneous infections, meningitis, sinusitis, keratitis, osteomyelitis and disseminated infection. This is a case report of a 45year old immuno compromised female on ART (Anti Retroviral therapy) presented with fever and generalized nodular lesions draining pus on face, hands, axilla, groin and labia majora since one month. Biopsy of the subcutaneous nodule on the lateral aspect of the thigh revealed septate fungal hyphae on 10% KOH (10% Potassium Hydroxide) mount. Fungal culture of the biopsy material on SDA (Sabouraud's Dextrose Agar) at 25 0 C showed cotton wooly, dark gray to olivaceous black growth with black reverse and identified as dematiaceous fungi belonging to Exserohilum species by microscopy. The patient was put on Itraconazole 200mg BD in combination with Terbinafine 250mg BD for which she responded with healing of pustular lesions in two weeks and complete remission in two months.

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“…It is postulated that viral infection of the nasal and/or sinus cavities leads to secondary infection of the sinus cavity (55). The pathogens involved in sinusitis are usually bacterial, although they may also be viral or fungal (85)(86)(87)(88)(89)(90)(91).…”

Section: Complications Of Sinus Disease Includementioning

confidence: 99%

“…in the compromised patient (diabetic or immunocompromised), a fungal infection may present as cellulitis and become fulminant, and is often rapidly fatal. Fungal groups that have been implicated in sinusitis include most commonly Aspergillus species, followed by zygomycoses and Pseudallescheria species (88)(89)(90)(91).…”

Section: Complications Of Sinus Disease Includementioning

confidence: 99%

Classification, Diagnosis and Treatment of Sinusitis: Evidence-Based Clinical Practice Guidelines

Noyek¹,

Brodovsky²,

Coyle³

et al. 1998

Canadian Journal of Infectious Diseases

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OBJECTIVE: To provide evidence-based recommendations for classification, diagnosis and treatment of acute, chronic and recurrent acute sinusitis in adults and children.DATA SOURCES: Review articles, textbooks, other published guidelines and recommendations of task force members.STUDY SELECTION: One hundred and seventy-one papers addressing one or all of the objectives.DATA EXTRACTION: Relevant data were collated under each objective.DATA SYNTHESIS: Validity of diagnostic and treatment evidence was assessed by using the methodological recommendations of Sackett et al and the canadian Task Force on Periodic Health Examination, respectively. Where there was a paucity of data, consensus of task force members was reached.CONCLUSIONS: Sinusitis is classified as acute, chronic or recurrent acute disease according to duration and frequency of symptoms and response to therapy (expert opinion). Potential risk factors, concomitant diseases and complications are identified (limited evidence). Diagnosis is based on symptoms, history and physical examination. For adults, independentpredictors of acute sinusitis include maxillary toothache, coloured nasal discharge, poor response to nasal decongestants/antihistamines and mucopurulent nasal secretions (good evidence); for children, cough, nasal discharge and fever are common (good evidence). For chronic disease that persists despite adequate therapy and recurrent acutedisease, referral to a specialist for investigative measures (nasal endoscopy, computed tomography) is often necessary to determine predisposing anatomical features. Level I evidence supports the use of antibiotics for the treatment of sinusitis; selection is based on the local pattern of bacterial resistance, relative efficacy, safety and cost. Amoxicillinclavulanate, cefuroxime axetil, cefixime, ciprofloxacin and clarithromycin are approved for the treatment of acute sinusitis in canada. Amoxicillin, amoxicillin-clavulanate and cefuroxime axetil have been shown to be effective in children. Ciprofloxacin, amoxicillin-clavulanate, clarithromycin and erythromycin have been shown to be effective in chronic disease, although no agents have been approved for this indication. Given changing patterns of bacterial resistance, more up-to-date comparative efficacy data are needed.

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Phaeohyphomycosis of the nasal sinuses caused by a new species of Exserohilum

Cited by 45 publications

References 15 publications

Emerging agents of phaeohyphomycosis: pathogenic species of Bipolaris and Exserohilum

Emerging agents of phaeohyphomycosis: pathogenic species of Bipolaris and Exserohilum

A case of subcutaneous phaeohyphomycosis caused by Exserohilum species in an immunocompromised patient

Classification, Diagnosis and Treatment of Sinusitis: Evidence-Based Clinical Practice Guidelines

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