2011
DOI: 10.1016/j.juro.2010.09.074
|View full text |Cite
|
Sign up to set email alerts
|

Effect of n-3 Fatty Acid Supplementation on Urinary Risk Factors for Calcium Oxalate Stone Formation

Abstract: Results show that 30-day n-3 fatty acid supplementation effectively decreases urinary oxalate excretion and the risk of calcium oxalate crystallization. The mechanism of the physiological effect may be decreased cellular oxalic acid exchange attributable to an altered fatty acid pattern of membrane phospholipids with concomitant changes in oxalate transporter activity. Calcium oxalate stone formers may benefit from long-term n-3 fatty acid supplementation.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
27
0
2

Year Published

2011
2011
2014
2014

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 38 publications
(30 citation statements)
references
References 27 publications
0
27
0
2
Order By: Relevance
“…Again, dietary components were not strictly controlled in this study. Siener et al 9 studied 15 healthy subjects who consumed a standardized diet for 5 days, a self-selected diet for 20 days, and a standardized diet again for 5 days. Each participant took 900-mg EPA and 600-mg DHA daily for the last 25 days of the study.…”
Section: Commentmentioning
confidence: 99%
See 3 more Smart Citations
“…Again, dietary components were not strictly controlled in this study. Siener et al 9 studied 15 healthy subjects who consumed a standardized diet for 5 days, a self-selected diet for 20 days, and a standardized diet again for 5 days. Each participant took 900-mg EPA and 600-mg DHA daily for the last 25 days of the study.…”
Section: Commentmentioning
confidence: 99%
“…It could be that the mechanisms proposed by Siener et al, alterations in renal secretion of oxalate or a reduction in net gastrointestinal oxalate absorption, are valid. 9 Perhaps, the responses would be different in a diseased cohort. Our subjects may have had low levels of oxidative stress.…”
Section: Commentmentioning
confidence: 99%
See 2 more Smart Citations
“…These could also significantly reduce inflammation, fibrosis and oxidative stress following renal injury (Soumura et al, 2010;Peake et al, 2011). Moreover, fish oil supplements (900 mg of EPA and 600 mg of DHA/day for 1 month) may decrease urinary oxalate excretion and the risk of calcium oxalate crystallization attributable to an altered oxalate transporter activity (Siener et al, 2011). Chronic hemodialysis patients reportedly have significantly low concentrations of EPA and DHA in the plasma and cell membranes (Saifullah et al, 2007;Nakamura et al, 2008;Madsen et al, 2011).…”
Section: Other Nutrients (Substrates)mentioning
confidence: 99%