pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix

Kim, Sanghoon; Stébé, Marie‐José; Blin, Jean-Luc; Pasc, Andreea

doi:10.1039/c4tb01133c

Cited by 65 publications

(36 citation statements)

References 64 publications

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“…Unlike disaccharides, 8 peptides, 9 and inorganic NPs 10 that require further polymeric or liposomal modifications to serve as a drug delivery system (DDS), the amphiphilic block copolymers can self-assemble into core-shell NPs in aqueous solution without further modification. This combined with their ability to encapsulate a wide range of active compounds offers promise in the design of NPs for effective targeted delivery.…”

Section: Introductionmentioning

confidence: 99%

Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

et al. 2015

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Histamine functionalized block copolymers based on poly(allyl glycidyl ether)-b-poly(ethylene oxide) (PAGE-b-PEO) were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry. At neutral pH, the histamine units are uncharged and hydrophobic, while in acidic environments, such as in the endosome, lysosomes, or extracellular sites of tumours, the histamine groups are positively charged and hydrophilic. pH responsible polymer drug delivery systems is a promising route to site specific delivery of drugs and offers the potential to avoid side effects of systemic treatment. Our detailed in vitro experiments of the efficacy of drug delivery and the intracellular localization characteristics of this library of NPs in 2D and 3D cultures of breast cancer revealed that the 50% histamine-modified polymer loaded with DOX exhibited rapid accumulation in the nucleus of free DOX within 2 h. Confocal studies showed enhanced mitochondrial localization and lysosomal escape when compared to controls. From these combined studies, it was shown that by accurately tuning the structure of the initial block copolymers, the resulting self-assembled NPs can be designed to exploit histamine as an endosomal escape trigger and the octyl/benzyl units give rise to a hydrophobic core resulting in highly efficacious drug delivery systems (DDS) with control over intracellular localization. Optimization and rational control of the intracellular localization of both DDS and the parent drug can give nanomedicines a substantial increase in efficacy and should be explored in future studies.

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Section: Introductionmentioning

confidence: 99%

Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

et al. 2015

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“…In the hybrid, as synthesized materials, it can also noticed that the characteristic repeat distance of the solid lipid q value. 28 Therefore, it seems that CTAF is not intercalating the hexylpalmitate in the core of the SLNs.…”

Section: Synthesis Of Fe2o3@meso-macroporous Silicamentioning

confidence: 99%

Metallo-Solid Lipid Nanoparticles as Colloidal Tools for Meso–Macroporous Supported Catalysts

et al. 2015

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Meso-macroporous silica containing iron oxide nanoparticles (15-20 nm) was synthesized by formulating solid lipid nanoparticles and metallosurfactant as both template and metal source. Due to the high active surface area of the catalyst, the material exhibits an excellent performance in a Fenton-like reaction for methylene blue (MB) degradation, even at low amount of iron oxide (5% TOC after 14h).2

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“…Compared to the previous studies, increasing number of homogenization cycles while maintaining the same pressure led to only a small decrease in the diameter. The results significantly indicated that The FTIR spectrum of DLGL, ceramide-2 and the mixture of them at a 1:1 ratio DLGL effectively combined with ceramide-2 to form a relatively stable structure [29]. Therefore, a homogenization pressure of 30 MPa and three processing cycles were used to prepare ceramide-2 nanoemulsions.…”

Section: Effects Of Homogenization Pressure and Number Of Cycles On Tmentioning

confidence: 99%

Nanoemulsification of Ceramide‐2 by Sodium Dilauramidoglutamide Lysine, a Novel Peptide‐Based Gemini Surfactant

Tian

Guo²,

Yang

et al. 2016

J Surfact & Detergents

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A novel peptide-based gemini surfactant, namely, sodium dilauramidoglutamide lysine (DLGL) was employed to fabricate a stable nanoemulsion system for the delivery of hydrophobic bioactive ceramide-2 molecules. The phase properties and morphology and stability of the nanoemulsion were investigated by focusing on the interaction between DLGL and ceramide-2 molecules. The investigation of the phase properties of the mixture of DLGL and ceramide-2 by X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy revealed remarkable reduction in the crystallinity of ceramide-2 due to the presence of DLGL. The spherical shape and nanometer size of nanoemulsions emulsified by DLGL were characterized by scanning electron microscopy and transmission electron microscopy. The nanoemulsions prepared using DLGL exhibited significant improvement in the dispersion stability without any significant changes in the particle sizes even after storing them for a month at 50°C. The results indicated that DLGL readily associated with ceramide-2 to form a relatively stable structure. The steric hindrance of DLGL and molecular rearrangement of DLGL and ceramide-2 attributed to a break in the continuity of the molecular assembly of ceramide-2, which hampered its crystallinity.

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pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix

Cited by 65 publications

References 64 publications

Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

Metallo-Solid Lipid Nanoparticles as Colloidal Tools for Meso–Macroporous Supported Catalysts

Nanoemulsification of Ceramide‐2 by Sodium Dilauramidoglutamide Lysine, a Novel Peptide‐Based Gemini Surfactant

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