pH Sensitive Soft Contact Lens for Selective Drug-Delivery

Kim, Guenhei; Kim, Hyeok Jung; Noh, Hyeran

doi:10.1007/s13233-018-6029-9

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…For example, some studies have investigated the development of a new drug delivery system to decrease side effects and increase the efficiency of drug delivery based on the manufacture of hydrogel beads for use as a basil seed mucilage (BSM)-based drug delivery system and sodium alginate (SA) [ 61 ]; as well, another study developed a pH-sensitive hydrogel system based on fenugreek seed mucilage, extracted from Trigonella foenum-graecum seeds, to improve the oral bioavailability of methotrexate (MTX) [ 62 ]. In the same line of research, research has studied contact lenses as drug delivery media and the effect of physiological tear pH on drug release behavior [ 63 ]. pH-responsive dried hydrogels have been developed to indicate the healing degree of a wound [ 64 ].…”

Section: Basic Concepts Of Hydrogels In Biomedicinementioning

confidence: 99%

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Revete

Aparicio

Cisterna

et al. 2022

International Journal of Biomaterials

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Due to their particular water absorption capacity, hydrogels are the most widely used scaffolds in biomedical studies to regenerate damaged tissue. Hydrogels can be used in tissue engineering to design scaffolds for three-dimensional cell culture, providing a novel alternative to the traditional two-dimensional cell culture as hydrogels have a three-dimensional biomimetic structure. This material property is crucial in regenerative medicine, especially for the nervous system, since it is a highly complex and delicate structure. Hydrogels can move quickly within the human body without physically disturbing the environment and possess essential biocompatible properties, as well as the ability to form a mimetic scaffold in situ. Therefore, hydrogels are perfect candidates for biomedical applications. Hydrogels represent a potential alternative to regenerating tissue lost after removing a brain tumor and/or brain injuries. This reason presents them as an exciting alternative to highly complex human physiological problems, such as injuries to the central nervous system and neurodegenerative disease.

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Section: Basic Concepts Of Hydrogels In Biomedicinementioning

confidence: 99%

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Revete

Aparicio

Cisterna

et al. 2022

International Journal of Biomaterials

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“…White et al [ 136 ] loaded 120 kDa HPMC onto silica hydrogel lenses by the molecular imprinting technique and released approximately 1000 µg HPMC at a constant flow rate of 16 µg/day for 60 days during the whole continuous wearing period. Kim et al [ 101 , 102 ] loaded HPMC into the pH-sensitive hydrogel contact lens, which can regulate the release of HPMC through changes in the pH and is effective against dry eye disease.…”

Section: Hydrogel Contact Lenses For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from the eye surface. To address these problems, hydrogel-based materials were designed to detect biomarkers or act as drug delivery systems by taking advantage of their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability. Biosensors prepared using biocompatible hydrogels can be sensitive in diagnosing DED, and the designed hydrogels can also improve the drug bioavailability and retention time for more effective and long-term treatment. This review summarizes recent advances in the use of hydrogels for diagnosing and treating dry eye, aiming to provide a novel reference for the eventual clinical translation of hydrogels in the context of dry eye disease.

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“…Noh et al (2017) prepared the hydrogel solution by adding a crosslinking agent (EGDMA) and initiator (AIBN) to HEMA. 40 Two different ionic polymer groups (poly(vinylpyrrolidone) PVP, poly(N-isopropyl acrylamide NIPAAm) were used in this study (Figure 5). This solution was then filled onto plastic molds and the polymerization took place using an oven at 100°C.…”

Section: Fabrication Processesmentioning

confidence: 99%

<p>Healthcare Applications of pH-Sensitive Hydrogel-Based Devices: A Review</p>

Hendi¹,

Hassan²,

Elsherif³

et al. 2020

IJN

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pH-sensitive hydrogels have been developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivitya sensitivity of up to 10 −5 pH units has already been established. Recently, pH-sensitive hydrogels have shown to be very useful in biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes have also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses.

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pH Sensitive Soft Contact Lens for Selective Drug-Delivery

Cited by 13 publications

References 30 publications

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

<p>Healthcare Applications of pH-Sensitive Hydrogel-Based Devices: A Review</p>

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