pH in the Bacteria-Contaminated Wound and Its Impact on Clostridium histolyticum Collagenase Activity

Shi, Lei; Ramsay, Sarah; Ermis, Ryan; Carson, Dennis

doi:10.1097/won.0b013e31822ad034

Cited by 48 publications

(31 citation statements)

References 25 publications

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“…Upon infection, bacteria seek to increase the wound pH to create an environment that is more accommodating to their growth. [ 28,29 ] It has been proposed that this increase in pH could be a diagnostic handle through which to identify the onset of infection [ 30 ] and there is an increasing effort to develop disposable pH sensors that could be applied to wound monitoring. Redrawn from ref.…”

Section: Electrochemical Solutionsmentioning

confidence: 99%

New Developments in Smart Bandage Technologies for Wound Diagnostics

et al. 2016

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The pH of wound fluid has long been recognized as an important diagnostic for assessing wound condition, but as yet there are few technological options available to the clinician. The availability of sensors that can measure wound pH, either in the clinic or at home could significantly improve clinical outcome - particularly in the early identification of complications such as infection. New material designs and electrochemical research strategies that are being targeted at wound diagnostics are identified and a critical overview of emerging research that could be pivotal in setting the direction for future devices is provided.

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Section: Electrochemical Solutionsmentioning

confidence: 99%

New Developments in Smart Bandage Technologies for Wound Diagnostics

et al. 2016

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“…In the case of acute wounds, pH changes through the 4-fold steps of wound healing, including haemostasis, inammation, proliferation and remodelling, which is considered a simpler route compared to the healing of chronic wounds. 5 Thus far, different methods have been reported for measuring the pH, including colorimetric methods, 6 electromechanical 7 and electrochemicalbased techniques. 8 All of these methods are useful but they have some disadvantages, such as sophisticated technologies, high cost production and difficult usage.…”

Section: Introductionmentioning

confidence: 99%

Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

2017

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Monitoring the pH of wounds has been recognized as an essential diagnosis factor during the healing process. This study presents a novel chitosan-carbon dots nanocomposite with dual applications as an antibacterial and pH-sensitive nano-agent for enhancing wound healing and monitoring the pH at the same time. The carbon dots (CDs) were synthesized using ammonium hydrogen citrate under Furthermore, the optimized ratio of CDs/chitosan nanocomposite was used as an antibacterial wound healing bandage and in vivo experiments were carried out on three groups of rats. The results showed that the CDs/chitosan nanocomposite not only possessed high pH sensitivity, but could also improve the wound healing process due to its antibacterial properties.

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“…Enzymatic debridement is an active and selective method of wound debridement that uses naturally occurring proteolytic enzymes for eliminating barriers to the epithelialization process . Enzymatic debridement with clostridial collagenase ointment (CCO) (derived from Clostridium histolyticum ) has been used as a method of wound debridement for more than 50 years . Collagenase is an enzyme that effectively removes detritus without harming healthy tissue, thereby contributing to the formation of granulation tissue and subsequent epithelialization of dermal ulcers .…”

mentioning

confidence: 99%

Treating pressure ulcers with clostridial collagenase ointment: Results from the US Wound Registry

Carter

Gilligan

Waycaster

et al. 2016

Wound Repair Regeneration

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We assessed the clinical effectiveness of clostridial collagenase ointment (CCO) as an adjunct to selective debridement compared with selective debridement alone for the management of stage IV pressure ulcers (PU) in the hospital outpatient department setting. Outcome data were derived from retrospective de-identified electronic medical records from 2007 to 2013 using the US Wound Registry. A propensity score method was used to adjust for selection bias and to test for treatment effect between PU treated with CCO plus selective debridement vs. selective debridement alone. A total of 337 CCO and 336 non-CCO stage IV PU were identified. The proportion of wounds closed at any time (e.g., at 1 or 2 years) was two times greater for stage IV PU treated with CCO compared with those not treated with CCO. Kaplan-Meier analysis showed that time to wound closure at 1 year was significantly faster for PU treated with CCO vs. PU not treated with CCO. Among those with five or more CCO applications or selective debridement treatments, significantly more CCO-treated PU were closed at 1 or 2 years than non-CCO-treated PU. CCO as an adjunct to selective debridement improved clinical outcomes and provided faster rates of closure of stage IV PU relative to selective debridement alone.

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pH in the Bacteria-Contaminated Wound and Its Impact on Clostridium histolyticum Collagenase Activity

Cited by 48 publications

References 25 publications

New Developments in Smart Bandage Technologies for Wound Diagnostics

New Developments in Smart Bandage Technologies for Wound Diagnostics

Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

Treating pressure ulcers with clostridial collagenase ointment: Results from the US Wound Registry

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