Molecularly Imprinted Polymers for Catalysis and Synthesis

Abstract

The area of biomimetic catalysis based on molecular imprinted polymers has progressed considerably over the last two decades, with research efforts focused on developing catalysts for challenging reactions and on understanding the key factors in template structure and polymer morphology that influence efficiency and selectivity. Recent advances and significant achievements in the field presented in this chapter are organized according to four topics: hydrolytic reactions of challenging substrates, oxidase mimics, metallo-enzyme mimics, and polymers that display unusual reactivity, such as in the case of reactions for which enzymes don't exist, such as Diels-Alder and Kemp elimination. For each theme, significant examples for recent literature are presented and discussed.

Cost-Effective Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) and Based on Imprinted Receptors for Fluvoxamine Assessment

“…According to suitable therapeutic drug monitoring purposes, looking forward to predetermined recognition ability, relatively easy, low cost of preparation and mechanical and chemical stability, molecular imprinted polymers (MIPs) have a wide attention and have been used for various applications, such as catalysis [38], quantification of toxins in food matrices [36,39], solid-phase extraction (SPE) [40], drug delivery [41,42], biological antibodies and receptors systems [43,44] and finally chemical sensors [45,46]. Exceptional properties of MIPs based on their synthesis procedure and their high selectivity against a specific drug molecule returns to the presence of specific recognition sites within their cavities [47].…”

Molecularly Imprinted Materials for Selective Biological Recognition

“…As well known, structure determines nature of substances. Considering diverse applications of imprinted materials in different fields, more emphasis and design should be put on the size, morphology and properties of imprinted materials themselves. For example, in the field of electrochemical sensing, facile to be polymerized on electrodes, high specific surface area, and superior mechanical strength are characteristics required of imprinted materials .…”

Improved chiral electrochemical recognition of tryptophan enantiomers based on three‐dimensional molecularly imprinted overoxidized polypyrrole/MnO2/carbon felt composites

“…Molecular imprinting technology, a synthesized artificial receptor with specific recognition sites for the target template molecules, has attracted enormous interest due to its wide application in affinity separation, chemical and biological sensing, solid‐phase extraction, drug delivery, cell and tissue imaging, and catalysis .…”

“…1 Molecular imprinting technology, a synthesized artificial receptor with specific recognition sites for the target template molecules, has attracted enormous interest due to its wide application in affinity separation, 2 chemical and biological sensing, 3,4 solid-phase extraction, 5 drug delivery, 6 cell and tissue imaging, 7 and catalysis. 8 Among them, chiral separation and analysis using molecularly imprinted polymers (MIPs) has been growing steadily. 9,10 Moreover, molecular imprinting on the surface of nanomaterials for chiral recognition has developed widely due to its unique advantages such as fast electron facilitation, increased active area of the surface of the MIPs film, faster binding kinetics, higher binding capacity and easier diffusion of the analyte to the imprinted cavities.…”