Development of microcrystalline cellulose based hydrogels for the in vitro delivery of Cephalexin

Kundu, Debashis; Banerjee, Tamal

doi:10.1016/j.heliyon.2019.e03027

Cited by 40 publications

(24 citation statements)

References 33 publications

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“…The difference in the pH of dissolution mediums did not significantly affect the drug release profile of CS, SMCC, and ALM formulations, while the low pH condition slightly improved drug release from the PMSS and PGS formulations. In contrast, the HFEC formulation showed a slower drug release in acidic medium condition due to the decrease in swellability of MCC in acidic medium [44].…”

Section: Formulation Studymentioning

confidence: 81%

Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System

et al. 2021

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A co-processed, rice starch-based excipient (CS), previously developed and shown to exhibit good pharmaceutical properties, is investigated as an all-in-one excipient for direct compression (DC). An SeDeM-ODT expert system is applied to evaluate the formulation containing CS, in comparison with those containing the physical mixture and the commercial DC excipients. The results revealed that CS showed acceptable values in all six incidence factors of the SeDeM-ODT diagram. In addition, the comprehensive indices (IGC and IGCB) were higher than 5.0, which indicated that CS could be compressed with DC technique without additional blending with a disintegrant in tablet formulation. The formulation study suggested that CS can be diluted up to 60% in the formulation to compensate for unsatisfactory properties of paracetamol. At this percentage, CS-containing tablets exhibited narrow weight variation (1.5%), low friability (0.43%), acceptable drug content (98%), and rapid disintegration (10 s). The dissolution profile of CS displayed that more than 80% of the drug content was released within 2 min. The functionality of CS was comparable to that of high functionality excipient composite (HFEC), whereas other excipients were unsuccessful in formulating the tablets. These results indicated that CS was a suitable all-in-one excipient for application in DC of tablets.

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Section: Formulation Studymentioning

confidence: 81%

Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System

et al. 2021

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“…Polimer yang banyak digunakan bersifat biodegradable, baik dari polimer alami maupun sintesis [7] . Salah satu jenis polimer alami yang sering digunakan yaitu berasal dari golongan polisakarida, seperti kitosan, selulosa, pektin, dan alginat [8][9][10][11][12][13][14][15][16][17].…”

Section: Pendahuluanunclassified

“…FTIR dan SEM [11] Tiamin (TM) -TM 375 mg/75mL -CS 360 mg/72mL TPP 60 mg/24mL 1) [13] 2) [14] Teofilin (TF) 1) [15] 2) [34] 3) [32] Tabel 1. Aplikasi polimer golongan polisakarida untuk enkapsulasi zat aktif 1) [9] 2) [4] Vankomisi n (VN)…”

Section: Efektivitas Enkapsulasi Dari Polimer Polisakaridaunclassified

Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

Marvita¹,

Chaerunisaa²,

Sopyan³

2021

Maj. Farmasetika

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Obat merupakan zat aktif yang bersifat asam atau basa. Beberapa zat aktif memiliki stabilitas yang rendah dan pelepasan obat yang kurang terkontrol. Masalah ini dapat diatasi dengan mengenkapsulasi zat aktif tersebut menggunakan polimer bersifat biodegradable, salah satunya polimer golongan polisakarida yang telah banyak digunakan seperti alginat, kitosan, pektin, dan selulosa. Enkapsulasi zat aktif telah menghasilkan banyak sifat penting seperti penghantaran obat lepas lambat atau terkontrol, peningkatan stabilitas, dan peningkatan bioavailabilitas sehingga dapat meningkatkan kesesuaian untuk aplikasinya. Artikel ini dibuat dengan menggunakan metode pencarian referensi secara online yang berasal dari free database “sciencedirect.com” dari tahun 2012 – 2021. Artikel ini akan membahas beberapa penggunaan polimer golongan polisakarida untuk ekapsulasi zat aktif dengan perbedaan sifat keasaman. Berdasarkan beberapa data penelitian yang terkumpul, membuktikan keberhasilan polimer polisakarida dalam mengenkapsulasi zat aktif yang bersifat asam dan basa. Parameter keberhasilan yang dinilai dalam artikel ini untuk enkapsulasi zat aktif adalah nilai efisiensi enkapsulasi dan pelepasan obat. Zat aktif yang bersifat asam cenderung memiliki efisiensi enkapsulasi yang lebih tinggi daripada zat aktif bersifat basa. Namun, tidak memberikan perbedaan pelepasan obat pada kondisi cairan lambung dan cairan usus. Zat aktif dengan sifat keasaman yang berbeda sama-sama memiliki pelepasan obat tertinggi pada kondisi basa.

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“…MCC (microcrystalline cellulose) is one of the most frequent used filler materials in the pharmaceutical industry to produce direct compressible tablets and beads. MCC is purified cellulose that is partially depolymerized and is obtained from fibrous plant material (e.g., wood) [58,59]. In a recent study, the antioxidant quercetin was combined with MCC via a crystallization technique called fluid bed crystallization.…”

Section: Soluble and Insoluble Filler Materialsmentioning

confidence: 99%

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

et al. 2020

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Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds is usually very low as a result of their poor solubility properties. In order to improve the bioavailability of these poorly soluble drugs, formulation strategies have been applied as a means to improve their aqueous solubility and dissolution rates. With respect to formulation approaches, excipients can be incorporated in the formulation to assist in the dissolution process of the drug, or specialized dosage forms can be formulated that improve dissolution rate through various mechanisms. This paper provides an overview of selected excipients (e.g., alkalinizing agents, surfactants and sugars) that can be used in formulations to increase the dissolution rate as well as specialized dosage forms such as self-emulsifying delivery systems and formulation techniques such as inclusion complexes and solid dispersions. These formulation approaches are discussed with available examples with specific reference to positive outcomes in terms of drug solubility and bioavailability enhancement.

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Development of microcrystalline cellulose based hydrogels for the in vitro delivery of Cephalexin

Cited by 40 publications

References 33 publications

Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System

Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System

Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

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