Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics

Xiao, Yu; Gâteau, Jérôme; Silva, Amanda; Shi, Xiangyang; Gazeau, Florence; Mangeney, Claire; Luo, Yun

doi:10.1002/viw.20200176

Cited by 7 publications

(5 citation statements)

References 84 publications

(115 reference statements)

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“…It has been intensively proven that nanoformulations are capable of optimizing the pharmacokinetics of lactate metabolism‐targeting agents to significantly improve bioavailability and reduce toxic side effects, and realize the integration of tumor diagnosis and treatment. [ 194 ] More importantly, nanomaterials have exhibited several additional advantages that facilitate antitumor therapy based on lactate metabolic regulation, including the following. Most nanomaterials can readily codeliver two or more drugs.…”

Section: Discussionmentioning

confidence: 99%

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Cheng,

Shi,

et al. 2023

Advanced Science

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Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even under oxygen‐sufficient conditions. This metabolic alteration not only favors tumor cell progression and metastasis but also increases lactate accumulation in solid tumors. In addition to serving as a byproduct of glycolytic tumor cells, lactate also plays a central role in the construction of acidic and immunosuppressive tumor microenvironment, resulting in therapeutic tolerance. Recently, targeted drug delivery and inherent therapeutic properties of nanomaterials have attracted great attention, and research on modulating lactate metabolism based on nanomaterials to enhance antitumor therapy has exploded. In this review, the advanced tumor therapy strategies based on nanomaterials that interfere with lactate metabolism are discussed, including inhibiting lactate anabolism, promoting lactate catabolism, and disrupting the “lactate shuttle”. Furthermore, recent advances in combining lactate metabolism modulation with other therapies, including chemotherapy, immunotherapy, photothermal therapy, and reactive oxygen species‐related therapies, etc., which have achieved cooperatively enhanced therapeutic outcomes, are summarized. Finally, foreseeable challenges and prospective developments are also reviewed for the future development of this field.

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Section: Discussionmentioning

confidence: 99%

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Cheng,

Shi,

et al. 2023

Advanced Science

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“…In order to improve the delivery efficiency, residence time, and viability of CAR-T cells at tumor sites, more and more nanobiomaterials have been explored and applied, among which nanogels have been focused on due to their unique physical and chemical properties. [132][133][134] Recently, a polymer nanoparticle-based synthesized injectable hydrogel for the co-delivery of CAR-T cells and stimulatory cytokines was explored to improve immunotherapy of solid tumors [135] (Figure 18a-c). The average retention halflife of PNP-1-5 hydrogel after implantation was 8.9 ± 2.6 days (Figure 18d).…”

Section: Nanogel-delivered Car-t Cells Improve Immunotherapy Efficien...mentioning

confidence: 99%

Living Cell‐Derived Intelligent Nanobots for Precision Oncotherapy

Zhou,

Li,

Liu

et al. 2023

Adv Funct Materials

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The progress of precision oncology medicine is always limited by the tumor off‐targeting, the drug side effects, and the treatment inefficiency due to the complex and ever‐changing tumor microenvironment. Living cells, such as blood cells and immune cells, exhibit natural tumor tropism, controllable physicochemical modification, and excellent biocompatibility, which provide an advantageous pathway for innovative and efficient tumor suppression. Armed with nanoengineering techniques, artificial living cells harness their inherent biological properties to precisely identify and eradicate tumors, demonstrating broad biological application prospects and great transformational potential in personalized cancer therapy. Here, the recent advances of living cell‐based bionanobots including platelets, red blood cells, neutrophil, macrophage, and CAR‐T cells for cancer precision therapy and immune regulation are summarized, and the efficient anti‐tumor strategies for engineering living cell nanorobots to overcome complex biological barriers and immune suppression are also outlined (e.g., immunotherapy, sonodynamic therapy, chemo/radiotherapy, and phototherapy). In addition, the study discusses the advantages, limitations, and current challenges of artificial living cell‐based drug delivery systems, and provide perspectives on the future development of living cell‐mediated precision tumor nanomedicine.

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“…Other functional nanomaterials, including hydrogels, polymer, and iron oxides, have exhibited notable efficacy in cancer chemo‐immunotherapy, attributable to their distinct characteristics. [ 164 ] The hydrogels are 3D frameworks comprised of hydrophilic polymers, showing high drug loading, controllable drug release, and excellent biocompatibility and biodegradability. [ 165 ] For instance, a hydrogel‐based nanoplatform was demonstrated to achieve programmed delivery of Dox and CpG in the tumor tissues for regulating the ITME and boosting chemotherapy‐mediated ICD immune responses.…”

Section: Advanced Functional Materials For Enhanced Chemo‐immunotherapymentioning

confidence: 99%

Enhancing Cancer Chemo‐Immunotherapy: Innovative Approaches for Overcoming Immunosuppression by Functional Nanomaterials

Wang,

Li,

2023

Small Methods

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Chemotherapy is a critical modality in cancer therapy to combat malignant cell proliferation by directly attacking cancer cells and inducing immunogenic cell death, serving as a vital component of multi‐modal treatment strategies for enhanced therapeutic outcomes. However, chemotherapy may inadvertently contribute to the immunosuppression of the tumor microenvironment (TME), inducing the suppression of antitumor immune responses, which can ultimately affect therapeutic efficacy. Chemo‐immunotherapy, combining chemotherapy and immunotherapy in cancer treatment, has emerged as a ground‐breaking approach to target and eliminate malignant tumors and revolutionize the treatment landscape, offering promising, durable responses for various malignancies. Notably, functional nanomaterials have substantially contributed to chemo‐immunotherapy by co‐delivering chemo‐immunotherapeutic agents and modulating TME. In this review, recent advancements in chemo‐immunotherapy are thus summarized to enhance treatment effectiveness, achieved by reversing the immunosuppressive TME (ITME) through the exploitation of immunotherapeutic drugs, or immunoregulatory nanomaterials. The effects of two‐way immunomodulation and the causes of immunoaugmentation and suppression during chemotherapy are illustrated. The current strategies of chemo‐immunotherapy to surmount the ITME and the functional materials to target and regulate the ITME are discussed and compared. The perspective on tumor immunosuppression reversal strategy is finally proposed.

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Hybrid nano‐ and microgels doped with photoacoustic contrast agents for cancer theranostics

Cited by 7 publications

References 84 publications

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Living Cell‐Derived Intelligent Nanobots for Precision Oncotherapy

Enhancing Cancer Chemo‐Immunotherapy: Innovative Approaches for Overcoming Immunosuppression by Functional Nanomaterials

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