pH-triggered charge-reversible of glycol chitosan conjugated carboxyl graphene for enhancing photothermal ablation of focal infection

Qian, Wei; Chang, Yan; He, Dengming; Yu, Xunzhou; Yuan, Long; Liu, Menglong; Luo, Gaoxing; Deng, Jun

doi:10.1016/j.actbio.2018.01.022

Cited by 107 publications

(73 citation statements)

References 52 publications

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“…[52] Therefore, MRGOGA can effectively catch and remove bacteria from aqueous solution and rapidly kill them under NIR laser exposure.M oreover,t oi mprovet he bacterialt argeting ability of GMs, bacterial recognition and microenvironment-responsive molecules can be adsorbed or conjugated onto the GMs. [53][54][55] Wang et al modified nanoscale rGO (NRGO) with at argeting molecule, the anti-S. aureus antibody (Ab), through physicaladsorption, and the as-prepared Ab-NRGO is used for the selective photothermal inactivation of bacteria ( Figure 7a). [53] Furthermore, by alteringt he targeting molecule, this platform may be suitable for inactivating other pathogens with high selectivity.Y ang et al grafted rGO with the targeting probes van-comycin and aE u 3 + complex (Eu-Van-rGO) for the simultaneous targeted fluorescence imaging and photothermal ablation of drug-resistant bacteria (Figure 7b).…”

Section: Photoinduced Antimicrobial Behavior Of Gmsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

108

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Since the "birth" of graphene in 2004, two-dimensional (2D) materials have attracted unprecedented research interest from scientists and have stimulated numerous applications in various fields, such as electronic/optical devices, energy storage, catalysis, sensors, and biomedicine. In this review, we summarize recent advances in the antimicrobial applications of 2D materials, such as graphene materials (GMs), layered double hydroxides (LDHs), transition-metal dichalcogenides (TMDs), graphitic carbon nitride (g-C N ), MXenes, black phosphorus (BP), and their derivatives. This review also correlates the unique physicochemical properties of 2D materials with their antimicrobial activities. Finally, some current challenges and future perspectives in this field are also presented.

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Section: Photoinduced Antimicrobial Behavior Of Gmsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

108

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“…Recently, photothermal therapy (PTT) using a NIR laser-absorbing nanomaterial is recognized as one of the most promising strategies for combating bacterial infections [9,10]. Under NIR laser irradiation, the photothermal nanomaterial converts light energy into heat and elevates the local temperature, which can induce the bacterial cell membrane destruction and protein denaturation and the dispersion of biofilms [9,[11][12][13]. PTT offers a lot of advantages, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, localized NIR irradiation can promote blood circulation and relieve inflammation of tissues [15], which is beneficial for wound healing. Up to now, various types of photothermal nanomaterials have been explored for applications in the antibacterial therapy, including carbon-based nanoparticles [9,16], metal nanoparticles [12,17] and polymeric nanoparticles [10,18]. Among of them, graphene, as a monolayer of carbon atoms packed into a dense honeycomb crystal structure, has drawn much attention owing to its special two-dimensional structure, strong mechanical property, high photothermal conversion efficiency and excellent biocompatibility [9,19].…”

Section: Introductionmentioning

confidence: 99%

“…Up to now, various types of photothermal nanomaterials have been explored for applications in the antibacterial therapy, including carbon-based nanoparticles [9,16], metal nanoparticles [12,17] and polymeric nanoparticles [10,18]. Among of them, graphene, as a monolayer of carbon atoms packed into a dense honeycomb crystal structure, has drawn much attention owing to its special two-dimensional structure, strong mechanical property, high photothermal conversion efficiency and excellent biocompatibility [9,19]. In 2013, Wu et al [16] fabricated a magnetic reduced graphene oxide/glutaraldehyde nanocomposite, which could effectively kill Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) when exposed to NIR laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

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A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms

et al. 2020

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Background: Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest. Results: In this study, we developed a multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT and NO release for synergistic therapy against MDR Gram-negative bacteria and their biofilms. When located at the infected sites, TG-NO-B was able to selectively bind to the surfaces of Gram-negative bacterial cells and their biofilm matrix through covalent coupling between the BA groups of TG-NO-B and the bacterial LPS units, which could greatly improve the antibacterial efficiency, and reduce side damages to ambient normal tissues. Upon single NIR laser irradiation, TG-NO-B could generate hyperthermia and simultaneously release NO, which would synergistically disrupt bacterial cell membrane, further cause leakage and damage of intracellular components, and finally induce bacteria death. On one hand, the combination of NO and PTT could largely improve the antibacterial efficiency. On the other hand, the bacterial cell membrane damage could improve the permeability and sensitivity to heat, decrease the photothermal temperature and avoid damages caused by high temperature. Moreover, TG-NO-B could be effectively utilized for synergistic therapy against the in vivo infections of MDR Gram-negative bacteria and their biofilms and accelerate wound healing as well as exhibit excellent biocompatibility both in vitro and in vivo. Conclusions: Our study demonstrates that TG-NO-B can be considered as a promising alternative for treating infections caused by MDR Gram-negative bacteria and their biofilms.

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“…Among the different carbon‐based nanomaterials, graphene and graphene‐derived nanomaterials have emerged with multitude applications, including both therapeutic and diagnostic purposes in the same platform (Gurunathan, Han, Park, & Kim, ; Jaworski et al, ; Ma et al, ; Wang et al, ; Zhang, Xia, Zhao, Liu, & Zhang, ; Zhou et al, ). Graphene is a monolayer material with sp 2 hybridized carbon atoms in a two‐dimensional structure which exhibits unique properties in a wide variety of biotechnological uses such as drug/gene carrier systems, contrast imaging, biosensing, and photothermal therapy (Orecchioni, Cabizza, Bianco, & Delogu, ; Qian et al, ; Yang, Asiri, Tang, du, & Lin, ). Given the specific toxic effects of graphene‐based materials on cancer cells, their anticancer and antimetastatic properties have been characterized (Jaworski et al, ; Russier et al, ; Zhou, Zhang, Zheng, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Systems toxicology assessment revealed the impact of graphene‐based materials on cell cycle regulators

Farahani

Rezaei‐Tavirani

Zali

et al. 2020

J Biomedical Materials Res

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Understanding the cellular and molecular toxicity of graphene and its derivatives is essential for their biomedical applications. Herein, gene expression profile of graphene-exposed cells was retrieved from the Gene expression omnibus database.Differentially expressed genes and their functional roles were then investigated through the pathway, protein-protein interaction (PPI) network, and module analysis.High degree (hub) and high betweenness centrality (bottleneck) nodes were subsequently identified. The functional analysis of central genes indicated that these graphene-gene interactions could be of great value for further investigation. Accordingly, we also followed the expression of five hub-bottleneck genes in graphenetreated murine peritoneal macrophages and human breast cancer cell line by realtime PCR. The five hub-bottleneck genes related to graphene cytotoxicity; CDK1, CCNB1, PLK1, TOP2A, and CCNA2 were identified through network analysis, which were highly correlated with regulation of cell cycle processes. The module analysis indicated the cell cycle pathway to be the predominant one. Gene expression evaluation showed downregulation of these genes in the macrophages and cancer cells treated with graphene. These results provided some new intuitions concerning the graphene-cell interactions and unveiled targeting critical cell cycle regulators. The present study indicated some toxic effects of graphene-based materials through systems toxicology assessment. Integrating gene expression and PPI network may help explaining biological responses of graphene and lead to beneficial impacts in nanomedicine. K E Y W O R D Scell cycle, gene expression, graphene, protein-protein interaction network, systems toxicology

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pH-triggered charge-reversible of glycol chitosan conjugated carboxyl graphene for enhancing photothermal ablation of focal infection

Cited by 107 publications

References 52 publications

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms

Systems toxicology assessment revealed the impact of graphene‐based materials on cell cycle regulators

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