1991
DOI: 10.1016/0952-3278(91)90143-s
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PGE1 compared to PGE2/PGF2α ratio as a marker for seminal fluid contamination of urine in studies of renal prostaglandin biosynthesis

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Cited by 7 publications
(1 citation statement)
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“…Whereas the primary prostanoids (PGE.,, PGIJ) in urine are predominantly synthesized in the kidney, their metabolites represent total body and in part renal production.33'47 Occasional and unpredictable contamination of urine with seminal fluid limits the usefulness of the primary prostaglandin PGE, as a marker of renal prostaglandin biosynthesis in male subjects, explaining extremely high excretion rates of PGE2 in some volunteers. 48 Therefore, urinary excretion of PGE, was not reduced significantly by diclofenac or celecoxib, although medians were lowered after 15 days of treatment to 50% of baseline values. With both NSAIDs.…”
Section: Discussionmentioning
confidence: 78%
“…Whereas the primary prostanoids (PGE.,, PGIJ) in urine are predominantly synthesized in the kidney, their metabolites represent total body and in part renal production.33'47 Occasional and unpredictable contamination of urine with seminal fluid limits the usefulness of the primary prostaglandin PGE, as a marker of renal prostaglandin biosynthesis in male subjects, explaining extremely high excretion rates of PGE2 in some volunteers. 48 Therefore, urinary excretion of PGE, was not reduced significantly by diclofenac or celecoxib, although medians were lowered after 15 days of treatment to 50% of baseline values. With both NSAIDs.…”
Section: Discussionmentioning
confidence: 78%