Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

Abstract

Monitoring the pH of wounds has been recognized as an essential diagnosis factor during the healing process. This study presents a novel chitosan-carbon dots nanocomposite with dual applications as an antibacterial and pH-sensitive nano-agent for enhancing wound healing and monitoring the pH at the same time. The carbon dots (CDs) were synthesized using ammonium hydrogen citrate under Furthermore, the optimized ratio of CDs/chitosan nanocomposite was used as an antibacterial wound healing bandage and in vivo experiments were carried out on three groups of rats. The results showed that the CDs/chitosan nanocomposite not only possessed high pH sensitivity, but could also improve the wound healing process due to its antibacterial properties.

Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery

“…CQDs was synthesized and characterized as same as the procedure described in our previous report. 32 Briey, ammonium hydrogen citrate (1 g) was added to 30 mL of DI water under vigorous stirring for 15 minutes. The resulting solution was transferred to a 100 mL hydrothermal autoclave reactor and heated up to 180 C for 12 h. Subsequently, the reactor was cooled down to room temperature.…”

“…Cell proliferation of each sample was determined aer 5 days using WST and live/dead assay. 32,37 2.10. Characterization…”

“…At such a size scale, CQDs experience the domination of quantum connement effect, which leads to the formation of electron-hole pairs with the dimensions smaller than the exciton Bohr radius. [32][33][34] CQDs with outstanding features such as excellent optical properties, biocompatibility, and facile surface modication, have drawn attention. 35 In this study, solid/oil/water (s-o-w), microuidic platform was developed for encapsulation of PEGylated VEGF in PLGA -CQDs microspheres.…”

In vitro effect of graphene structures as an osteoinductive factor in bone tissue engineering: A systematic review

“…Polymer-based materials are widely used for biomedical applications since they are easily shaped and have adjustable chemical properties. [137][138][139][140] However, some of the polymeric materials used in tissue regeneration have to simulate inflammatory reactions, and their degradation might simulate an autocatalytic ester breakdown than can decrease the pH in the microenvironment, causing problems for cell viability and differentiation. 141 In order to overcome these limitations, graphene and its derivatives can be incorporated into polymers through different methods to produce composites exhibiting synergistic effects over the two individual components with improved properties.…”

Preparation of Light‐Responsive Aliphatic Polycarbonate via Versatile Polycondensation for Controlled Degradation

“…In the past decades, synthetic smart polymer‐based biomaterials have attracted significant attention in fields of biomedical and pharmaceutical applications, such as drug and gene delivery, tissue engineering, and tissue adhesives . Structure, polarity, or solubility of such biomaterials can be significantly changed in response to internal (pH, redox gradients, enzymes) or external (temperature, light irradiation, magnetic, or electrical fields) stimuli, thereby enabling more efficient and controlled drug release at targeted sites and reducing injuries to healthy tissues or organs .…”