PGE1 compared to PGE2/PGF2α ratio as a marker for seminal fluid contamination of urine in studies of renal prostaglandin biosynthesis

Ferretti, Aldo; Judd, Joseph T.

doi:10.1016/0952-3278(91)90143-s

Cited by 7 publications

(1 citation statement)

References 23 publications

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“…Whereas the primary prostanoids (PGE.,, PGIJ) in urine are predominantly synthesized in the kidney, their metabolites represent total body and in part renal production.33'47 Occasional and unpredictable contamination of urine with seminal fluid limits the usefulness of the primary prostaglandin PGE, as a marker of renal prostaglandin biosynthesis in male subjects, explaining extremely high excretion rates of PGE2 in some volunteers. 48 Therefore, urinary excretion of PGE, was not reduced significantly by diclofenac or celecoxib, although medians were lowered after 15 days of treatment to 50% of baseline values. With both NSAIDs.…”

Section: Discussionmentioning

confidence: 78%

Effects of Celecoxib and Diclofenac on Blood Pressure, Renal Function, and Vasoactive Prostanoids in Young and Elderly Subjects

Dilger¹,

Herrlinger²,

Peters³

et al. 2002

Journal of Clinical Pharmacology

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Cyclooxygenase (COX) inhibitors are among the most widely used drugs, especially in the elderly. It has been claimed that the new COX-2 inhibitors offer advantages in terms of drug safety. To test this hypothesis, the authors compared in a double-blind, randomized trial the effects of celecoxib (200 mg bid) and diclofenac (75 mg bid) on blood pressure and renal function in two groups (each n = 12) of young (mean age = 32 years) and elderly (mean age = 68 years) normotensive subjects. Changes from baseline in the 24-hour blood pressure profiles, parameters of the renin-angiotensin-aldosterone system, inulin clearance, urinary marker proteins, and eicosanoid excretion were monitored during the treatment period of 2 weeks. Comparison between celecoxib and diclofenac showed no significant difference in minor alterations of blood pressure. During daytime, there was a trend to elevation of mean arterial blood pressure (mmHg) by celecoxib in the elderly of 2.8 (95 % confidence interval [CI) = -2.5 to 8.2) in comparison with the young subjects of -1.3 (95% CI= -3.7 to 1.0); there was also a trend to elevation of mean arterial blood pressure by diclofenac in the elderly of 4.1 (95% CI= -1.2 to 9.4) in comparison with the young subjects of 0.4 (95% CI= -2.4 to 3.2). In both populations, the authors found no significant drug effects on the parameters of the renin-angiotensin-aldosterone system, inulin clearance, and urinary marker proteins. As expected, diclofenac reduced excretion of allprostanoids, whereas celecoxib did not affect production of TxB2 and its metabolites. Neither in young nor in elderly normotensive subjects were blood pressure and renal function significantly affected by a short-term treatment with standard doses of celecoxib and diclofenac. Therefore, normal aging appears not to represent a special risk factor in therapy with these two agents.

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Section: Discussionmentioning

confidence: 78%

Effects of Celecoxib and Diclofenac on Blood Pressure, Renal Function, and Vasoactive Prostanoids in Young and Elderly Subjects

Dilger¹,

Herrlinger²,

Peters³

et al. 2002

Journal of Clinical Pharmacology

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Liquid chromatography and radioimmunoassay method for the determination of prostaglandins E1 and E2 in rat embryo incubates

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Roselló‐Catafau

Closa

et al. 1993

Journal of Chromatography A

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Effect of n-3 Fatty Acid Supplementation on Urinary Risk Factors for Calcium Oxalate Stone Formation

et al. 2011

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Results show that 30-day n-3 fatty acid supplementation effectively decreases urinary oxalate excretion and the risk of calcium oxalate crystallization. The mechanism of the physiological effect may be decreased cellular oxalic acid exchange attributable to an altered fatty acid pattern of membrane phospholipids with concomitant changes in oxalate transporter activity. Calcium oxalate stone formers may benefit from long-term n-3 fatty acid supplementation.

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PGE1 compared to PGE2/PGF2α ratio as a marker for seminal fluid contamination of urine in studies of renal prostaglandin biosynthesis

Cited by 7 publications

References 23 publications

Effects of Celecoxib and Diclofenac on Blood Pressure, Renal Function, and Vasoactive Prostanoids in Young and Elderly Subjects

Effects of Celecoxib and Diclofenac on Blood Pressure, Renal Function, and Vasoactive Prostanoids in Young and Elderly Subjects

Liquid chromatography and radioimmunoassay method for the determination of prostaglandins E1 and E2 in rat embryo incubates

Effect of n-3 Fatty Acid Supplementation on Urinary Risk Factors for Calcium Oxalate Stone Formation

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