PET/CT with Sodium ¹⁸F-Fluoride for Management of Patients with Prostate Cancer

The potential of 223Ra and 18F-fluoride imaging to predict bone lesion response to treatment with 223Ra-dichloride in castration-resistant prostate cancer

“…18 F-fluoride localises to the inorganic part of the bone, particularly in areas of osteoblastic activity, and has been used extensively for PET imaging of metastatic bone disease. Several studies have demonstrated superior sensitivity and specificity of 18 F-fluoride imaging in comparison to conventional bone scintigraphy [14,15]. Fluoride ions are incorporated into the hydroxyapatite crystal structure of the bone by substitution for hydroxyl (OH) ions.…”

18F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

“…A major diagnostic application of 18 F-NaF PET scan that has been explored is its use in the detection of osseous lesions of metastatic cancers such as breast, prostate, and lung cancers. With growing research on the relevance of 18 F-NaF PET in the field of oncology, it has been proven to be an important tool when compared with traditional modalities such as planar and SPECT 99m Tc-MDP bone scintigraphy in assessing the extent of metastatic burden for a variety of malignancies (9)(10)(11)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). There is evidence that 18 F-NaF PET can be positive earlier than 99m Tc-MDP whole-body bone scanning in small lytic or blastic metastases (33).…”

Initial prostate cancer diagnosis and disease staging—the role of choline-PET–CT

“…In particular, increasing evidence exists regarding the influence of choline-PET-CT in changing the management of patients, either as a first imaging study or as a secondary study, after bone scintigraphy. 4,[52][53][54][55] Beheshti and colleagues 56 evaluated 70 men with biopsyproven prostate cancer who underwent 18 F-choline-PET-CT for either preoperative staging (n = 32) or followup evaluation (n = 38). The authors showed sensitivity, specificity, and accuracy of 79%, 97%, and 84%, respectively, for bone metastases detection.…”