pH-Responsive unimolecular micelles based on amphiphilic star-like copolymers with high drug loading for effective drug delivery and cellular imaging

Shi, Xiaoxiao; Ma, Xiaoqian; Hou, Meili; Gao, Yong-E; Bai, Shuang; Xiao, Bo; Xue, Peng; Kang, Yuejun; Xu, Zhigang; Li, Chang Ming

doi:10.1039/c7tb01477e

Cited by 47 publications

(25 citation statements)

References 61 publications

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“…Poly [2-(diisopropylamino) ethyl methacrylate] (PDPA) and its derivates with a wide pKa range between 4.0 and 7.4 is also an important pH-responsive protonated polymer [65] . Examples include amphiphilic PEG-b-PDPA copolymer [66] and poly [2-(diisopropylamino) ethyl methacrylate]-b-poly [(ethylene glycol) methyl ether methacrylate] (PDPA-b-POEGMA) [67] . These two copolymers had a pH transition at 6.2 and exhibited much sharper and quicker pH response in the acidic endocytic organelles than many previous pH-sensitive nanosystems [68 , 69] .…”

Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

“…These two copolymers had a pH transition at 6.2 and exhibited much sharper and quicker pH response in the acidic endocytic organelles than many previous pH-sensitive nanosystems [68 , 69] . Gao et al reported star-like NPs where PDPA-b-POEGMA anchored on a β-CD core for simultaneous controllable drug delivery [67] . Due to the presence of the PDPA blocks, the copolymers were hydrophobic at pH 7.4 which enabled the efficient loading of hydrophobic drugs such as doxorubicin (DOX) in their hydrophobic layer, while an acidic environment ( e.g.…”

Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

“…Due to the presence of the PDPA blocks, the copolymers were hydrophobic at pH 7.4 which enabled the efficient loading of hydrophobic drugs such as doxorubicin (DOX) in their hydrophobic layer, while an acidic environment ( e.g. pH 5.0) could trigger the hydrophobicity-hydrophilicity transition of PDPA blocks to induce drug release for cancer therapy [66 , 67] . In another study by the same group, various analogues of PDPA containing tertiary amines with linear or cyclic side chains were utilized to delivery ovalbumin for cancer immunotherapy [70] .…”

Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

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Tumor microenvironment responsive drug delivery systems

Chen

Yan

et al. 2020

Asian Journal of Pharmaceutical Sciences

142

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Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas. With the introduction of several additional functionalities, the properties of these smart DDSs including size, surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting, and eventually achieve desired drug release for an optimized therapeutic efficiency. This review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug delivery. Dynamic targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli, including pH, glutathione, adenosine-triphosphate, reactive oxygen species, enzyme and inflammatory factors are summarized. Special emphasis of this review is placed on their responsive mechanisms, drug loading models, drawbacks and merits. Several typical multi-stimuli responsive DDSs are listed. And the main challenges and potential future development are discussed.

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Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

Section: Stimuli Triggered Drug Deliverymentioning

confidence: 99%

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Tumor microenvironment responsive drug delivery systems

Chen

Yan

et al. 2020

Asian Journal of Pharmaceutical Sciences

142

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“…Based on these significant differences in microenvironment, a series of stimulus-responsive polymeric micelles have been exploited to control the release of the anticancer drugs at the expected target sites. For example, researchers used the weak acidity of tumor tissues and developed a series of pH-responsive drug controlled-release systems, which can accept appropriate pH changes in response to acidic fluctuation of the tumor tissues [24,25,26].…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Micelles Assembled by Three-Armed Degradable Block Copolymers with a Cholic Acid Core for Drug Controlled-Release

et al. 2019

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One of the most famous anticancer drugs, paclitaxel (PTX), has often been used in drug controlled-release studies. The polymers derived from bio-compound bile acids and degradable poly(ε-caprolactone) (PCL) form a reservoir and have been used as a drug delivery system with great advantages. Herein, we grafted poly(N,N-diethylaminoethyl methacrylate) and poly(poly(ethylene glycol) methyl ether methacrylate) into the bile acid-derived three-armed macroinitiator CA-(PCL)3, resulting in the amphiphilic block copolymers CA-(PCL-b-PDEAEMA-b-PPEGMA)3. These pH-responsive three-armed block copolymers self-assembled into micelles in aqueous solution and PTX was encapsulated into the micellar core to form PTX-loaded micelles with a drug loading of 29.92 wt %. The micelles were stable in PBS at pH 7.4 and showed a pH-triggered release behavior of PTX under acidic environments, in which 55% of PTX was released at pH 5.0 in 80 h. These cholic acid-based functionalized three-armed block polymers present good biocompatibility, showing great potential for drug controlled-release.

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“…The number of initiating groups on this macromolecule codes the number of arms in the synthesized star polymer. Moreover, by extension of ω-chain ends on the periphery of the star we can easily introduce a next segment to the polymer [ 22 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of naturally-derived macromolecules through simplified electrochemically mediated ATRP

Chmielarz¹,

Pacześniak²,

Rydel-Ciszek³

et al. 2017

Beilstein J. Org. Chem.

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The flavonoid-based macroinitiator was received for the first time by the transesterification reaction of quercetin with 2-bromoisobutyryl bromide. In accordance with the “grafting from” strategy, a naturally-occurring star-like polymer with a polar 3,3',4',5,6-pentahydroxyflavone core and hydrophobic poly(tert-butyl acrylate) (PtBA) side arms was synthesized via a simplified electrochemically mediated ATRP (seATRP), utilizing only 78 ppm by weight (wt) of a catalytic CuII complex. To demonstrate the possibility of temporal control, seATRP was carried out utilizing a multiple-step potential electrolysis. The rate of the polymerizations was well-controlled by applying optimal potential values during preparative electrolysis to prevent the possibility of intermolecular coupling of the growing polymer arms. This appears to be the first report using on-demand seATRP for the synthesis of QC-(PtBA-Br)5 pseudo-star polymers. The naturally-derived macromolecules showed narrow MWDs (Đ = 1.08–1.11). 1H NMR spectral results confirm the formation of quercetin-based polymers. These new flavonoid-based polymer materials may find applications as antifouling coatings and drug delivery systems.

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pH-Responsive unimolecular micelles based on amphiphilic star-like copolymers with high drug loading for effective drug delivery and cellular imaging

Abstract: A theranostic nanoplatform based on pH-responsive amphiphilic star-like copolymers for theranostic and NIR imaging applications.

Cited by 47 publications

References 61 publications

Tumor microenvironment responsive drug delivery systems

Tumor microenvironment responsive drug delivery systems

pH-Responsive Micelles Assembled by Three-Armed Degradable Block Copolymers with a Cholic Acid Core for Drug Controlled-Release

Synthesis of naturally-derived macromolecules through simplified electrochemically mediated ATRP

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