Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Li, Qiaoqiao; Cao, Yifeng; Wang, Ping

doi:10.3390/gels8120816

Cited by 9 publications

(1 citation statement)

References 146 publications

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“…As an important factor for treating ocular diseases, − the effect of the GE concentration on the friction behavior of the composite hydrogels was studied. The experimental setup diagram is shown in Figure S1.…”

Section: Resultsmentioning

confidence: 99%

Superlubricity Achieved by a Transparent Poly(vinylpyrrolidone) Composite Hydrogel with Glycerol Ethoxylate in Ocular Conditions

Wang,

Zhao,

et al. 2024

Langmuir

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Efficient and stable ocular lubrication is pivotal in safeguarding eye tissues from wear, especially under repetitive strain due to frequent blinking. Hydrogels have been reported to possess adjustable mechanical properties, biocompatibility, durability, and elevated water content and extensive utilization in medical fields. In this work, a kind of visible photo-cross-linking poly(vinylpyrrolidone) (PVP) hydrogel was designed and synthesized using 1-vinyl-2-pyrrolidone (NVP) and poly(ethylene glycol) diacrylate (PEGDA). To optimize the structure and improve the lubrication performance of hydrogels, we prepared and investigated glycerol ethoxylate (GE)-introduced composite hydrogels (GE/PVP). The results show that the addition of 3 wt % GE helped the hydrogel to form a uniform and dense porous matrix and reduce the frictional coefficient (COF) by over 50%, achieving superlubricity (COF ≈ 0.005). However, with the excessive increase of GE (6 wt %), the structure of the hydrogel is destroyed, inducing pore walls to thin and expand. After that, a lubrication mechanism of the GE/PVP composite hydrogel was proposed, in which the addition of GE reduced the surface tension of the hydrogel, enhanced the hydration ability of the hydrogel, and thus decreased the friction between sliding surfaces. Besides, the cytotoxicity tests show that the composite hydrogels possess good biocompatibility. Overall, the as-synthesized hydrogels hold great potential as lubricating medium for use in ocular applications.

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Section: Resultsmentioning

confidence: 99%

Superlubricity Achieved by a Transparent Poly(vinylpyrrolidone) Composite Hydrogel with Glycerol Ethoxylate in Ocular Conditions

Wang,

Zhao,

et al. 2024

Langmuir

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Vinyl Polymers as Key Materials in Contact Lens Design: A Review of Progress and Future Directions

Shaker,

Al‐Amiery,

Isahak

et al. 2024

Starch Stärke

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Vinyl polymers, crucial in contemporary contact lens design, present unique attributes with promising implications for vision correction. This comprehensive review navigates the trajectory and future trajectories of vinyl polymer‐based contact lenses. The introduction underscores the vital role of contact lenses in vision correction and positions vinyl polymers as ideal materials due to their exceptional properties. Delving into material specifics—high oxygen permeability, optical clarity, surface wettability, and mechanical strength—the analysis emphasizes their influence on corneal health, comfort, and durability. The versatility of manufacturing techniques, encompassing spin casting, molding processes, polymerization, and surface modification, underscores their feasibility in crafting high‐quality lenses. Examining clinical applications, encompassing daily disposables, extended wear, silicone hydrogel, and specialty lenses, alongside biocompatibility assessments and user feedback, provides a nuanced understanding of vinyl polymer‐based lens effectiveness. The article candidly addresses challenges—dehydration, deposits, mechanical stability, and durability—alongside regulatory considerations. Future prospects involve novel formulations, smart materials, bioinspired designs, and noninvasive technologies to amplify comfort and performance. In conclusion, this review distills progress, acknowledges challenges, and charts a sanguine course for vinyl polymer materials in advancing contact lens design, envisioning a future marked by enhanced vision correction technologies.

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Achieving net-zero in the dry eye disease care pathway

Latham,

Williams,

Grover

et al. 2023

Eye

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Climate change is a threat to human health and wellbeing across the world. In recent years, there has been a surge in awareness of this crisis, leading to many countries and organisations setting “net-zero” targets. This entails minimising carbon emissions and neutralising remaining emissions by removing carbon from the atmosphere. At the 2022 United Nations Climate Change Conference (COP27), commitments to transition away from fossil fuels and augment climate targets were underwhelming. It is therefore imperative for public and private sector organisations to demonstrate successful implementation of net-zero and set a precedent for the global political consensus. As a top 10 world employer, the United Kingdom National Health Service (NHS) has pledged to reach net-zero by 2045. The NHS has already taken positive steps forward, but its scale and complexity as a health system means stakeholders in each of its services must highlight the specifications for further progress. Dry eye disease is a chronic illness with an estimated global prevalence of 29.5% and an environmentally damaging care pathway. Moreover, environmental damage is a known aggravator of dry eye disease. Worldwide management of this illness generates copious amounts of non-recyclable waste, utilises inefficient supply chains and involves recurrent follow-up appointments and prescriptions. By mapping the dry eye disease care pathway to environmental impact, in this review we will highlight seven key areas in which reduced emissions and pollution could be targeted. Examining these approaches for improved environmental sustainability is critical in driving the transformation needed to preserve our health and wellbeing.

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Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cited by 9 publications

References 146 publications

Superlubricity Achieved by a Transparent Poly(vinylpyrrolidone) Composite Hydrogel with Glycerol Ethoxylate in Ocular Conditions

Superlubricity Achieved by a Transparent Poly(vinylpyrrolidone) Composite Hydrogel with Glycerol Ethoxylate in Ocular Conditions

Vinyl Polymers as Key Materials in Contact Lens Design: A Review of Progress and Future Directions

Achieving net-zero in the dry eye disease care pathway

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