pH- and glutathione-responsive release of curcumin from mesoporous silica nanoparticles coated using tannic acid–Fe(<scp>iii</scp>) complex

Kim, Sanghoon; Philippot, Stéphanie; Fontanay, Stéphane; Duval, Raphaël E.; Lamouroux, Emmanuel; Canilho, Nadia; Pasc, Andreea

doi:10.1039/c5ra16004a

Cited by 77 publications

(38 citation statements)

References 60 publications

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“…The average particle size of MCM‐41 is 263.4 nm. Based on data, these results demonstrate that textural properties for MCM‐41 are agreement with previous published results …”

Section: Resultssupporting

confidence: 92%

Chitosan/Polyvinylpyrrolidone/MCM‐41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties

et al. 2018

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The aim of this study is to characterize and investigate the effects of the Mobil Composition of Matter No. 41 (MCM-41) concentrations (0.5, 1, 3, 5, and 10 wt%) on structural, thermal, wettability, water content, oxygen (O 2 ) permeability, and swelling properties as well as morphological characteristics of chitosan/polyvinylpyrrolidone/MCM-41 (CH/PVP/MCM-41) composite hydrogel films. In addition, hydrolytic degradability, optic transmittance, and antibacterial properties of composite hydrogels films are determined as in vitro. With increasing of MCM-41 content, the composite hydrogels showed higher thermal stability, as expected. The morphologic properties of the composite hydrogel films are studied using scanning electron microscope (SEM) technique that provide evidence for good miscibility of CH, PVP, and MCM-41. The swelling and water-absorbing properties of the composite hydrogel films are significantly improved because of enhanced hydrophilic profile. Furthermore, the antimicrobial properties of the prepared composite hydrogel films are studied against Bacillus subtilis, Escherichia coli, and Candida albicans yeast. The results showed excellent antibacterial behavior of the composite hydrogel films. The study clearly demonstrates that the prepared CH/PVP/MCM-41 composite hydrogel films may be used as a promising candidate material in various fields such as drug delivery, wound healing material, and adsorbent materials.

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“…The average particle size of MCM‐41 is 263.4 nm. Based on data, these results demonstrate that textural properties for MCM‐41 are agreement with previous published results …”

Section: Resultssupporting

confidence: 92%

Chitosan/Polyvinylpyrrolidone/MCM‐41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties

et al. 2018

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“…Furthermore the zeta potential of the Curc-MSNP decreased from -23.9 ± 0.4 mV to -16.9 ± 0.9 mV (P ≤ 0.01) ( Figure 6B). This increase in particle size and PDI has been previously reported after loading curcumin in their mesoporous nanoparticles 51,79 . Furthermore the decrease in zeta potential following loading has previously been reported, however the polarity of the resultant charge is a function of the pH of the media that the zeta potential is measured in, with reports that a lower pH media often leads to more positive zeta potential with loading [82][83][84][85] .…”

Section: Phytochemical Loading Into Msnpsupporting

confidence: 82%

“…Furthermore, mesoporous silica nanoparticles have recently been used to demonstrate loading and release of curcumin 51 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

Lungare

Hallam

Badhan

2016

International Journal of Pharmaceutics

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Central nervous system (CNS) drug delivery is often hampered due to the insidious nature of the blood-brain barrier (BBB). Nose-to-brain delivery via olfactory pathways have become a target of attention for drug delivery due to bypassing of the BBB. The antioxidant properties of phytochemicals make them promising as CNS active agents but possess poor water solubility and limited BBB penetration. The primary aim of this study was the development of mesoporous silica nanoparticles (MSNs) loaded with the poorly water-soluble phytochemicals curcumin and chrysin which could be utilised for nose-to-brain delivery. We formulated spherical MSNP using a templating approach resulting in ∼220nm particles with a high surface porosity. Curcumin and chrysin were successfully loaded into MSNP and confirmed through Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC approaches with a loading of 11-14% for curcumin and chrysin. Release was pH dependant with curcumin demonstrating increased chemical stability at a lower pH (5.5) with a release of 53.2%±2.2% over 24h and 9.4±0.6% for chrysin. MSNP were demonstrated to be non-toxic to olfactory neuroblastoma cells OBGF400, with chrysin (100μM) demonstrating a decrease in cell viability to 58.2±8.5% and curcumin an IC of 33±0.18μM. Furthermore confocal microscopy demonstrated nanoparticles of <500nm were able to accumulate within cells with FITC-loaded MSNP showing membrane localised and cytoplasmic accumulation following a 2h incubation. MSNP are useful carriers for poorly soluble phytochemicals and provide a novel vehicle to target and deliver drugs into the CNS and bypass the BBB through olfactory drug delivery.

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“…Owing to their unique advantages including well-defined morphology, uniform size, controllable structure, super high specific pore volume, tunable pore size, easily modified surface, high drug-loading capacity, and excellent biocompatibility, mesoporous silica nanoparticles (MSNs) have attracted increasing interest in biomedical applications in the recent decades, especially in controlled drug delivery system (Berger et al, 2016;Chen et al, 2013a;Chen et al, 2014;Chen et al, 2013b;Chin et al, 2014;Ge et al, 2015;Jia et al, 2015;Kim et al, 2015;Knežević et al, 2013;Li et al, 2011;Mamaeva et al, 2013;Niu et al, 2014;Tang and Cheng, 2013;Tao, 2014;von Haartman et al, 2013;. However, the simplex structure of MSNs is barely able to meet the demands of drug release in complicated in vivo environment.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical mesoporous silica nanoparticles for tailorable drug release

Xiao

et al. 2016

International Journal of Pharmaceutics

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pH- and glutathione-responsive release of curcumin from mesoporous silica nanoparticles coated using tannic acid–Fe(iii) complex

Abstract: A novel pH- and glutathione-responsive drug delivery system has been developed by deposition of tannic acid (TA)–Fe(iii) complex on the surface of mesoporous silica nanoparticles (MSN).

Cited by 77 publications

References 60 publications

Chitosan/Polyvinylpyrrolidone/MCM‐41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties

Chitosan/Polyvinylpyrrolidone/MCM‐41 Composite Hydrogel Films: Structural, Thermal, Surface, and Antibacterial Properties

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

Hierarchical mesoporous silica nanoparticles for tailorable drug release

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