pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

Tomić, Simonida Lj.; Babić, Marija M.; Antić, Katarina M.; Vuković, Jovana S.; Malešić, Neda B.; Filipović, Jovanka M.

doi:10.1007/s13233-014-2172-0

Cited by 17 publications

(11 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The FTIR spectra of PHEMA, PHEMA/A/GO, and PHEMA/G/GO samples are shown in Figure 1 . The PHEMA spectrum showed: O–H stretching vibration at approximately 3431 cm −1 , strong C=O vibration at 1716 cm −1 and C–H stretching vibrations at 2929 cm −1 and 2885 cm −1 [ 29 ]. FT-IR spectra of the PHEMA/A/GO and PHEMA/G/GO materials exhibited above listed PHEMA signals, gelatin (N–H stretching vibration around 3354 cm −1 , C–H stretching at 3003 cm −1 , C=O stretching at 1701 cm −1 for amide I, N–H definition at 1630 cm −1 for the amide II ) and alginate (1278 cm −1 C–O stretching, 1160 cm −1 C–C stretching, 1017 cm −1 C–O–C stretching) vibrations and the type and ratio of the component influenced on the intensity of the peaks [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials

Radić

Filipović

Vukomanović

et al. 2021

Gels

Self Cite

View full text Add to dashboard Cite

The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching method; this is also the first time this method has been used to incorporate nanocolloidal graphene oxide through the hydrogel and simultaneously form porous structures. The effects of a material’s composition on its chemical, morphological, mechanical, and swelling properties, as well as on cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), measurements of Young’s modulus, gravimeter method and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa), curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize tissue regeneration treatments by coupling the hydrogels with cells and different active agents to create material/biofactor hybrids with new levels of biofunctionality.

show abstract

Section: Resultsmentioning

confidence: 99%

Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials

Radić

Filipović

Vukomanović

et al. 2021

Gels

Self Cite

View full text Add to dashboard Cite

show abstract

“…Acrylate-based polymers tend to swell with an increase in pH, which tends to accelerate the release of a loaded AI. 25 , 26 The effects that soil characteristics have on release kinetics and formulation durability certainly require further systematic study considering a larger number of soil types.…”

Section: Resultsmentioning

confidence: 99%

“…The faster release rate measured in the sand could not be explained by differences in the soil pH value (5.2 and 7.2 for the sand and loam, respectively). Acrylate-based polymers tend to swell with an increase in pH, which tends to accelerate the release of a loaded AI. , The effects that soil characteristics have on release kinetics and formulation durability certainly require further systematic study considering a larger number of soil types.…”

Section: Resultsmentioning

confidence: 99%

Impacts of (Nano)formulations on the Fate of an Insecticide in Soil and Consequences for Environmental Exposure Assessment

Kah

Weniger

Hofmann

2016

Environ. Sci. Technol.

View full text Add to dashboard Cite

The development of nanopesticides has recently received an increased level of attention. However, there are very few data about the environmental fate of these new products, and it is not known whether nanoformulations can be evaluated within the current pesticide regulatory framework. Sorption and degradation parameters of the insecticide bifenthrin were measured in two soils for (i) the pure active ingredient, (ii) three nanoformulations, and (iii) a commercially available formulation. In most cases, fate parameters derived for the nanopesticides were significantly different from those derived for the pure active ingredient (factors of up to 10 for sorption and 1.8 for degradation), but discrepancies were not easy to relate to the characteristics of the nanocarriers. In some cases, differences were also observed between the commercial formulation and the pure active ingredient (factors of up to 1.4 for sorption and 1.7 for degradation). In the regulatory context, the common assumption that formulations do not influence the environmental fate of pesticide active ingredients after application seems therefore not always adequate. In the absence of direct measurement, an inverse modeling approach was successfully applied to evaluate the durability of the formulations in soil (release half-life ranged between 11 and 74 days). Predicted groundwater concentrations very much depended on the modeling approach adopted but overall suggest that the nanoformulations studied could reduce losses to groundwater.

show abstract

“…Tomi c et al reported the in vitro release of Cephalexin in PBS (pH ¼ 7.4) at 37 C from the 2-hydroxyethyl methacrylate, itaconic acid and poly (alkylene glycol) methacrylates based hydrogel. The hydrogel releases less than 80% of drug within 10 h and ~100% release after 90 h [16]. Further, steady release of drug is observed after the initial burst release.…”

Section: Loading and In Vitro Release Of Cephalexinmentioning

confidence: 93%

“…Limited studies of release of Cephalexin by hydrogels are being reported in the literature. The Cephalexin delivery of hydrogel formed by 2-hydroxyethyl methacrylate, itaconic acid and poly (alkylene glycol) methacrylates is reported by Tomi c et al [16]. Barkhordari and Yadollahi reported enhanced protection and controlled liberation of Cephalexin drug in gastrointestinal tract using CMC encapsulated layered double hydroxides-drug nanohybrids [14].…”

Section: Introductionmentioning

confidence: 93%

Development of microcrystalline cellulose based hydrogels for the in vitro delivery of Cephalexin

Kundu

Banerjee

2020

Heliyon

View full text Add to dashboard Cite

Three hydrogels namely, microcrystalline cellulose (MCC), microcrystalline cellulose-carboxymethyl cellulose (MCC-CMC) and microcrystalline cellulose-xylan (MCC-xylan) are synthesized using ethylene glycol diglycidyl ether as crosslinker. For the chemical characterization, FT-IR spectroscopy is adopted, whereas gel fraction and swelling ratio are used for the physical characterization of the hydrogels. Coarse morphology of hydrogels is further visualized by microscopic observation. The rheological characterization proves that MCC-CMC gel withstands higher strain to resist permanent deformation than the other two gels. The hydrogels are used for the loading and in vitro release of Cephalexin. The in vitro delivery is carried out in various simulated body fluids such as phosphate buffer saline (PBS), artificial intestinal fluid (AIF) and artificial gastric fluid (AGF). MCC-CMC is observed to deliver Cephalexin individually

show abstract

pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

Cited by 17 publications

References 54 publications

Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials

Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials

Impacts of (Nano)formulations on the Fate of an Insecticide in Soil and Consequences for Environmental Exposure Assessment

Development of microcrystalline cellulose based hydrogels for the in vitro delivery of Cephalexin

Contact Info

Product

Resources

About