pH/NIR-responsive semiconducting polymer nanoparticles for highly effective photoacoustic image guided chemo-photothermal synergistic therapy

Yu, Xiaojiang; Chen, Jia; Li, Tong; Su, Peng; Liu, Yunfei; Gu, Bingbing; Bao, Biqing; Wang, Lianhui

doi:10.1016/j.jconrel.2018.11.016

Cited by 35 publications

(31 citation statements)

References 35 publications

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“…[25] Thus, moisture-anda ir-stable ruthenium(II) complexes emerged as the catalysts of choice, with moste ffective catalysis accomplished by carboxylate assistance ( Table 1, entries 1-4). [26] Given the rather poor solubility of substrate 1a [1, 4b] and the aromatic character of PAH 3aa,w en ext explored various solvents (entries 4-9), with o-xylene being superior.C ontrole xperiments confirmed the essential role of carboxylate-assisted ruthenium(II) catalysis (entries [10][11]. The particularly challenging character of the twofold CÀH/NÀHa ctivation was reflected by palladium and iridium catalysts failing short in delivering the desired product 3aa (entries13a nd 14).…”

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confidence: 74%

π‐Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C−H/N−H Activation

Gońka

Yang

Steinbock

et al. 2019

Chemistry A European J

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The widespread applicationso fs ubstitutedd iketopyrrolopyrroles (DPPs) call for the development of efficient methods for their modular assembly.H erein,w e presentap-expansion strategy for polyaromatich ydrocarbons (PAHs) by CÀHa ctivationi nasustainable fashion. Thus, twofold CÀH/N-Ha ctivationsw ere accomplishedb y versatile ruthenium(II)carboxylatec atalysis,p roviding stepeconomical access to diversely decorated fluorogenic DPPs that was merged with late-stage palladium-catalyzed CÀHa rylation on the thus-assembled DPP motif.Since their first synthesis, [1] diketopyrrolopyrroles (DPPs) have attracted great attentionf rom researchers from various research arenas, including optoelectronic material sciences [2] and bioimaging. [3] These inconspicuous smallo rganic DPP molecules exhibit versatile propertiesr anging from low solubility, chemicalr esistance, outstanding stabilities and distinct colors, which render them excellent pigments. [4] N-Alkylationl eads to DPPs with improved solubilities,t he properties of which can be fine-tuned by the incorporationo fd ifferent aromatic motifs. [3] Due to their strong electron-withdrawing ability and opticalp roperties, DPPs are widely used as small molecules and conjugated semiconducting polymers in organic solarc ells (OSCs), [2a-e, g, 5] organic field-effect transistors (OFET), [2f, 6] organic photovoltaic cells (OPVs), [7] as well as fluorescentp robes, [3, 8] photocatalysts, [9] photosensitizers [10] or photothermal therapy agents, [11] promisinga nnihilatorm olecules, [12] self-assembled dyes, [13] and bioconjugated hybrids. [14] DPP derivatives with ah ighly decorated periphery as wella s DPP-based polymers are usually obtainedt hrough convention-

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confidence: 74%

π‐Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C−H/N−H Activation

Gońka

Yang

Steinbock

et al. 2019

Chemistry A European J

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“…The polymer nanoparticles proved their ability to A c c e p t e d m a n u s c r i p t be used for tumor treatment in vitro and in mice while allowing for the guidance of precise irradiation through photoacoustic imaging. 35 The quest for synergetic chemo and photothermal therapy also lead to the design of innovative core-shell nanostructures, made of a poly(lacticco-glycolic acid), PLGA, polymer surrounding liquid perfluorohexane and superparamagnetic oxide. The combination of those elements inside a single nanoplatform allowed for the precise monitoring of their location in vivo using bimodal ultrasound/photoacoustic (US/PA) imaging thus helping with the spatiotemporal activation of paclitaxel release and localized hyperthermia leading to severe reduction of mice tumor growth 36 Photothermal agent Ni8C 12 was synthesized according to the method previously described.…”

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confidence: 99%

Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

et al. 2019

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New thermosensitive liposomes with a phase transition at 42 °C, containing nickelbis(dithiolene) complexes as efficient and stable photothermal agents, have been formulated and characterized. These liposomes are highly stable and keep their contents at 37 °C for more than 30 days. On the contrary, the mild hyperthermia generated by the nickel-bis(dithiolene) complex under 940 nm NIR irradiation allows for the fine controlled release of the liposome contents, making such liposomes highly suitable for on-demand drug delivery in human body under NIR laser irradiation. These liposomes can also be directly used, as shown here, as nanoagents for photothermal therapy. In fact, strong cell death can be generated under laser irradiation in presence of these photothermally active nanocargos containing less than 10 %w/w

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“…This might limit the diversity of their possible postfunctionalization or conjugation reactions. Alternatively, synthetic polymers based on polyethylenimine, [24] polyethylene glycol, [25][26][27] polypyrrole, [28] poly(acrylic acid), [29][30][31] and polyglycerol [32] have been reported as scaffolds for PAI contrast agent delivery. The advantages of synthetic polymers are their controllable physicochemical (eg, size, shape, etc.)…”

Section: Introductionmentioning

confidence: 99%

Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics

Xiao

Gâteau

Silva

et al. 2021

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Photoacoustic imaging (PAI) is an emerging noninvasive and inexpensive bioimaging modality, which has stimulated a wide interest in recent years for cancer theranostics. Hybrid nano-and microgels have been designed as protective carriers to incorporate PAI contrast agents due to their biocompatibility and biodegradability, high loading capacity, versatile surface chemistry, and stimuliresponsive properties. These key features offer unprecedented opportunities for the design of innovative multifunctional cancer theranostic agents. This review focuses on the recent development of photoacoustic active nano-and microgels for biomedical applications in cancer theranostics and cancer hallmark imaging. The various chemical natures of gels and PAI contrast agents and the elaboration methods of hybrid matrices are summarized and discussed. Their applications in multimodal cancer theranostics and cancer hallmark imaging are presented, highlighting their merits and potential in treatment and diagnosis.

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pH/NIR-responsive semiconducting polymer nanoparticles for highly effective photoacoustic image guided chemo-photothermal synergistic therapy

Cited by 35 publications

References 35 publications

π‐Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C−H/N−H Activation

π‐Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C−H/N−H Activation

Liposomes Containing Nickel–Bis(dithiolene) Complexes for Photothermal Theranostics

Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics

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