The purpose of this study is to assess the quantity and quality of myopia related articles from 2001 to 2021 using bibliometric methods. The number of published articles and citations, the correlation analysis between gross domestic product (GDP) and annual publication number and citations was investigated. The proportion of myopia articles from East Asia accounted for 55.28% in 2021. The researchers from China published the most articles on myopia during 2001 to 2021, followed by Japan and South Korea. The annual number of articles and citations from China and South Korea showed an exponential increase with strong positive correlation with GDP. All 3 countries in East Asia are mainly researching refractive surgery, prevalence, and glaucoma, and research on children’s myopia is particularly active in China, and in Japan. The researchers from East Asia published more than half of articles on myopia since 2019, in order of China, Japan, and South Korea. The annual number of articles and citations from China and South Korea showed an exponential increase with strong positive correlation with GDP whereas those from Japan did not. All 3 countries are mainly researching refractive surgery, and glaucoma, and research on children’s myopia is particularly active in China, and in Japan.
Poorly soluble lidocaine and lipophilic vitamin E were phase-separated and polymerized with monomer to form contact lenses. The physical properties and drug release of the manufactured lenses were studied. The used drugs were lidocaine, for local anesthesia, and vitamin E, anti-cataract effect. The HEMA lenses were thermally polymerized with coacervated lidocaine and vitamin E. We measured the light transmittance and water content of drug-containing contact lenses. Optical microscopes and particle size analyzers were used for surface and particle analysis. As a result, the light transmittance of the coacervation drug lens was lower than that of the no-drug lens. However, water content of coacervated drug lens was slightly increased and the drug releasing period was prolonged. The preparation of coacervated drugs enables sustained release of the hardly soluble drugs in the lens. The contact lenses containing coacervated drugs can be used as drug delivery lenses for the prolonged treatment of eye diseases.
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