Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

Chen, Wei; Ma, Yue; Pan, Jianmin; Meng, Zihui; Pan, Guoqing; Sellergren, Börje

doi:10.3390/polym7091478

Cited by 113 publications

(52 citation statements)

References 115 publications

(109 reference statements)

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“…These features of stimuli-responsive hydrogels could benefit MIPs performance by reducing non-specific binding and improving transport of the template [51]. The synthesis of smart hydrogel MIPs that can modulate their affinity for the target macromolecules enabling a switchable capacity for the binding and releasing processes according to external stimuli has attracted considerable research interest and has been comprehensively reviewed [52,53]. …”

Section: Polymeric Materialsmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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Biosensors are a promising tool offering the possibility of low cost and fast analytical screening in point-of-care diagnostics and for on-site detection in the field. Most biosensors in routine use ensure their selectivity/specificity by including natural receptors as biorecognition element. These materials are however too expensive and hard to obtain for every biochemical molecule of interest in environmental and clinical practice. Molecularly imprinted polymers have emerged through time as an alternative to natural antibodies in biosensors. In theory, these materials are stable and robust, presenting much higher capacity to resist to harsher conditions of pH, temperature, pressure or organic solvents. In addition, these synthetic materials are much cheaper than their natural counterparts while offering equivalent affinity and sensitivity in the molecular recognition of the target analyte. Imprinting technology and biosensors have met quite recently, relying mostly on electrochemical detection and enabling a direct reading of different analytes, while promoting significant advances in various fields of use. Thus, this review encompasses such developments and describes a general overview for building promising biomimetic materials as biorecognition elements in electrochemical sensors. It includes different molecular imprinting strategies such as the choice of polymer material, imprinting methodology and assembly on the transduction platform. Their interface with the most recent nanostructured supports acting as standard conductive materials within electrochemical biomimetic sensors is pointed out.

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Section: Polymeric Materialsmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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“…Despite the huge potential that a switchable tool for sample preparation has on food science applications, the research developed until now in this area is still relatively unexplored [19]. Nowadays, photo irradiation is emerging as new external stimuli for stimuli-responsive polymeric materials [20,21] since it is convenient to apply and easy to control. The development of molecularly imprinted polymers involves the incorporation of photosensitive chromophores, like azobenzene, stilbene or spiropyran, into the main chain of the polymer.…”

Section: Introductionmentioning

confidence: 99%

“…The uptake/release of the target analyte is promoted by the UVeVis photo-induced trans-cis isomerization of the chromophore owing to the photo-induced changes in orientation and space resulting in a significant alteration of receptor geometry, which affects the binding capacity of the host-guest imprinting system. These photo controllable sorbents could be potentially applied in several fields, namely separation/extraction, intelligent chemical carriers and catalysis [20,21].…”

Section: Introductionmentioning

confidence: 99%

A photoswitchable “host-guest” approach for the selective enrichment of dimethoate from olive oil

García

Carreiro

Ramalho

et al. 2018

Analytica Chimica Acta

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This work describes the development of a new selective photocontrollable molecularly imprinted-based sorbent for the selective enrichment/pre-concentration of dimethoate from spiked olive oil samples. To achieve this goal an improved molecularly imprinted strategy relying on the embedding of a functional monomer containing an azobenzene chromophore as light-responsive element, on the crosslinked tridimensional molecular imprinted network, has been assessed. To address the mechanisms underlying template recognition and uptake/release of the analyte from the functional imprinted material, computational studies using a quantum chemical approach, have been explored. This new functional sorbent provides a straightforward controllable uptake/release of the target template using light as the stimuli tool, which is highly advantageous due to light manipulation characteristics, such as superior clean, precision and remote controllable properties. In general, this work will contribute to the implementation of a photoswitchable analytical methodology that proves to be suitable for the selective isolation and further quantification of dimethoate from olive oil matrices at levels similar to the maximum residues limits imposed by the legislation. The limits of detection, calculated based on 3σ, was 1.6 mgL and the limit of quantification, based on 10σ, was 5.2 mgL. The implemented sample preparation shows high reproducibility and recoveries (93.3 ± 0.4%).

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“…After the template is eluted, recognition sites in synthetic polymers exhibit a high selectivity for rebinding the target molecules and the similar structures (Chen et al, 2015; Randa et al, 2015). MIPs possess great application in a various of areas, such as drugs delivery (Li et al, 2014), biosensors (Altintas et al, 2015; Wang et al, 2016), and separation science (Takuya et al, 2015), owing to the advantages of easier preparation and high selectivity and low cost.…”

Section: Introductionmentioning

confidence: 99%

Porous and Magnetic Molecularly Imprinted Polymers via Pickering High Internal Phase Emulsions Polymerization for Selective Adsorption of λ-Cyhalothrin

Pan

et al. 2017

Front. Chem.

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A novel macroporous magnetic molecularly imprinted polymer (MMIPs) of was prepared by W/O Pickering (high internal phase emulsions) HIPEs polymerization, and then it was adopted as adsorbent for selective adsorption of λ-cyhalothrin (LC). In static conditions, adsorption capacity of LC increased rapidly in the first 60 min and reached to equilibrium in ~2.0 h. Excellent conformity of the second-order model confirmed the chemical nature of the interaction between the LC and imprinted sites. The fitting adsorption isotherm was a Langmuir type, and the maximum monolayer adsorption capacity at 298 K was 404.4 μmol g−1. Thermodynamic parameters suggested the specific adsorption at 298 K was an exothermic, spontaneous, and entropy decreased process. Competitive recognition studies of the MMIPs were performed with diethyl phthalate (DEP) and the structurally similar compound fenvalerate (FL), and the MMIPs, which displayed high selectivity for LC.

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Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

Cited by 113 publications

References 115 publications

Imprinting Technology in Electrochemical Biomimetic Sensors

Imprinting Technology in Electrochemical Biomimetic Sensors

A photoswitchable “host-guest” approach for the selective enrichment of dimethoate from olive oil

Porous and Magnetic Molecularly Imprinted Polymers via Pickering High Internal Phase Emulsions Polymerization for Selective Adsorption of λ-Cyhalothrin

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