pH‐Sensitive Water‐Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes

Chen, Zhiyong; Xu, Li; Liang, Yuan; Zhao, Meiping

doi:10.1002/adma.200903122

Cited by 133 publications

(74 citation statements)

References 27 publications

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“…The hydrogel was made of a molecularly imprinted poly(methacrylic acid) reticulated using EGDMA as the cross-linker and BPA as the template molecule, and demonstrated excellent pH sensing performances. Zhao et al 284 presented a catalytic system based on an imprinted tetrapolymer of 4-vinylpyridine, hemin, acrylamide, and N-isopropylacrylamide 291 found that salt ions had an influence on template binding to two models of MIPs, targeted towards penicillin G and propranolol, respectively, in water-acetonitrile mixtures. The results showed that in 100% aqueous solution, 3 M salt solutions augmented the binding of both templates, which followed the Hofmeister series with kosmotropic ions promoting the largest increase.…”

Section: View Article Onlinementioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: View Article Onlinementioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Regarding MIPs-based stimuli-responsive catalysts, another interesting investigation was published in 2010 by Chen et al [48]. Nanospheric imprinted hydrogels, shown to be pH-sensitive and water-soluble, were prepared in order to mimic the enzyme horseradish peroxidase (HRP).…”

Section: Polymers With Unusual Reactivitymentioning

confidence: 99%

“…The formation of the dominant Diels-Alder product (the endo-one), was used as a basis for monitoring the Differences in size and charges expression of the hydrogels, depending on the pH. In acidic and basic conditions the hydrogel is swollen, while at pH between 7 and 8, it shrinks [48] Molecularly Imprinted Polymers for Catalysis and Synthesis reaction outcome. At room temperature, an increase up to 20-fold in the reaction rate relative to the non-catalyzed reaction, was observed when the three polymers were used.…”

Section: Polymers With Unusual Reactivitymentioning

confidence: 99%

Molecularly Imprinted Polymers for Catalysis and Synthesis

Mirata

Resmini

2015

Molecularly Imprinted Polymers in Biotechnology

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The area of biomimetic catalysis based on molecular imprinted polymers has progressed considerably over the last two decades, with research efforts focused on developing catalysts for challenging reactions and on understanding the key factors in template structure and polymer morphology that influence efficiency and selectivity. Recent advances and significant achievements in the field presented in this chapter are organized according to four topics: hydrolytic reactions of challenging substrates, oxidase mimics, metallo-enzyme mimics, and polymers that display unusual reactivity, such as in the case of reactions for which enzymes don't exist, such as Diels-Alder and Kemp elimination. For each theme, significant examples for recent literature are presented and discussed.

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“…Under optimal pH conditions (close to the pI of the polymer), the imprinted gel shrunk to the smallest size with an excellent hydrophobic microenvironment in the imprinted nanostructures, which significantly increased the catalytic efficiency ( Figure 6). This remarkably sensitive catalysis in response to pH conditions shows us an effective way to modulate the microenvironment around the catalytic centers for mimetic enzyme [64].…”

Section: Ph-responsive Molecularly Imprinted Polymersmentioning

confidence: 99%

Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

et al. 2015

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Intelligent stimuli-responsive molecularly imprinted polymers (SR-MIPs) have attracted considerable research interest in recent years due to the potential applications in drug delivery, biotechnology and separation sciences. This review comprehensively summarizes various SR-MIPs, including the design and applications of thermo-responsive MIPs, pH-responsive MIPs, photo-responsive MIPs, biomolecule-responsive MIPs and ion-responsive MIPs. Besides the development of current SR-MIPs, the advantages as well as the disadvantages of current SR-MIPs were also displayed from different angles, especially preparation methods and application fields. We believe this review will be helpful to guide the design, development and application of SR-MIPs.Polymers 2015, 7 1690

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pH‐Sensitive Water‐Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes

Cited by 133 publications

References 27 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Molecularly Imprinted Polymers for Catalysis and Synthesis

Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

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