Pesticide concentrations in maternal and umbilical cord sera and their relation to birth outcomes in a population of pregnant women and newborns in New Jersey

Barr, Dana Boyd; Ananth, Cande V.; Yan, Xiaoyong; Lashley, Susan; Smulian, John C.; Ledoux, Thomas A.; Hore, Paromita; Robson, Mark G.

doi:10.1016/j.scitotenv.2009.10.007

Cited by 91 publications

(91 citation statements)

References 25 publications

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“…Many studies have used very crude exposure indicators, such as history of residence in agricultural areas or paternal/maternal farming occupation during pregnancy or early childhood 25. Pesticide biomarkers at the time of birth, specifically residues in the umbilical cord or meconium,26 reflect recent exposures or exposures to highly persistent pesticides, but do not cover all prenatal pesticide exposures of concern. Recent birth cohorts prospectively follow-up children from the prenatal period to the years after birth, through the mothers' urine levels during pregnancy and repeated pesticide residue analyses of children's urine and blood 27.…”

Section: Discussionmentioning

confidence: 99%

Assessment of long-term and recent pesticide exposure among rural school children in Nicaragua

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Assessment of long-term and recent pesticide exposure among rural school children in Nicaragua

et al. 2011

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“…Pregnant women may be concerned about using DEET or the other suggested compounds. The available data on toxic effects in humans and animals are reassuring for DEET (306)(307)(308)(309)(310)(311)(312), with the exception of the results of one animal study that assessed much higher doses than the normal human dose (313) and a retrospective human study that noted an association between hypospadias and insect repellent use during the first trimester of pregnancy (314). Interpretation of the latter study should be done with caution, as the methodology used cannot establish a causal relationship.…”

Section: Women Of Childbearing Age and Pregnant Patients Traveling Tomentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

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“…Last, though we could not find detectable levels of the other pesticides, we cannot completely rule out their implication in the onset of the DKA since they are much more rapidly metabolised in humans 6. Unfortunately, the patient refused a fat biopsy, a tissue in which most lipophilic pesticides are long-lasting.…”

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confidence: 75%