pH and redox dual stimuli-responsive injectable hydrogels based on carboxymethyl cellulose derivatives

Shen, Yue-Qin; Li, Xian; Huang, Yawen; Chang, Guanjun; Cao, Ke; Yang, Junxiao; Zhang, Renyi; Sheng, Xueying; Yu, Xu

doi:10.1007/s13233-016-4077-6

Cited by 39 publications

(13 citation statements)

References 38 publications

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“…As mentioned in Section , in recent years, hydrogels have attracted increasing interest due to their broad range of applications in areas such as tissue engineering, drug delivery systems, sensors, and implant materials . Particularly, redox‐responsive hydrogels, which undergo reversible volume phase‐transition or sol–gel phase‐transition in response to the reduction potential, have great potential in biomedical and biotechnological applications …”

Section: Applicationsmentioning

confidence: 99%

Sulfur Chemistry in Polymer and Materials Science

Mutlu

Ceper

et al. 2018

Macromol. Rapid Commun.

256

220

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/marc.201800650. ChemistryBefore moving to the recent advances within the last 5 years in the diverse applications of sulfur chemistry in polymer and Sulfur-Containing PolymersSulfur and its functional groups are major players in an area of exciting research taking place in modern polymer and materials science, both in academia and industry. In fact, manifold sulfur-based reactions that are both exceptionally versatile as well as tremendously useful have been implemented, and further utilized for the design and preparation of polymeric materials that lead to a plethora of applications ranging from medicine to optics and nanotechnology to separation science. Hence, within this review, an overview of strategies and developments used over the last 5 years to reinforce the importance of the sulfur functional group in modern polymer and materials science is presented. In particular, many important references in the primary literature of sulfur chemistry are referred to, including thiol-ene, thiol-yne, thiol-Michael addition, disulfide cross-linking, and thiol-disulfide exchange, among others, by explaining and illustrating the important principles. Last but not least, the grand aim to underpin the importance of sulfur in modern polymer and materials science is achieved by presenting selected examples in diverse fields and postulating the respective potential for real-world applications. he is now a full professor at KIT.sulfur atoms, and tetraphenylethene-bearing di(alkyl bromide) (Scheme 3). The yield of the polymerization was dependent on the di(alkyl bromide) monomer; the longer spacer between the aromatic moiety and the reactive bromide end groups Scheme 1. The discussion henceforth focuses on the synthesis of polymers possessing the depicted sulfur functional groups. Scheme 2.Representative examples of polythioethers prepared via A) the nucleophilic substitution reaction between an electrophilic dihalide with nucleophilic derivatives of dithiols under alkaline conditions; B) the thiol-ene/yne addition reaction between AA and BB type monomers (i.e., dithiols and dienes/diynes); and C) radical or ionic ring-opening of sulfurcontaining strained rings.Scheme 3. The thiol-bromo polymerization of conformationally fixed monomers to provide multifunctional polymers. [19] Macromol. Rapid Commun. 2019, 40, 1800650 Scheme 4. The regioselective selective nucleophilic aromatic substitution between thiol and fluorinated aromatic compounds, the para-fluorothiol reaction (PFTR).Scheme 5. Synthesis of a linear polymer via PFTR-reaction. [21]

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Section: Applicationsmentioning

confidence: 99%

Sulfur Chemistry in Polymer and Materials Science

Mutlu

Ceper

et al. 2018

Macromol. Rapid Commun.

256

220

View full text Add to dashboard Cite

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“…So far, various types of hydrogels with adjustable modulus, controllable degradation, and designable chemical compositions have been designed to simulate the microenvironment in vivo. Considering that the environment in vivo is not static and contains many different gradients, stimulusresponsive hydrogels triggered by light irradiation [18], pH change [25], and enzyme catalyzation [26] have been developed as well.…”

Section: Introductionmentioning

confidence: 99%

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

et al. 2020

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Cell migration plays a pivotal role in many pathological and physiological processes. So far, most of the studies have been focused on 2-dimensional cell adhesion and migration. Herein, the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid (HA-MA) and fibrinogen (Fg) with different ratios were studied. The Fg could be released to the medium gradually along with time prolongation, achieving the dynamic change of hydrogel structures and properties. Three types of cell spheroids, i.e., endothelial cell (EC), smooth muscle cell (SMC), and EC-SMC spheroids, were prepared with 10,000 cells in each, whose diameters were about 343, 108, and 224 μm, respectively. The composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell spheroids. The ECs-SMCs migrated longest up to 3200 μm at day 14, whereas the SMC spheroids migrated slowest with a distance of only ~400 μm at the same period of time. The addition of free RGD or anti-CD44 could significantly reduce the migration distance, revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal dependent. Moreover, addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate, demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell migration. RT-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis, and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids, suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions.

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“…Gelling time was noted down for sol to gel conversion of the solution immediately after addition of glutaraldehyde. The nal sample was washed with double distilled water to remove unreacted impurities (Shen et al, 2016;Maia, Carvalho, Coelho, Simões & Gil, 2016;Pettignano et al, 2017).…”

Section: Synthetic Route For Self-healing Hydrogelmentioning

confidence: 99%

“…Finally a complex structure with crosslinks is formed in the nal hydrogel network (Scheme 2). Hence, the major bonding used in the network includes H-bonding and dynamic imide linkages (Shen et al, 2016;Maia, Carvalho, Coelho, Simões & Gil, 2016;Pettignano et al, 2017;Balakrishnan, Joshi & Banerjee, 2013;OU & BO, 2017).…”

Section: Reaction Mechanismmentioning

confidence: 99%

Borax assisted synthesis of dialdehyde Carboxymethyl cellulose-Dextrin/Gelatin based biocompatible self-healing hydrogel

Sharma¹,

Bhalla²,

Kaith³

et al. 2021

Preprint

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The hydrogels with self-healing properties have high potential applications in the biomedical field. Generally, the imine bonds are used as the dynamic covalent bonding in the self-healing hydrogels and hydrogen bonding is used for providing additional strength to self-healing hydrogels. In the presented work, Gelatin, dialdehyde dextrin, and dialdehyde Carboxymethyl cellulose (CMC) based hydrogels were prepared which are biocompatible and biodegradable and hence, can be used in biomedical field. Borax and glutaraldehyde were used as binding agent and cross-linker, respectively. The dynamic imide bond formed between gelatin-dialdehyde dextrin, gelatin-dialdehyde CMC, and gelatin-glutaraldehyde were responsible for self-healing ability of the prepared hydrogel. The rheological studies were also carried out which showed that as a consequence of lower viscosity the hydrogels can show injectable properties. The sample was also found to be blood compatible, which further highlights its biomedical importance.

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pH and redox dual stimuli-responsive injectable hydrogels based on carboxymethyl cellulose derivatives

Cited by 39 publications

References 38 publications

Sulfur Chemistry in Polymer and Materials Science

Sulfur Chemistry in Polymer and Materials Science

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

Borax assisted synthesis of dialdehyde Carboxymethyl cellulose-Dextrin/Gelatin based biocompatible self-healing hydrogel

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